Featured Research

from universities, journals, and other organizations

Bladder cancer patients identified who could benefit from 'tumor-softening' treatment

Date:
July 30, 2014
Source:
Cancer Research UK
Summary:
A protein that could help doctors decide whichbladder cancerpatients would benefit from a treatment that makes radiotherapy more effective has been identified by researchers. The HIF-1-alpha protein indicates low oxygen levels in tumor cells -- a state known as 'hypoxia'. The CON treatment works by adding oxygen to the oxygen-deprived tumor cells which makes them more sensitive to the radiotherapy.

Scientists in Manchester have identified a protein that could help doctors decide which bladder cancer patients would benefit from a treatment that makes radiotherapy more effective, according to a study published in the British Journal of Cancer (BJC).

Related Articles


"This fascinating new finding could help doctors adapt their treatments to patients with bladder cancer," said Nell Barrie, Cancer Research UK

The team from The University of Manchester, funded by the Medical Research Council, found that patients whose bladder tumor had high levels of a protein, called 'HIF-1α', were more likely to benefit from having carbogen -- oxygen mixed with carbon dioxide gas -- and nicotinamide tablets at the same time as their radiotherapy. The treatment, called 'CON', makes radiotherapy more effective.

By comparing levels of HIF-1α in tissue samples from 137 patients who had radiotherapy on its own or with CON, the researchers found the protein predicted which patients benefited from having CON. High levels of the protein were linked to better survival from the disease when patients had radiotherapy and CON. Patients with low protein levels did not benefit from having CON with their radiotherapy.

The HIF-1α protein indicates low oxygen levels in tumor cells -- a state known as 'hypoxia'. The CON treatment works by adding oxygen to the oxygen-deprived tumor cells which makes them more sensitive to the radiotherapy.

Study author, Professor Catharine West, a Cancer Research UK scientist at The University of Manchester, said: "Although we have another biomarker that can predict responsiveness to CON and radiotherapy in bladder cancer patients, our findings tell us a bit more about the characteristics of bladder cancer tumors and how they may respond to this treatment."

"But we desperately need to do more work to find ways to treat those patients who won't see as much benefit from this.

"And it's exactly this type of vital research that we and other scientists will be doing at the Manchester Cancer Research Centre -- bringing together a wide range of expertise to revolutionise cancer treatment."

Around 65 people are diagnosed with bladder cancer in Manchester every year. There are around 25 deaths from the disease every year.

Nell Barrie, senior science communications manager at Cancer Research UK, said: "This fascinating new finding could help doctors adapt their treatments to patients with bladder cancer as well as shedding more light on the disease.

"Deaths from bladder cancer are falling in the UK, but more work needs to be done so that this trend continues. More research is needed to helps us find new and better ways to fight bladder cancer."


Story Source:

The above story is based on materials provided by Cancer Research UK. Note: Materials may be edited for content and length.


Journal Reference:

  1. B A Hunter, A Eustace, J J Irlam, H R Valentine, H Denley, K K Oguejiofor, R Swindell, P J Hoskin, A Choudhury, C M West. Expression of hypoxia-inducible factor-1α predicts benefit from hypoxia modification in invasive bladder cancer. British Journal of Cancer, 2014; 111 (3): 437 DOI: 10.1038/bjc.2014.315

Cite This Page:

Cancer Research UK. "Bladder cancer patients identified who could benefit from 'tumor-softening' treatment." ScienceDaily. ScienceDaily, 30 July 2014. <www.sciencedaily.com/releases/2014/07/140730120154.htm>.
Cancer Research UK. (2014, July 30). Bladder cancer patients identified who could benefit from 'tumor-softening' treatment. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2014/07/140730120154.htm
Cancer Research UK. "Bladder cancer patients identified who could benefit from 'tumor-softening' treatment." ScienceDaily. www.sciencedaily.com/releases/2014/07/140730120154.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins