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Fertile discovery: Treating male infertility with synthetic protein

Date:
August 11, 2014
Source:
Queen's University
Summary:
A promising method of treating male infertility using a synthetic version of the sperm-originated protein known as PAWP has been developed by researchers. The research promises to diagnose and treat cases of male factor infertility where a patient's sperm is unable to initiate or induce activation of the egg to form an early embryo.

Queen's University researcher Richard Oko and his co-investigators have come up with a promising method of treating male infertility using a synthetic version of the sperm-originated protein known as PAWP.

They found this protein is sufficient and required to initiate the fertilization process.

Dr. Oko's research promises to diagnose and treat cases of male factor infertility where a patient's sperm is unable to initiate or induce activation of the egg to form an early embryo.

"PAWP is able to induce embryo development in human eggs in a fashion similar to the natural triggering of embryo development by the sperm cell during fertilization," explains Dr. Oko (Biomedical and Molecular Sciences). "Based on our findings, we envision that physicians will be able to improve their diagnosis and treatment of infertility, a problem that affects 10 to 15 per cent of couples worldwide."

The results of this study highlight the potential clinical applications of sperm PAWP as a predictor of infertility treatment. Since most human infertility treatments are now done by injecting a single sperm directly into an egg, supplementation of human sperm with PAWP protein may potentially be used to improve the success rate of infertility treatments in the future.

According to the Centers for Disease Control and Prevention's 2013 Annual Report on Assisted Reproductive Technologies, only about 37 per cent of treatment cycles lead to successful pregnancy. This low success rate may be due to a variety of factors in the male and female including the inability of sperm cell to initiate fertilization and trigger embryo development upon egg entry.

"The results of our study set the stage for further investigation of PAWP protein as a molecular marker for diagnosis and as a factor for improvement of infertility treatments," says Dr. Oko.


Story Source:

The above story is based on materials provided by Queen's University. The original article was written by Anne Craig. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. Aarabi, H. Balakier, S. Bashar, S. I. Moskovtsev, P. Sutovsky, C. L. Librach, R. Oko. Sperm-derived WW domain-binding protein, PAWP, elicits calcium oscillations and oocyte activation in humans and mice. The FASEB Journal, 2014; DOI: 10.1096/fj.14-256495

Cite This Page:

Queen's University. "Fertile discovery: Treating male infertility with synthetic protein." ScienceDaily. ScienceDaily, 11 August 2014. <www.sciencedaily.com/releases/2014/08/140811125116.htm>.
Queen's University. (2014, August 11). Fertile discovery: Treating male infertility with synthetic protein. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2014/08/140811125116.htm
Queen's University. "Fertile discovery: Treating male infertility with synthetic protein." ScienceDaily. www.sciencedaily.com/releases/2014/08/140811125116.htm (accessed September 18, 2014).

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