A research team based at the Massachusetts General Hospital (MGH) has discovered a new gene that appears to play a role in Alzheimer's disease. The gene produces a protein in nerve cells, and the researchers found excessive quantities of this protein in brain tissue and cerebrospinal fluid (CSF) of people with Alzheimer's. They also showed that accumulation in nerve cells of this protein, called AD7c-NTP, causes changes similar to those seen in Alzheimer's, including cell death. Published in the December issue of the Journal of Clinical Investigation, the study additionally describes a highly sensitive and specific assay for AD7c-NTP, developed by scientists from the Nymox Corporation.
The above story is based on materials provided by Massachusetts General Hospital. Note: Materials may be edited for content and length.
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