Featured Research

from universities, journals, and other organizations

Hybrid Antibody Created At National Jewish Medical And Research Center 'Turns Off' CD4 T Cells Responsible For Organ Transplant Rejection

Date:
February 26, 1998
Source:
National Jewish Medical And Research Center
Summary:
Organ transplant rejection caused by CD4 T cells could be stopped in the future using a new hybrid antibody developed at National Jewish Medical and Research Center.

DENVER--Organ transplant rejection caused by CD4 T cells could be stopped in the future using a new hybrid antibody developed at National Jewish Medical and Research Center.

In the March issue of Nature Biotechnology, National Jewish researcher Uwe Staerz, M.D., Ph.D., describes a promising new way to "turn off" the CD4 T cell's attack on a transplanted organ. In 1996, Dr. Staerz described how to control CD8 T cells, which also play a major role in organ transplant rejection.

Dr. Staerz estimates clinical trials with the hybrid antibody could take place in approximately two years.

The hybrid antibody developed by Dr. Staerz and Yan Qi, M.D., of National Jewish, selectively "turns off" only the CD4 T cells that attack a transplanted organ. The rest of the body's defenses would be unaffected by the hybrid antibody, allowing the immune system to combat other illnesses. "The T cell sees the transplanted cell, but can't be activated against it," Dr. Staerz explains. "Any other immune response, such as the body defending itself against infections, will go on at the same time without being affected."

Current anti-rejection drugs stop organ rejection and completely suppress the body's immune system, sometimes allowing development of pneumonia, cancer, or other diseases or illnesses.

"Everybody who gets an organ transplant gets sick to a certain extent," Dr. Staerz explains. "This treatment could help prevent that."

When available, this treatment could be necessary only for several weeks following a transplant. Current anti-rejection drugs must be taken for the transplant recipient's entire life to control organ rejection. The hybrid antibody activity may eventually destroy the T cells that normally attack the transplanted organ, preventing future organ rejection, Dr. Staerz says.

Because a biological "match" must be made between the donor organ and recipient, the odds of a successful organ match are 1 in 100,000. Using a hybrid antibody for treatment, the chance of a successful match may increase to 1 in 4. There were more than 19,000 organ transplants in the United States in 1996, according to the United Network for Organ Sharing.

T cells, known as the body's "killer cells," act as immune-system defenders. Recognized as a foreign object, a transplanted organ is attacked by T cells. In addition, in autoimmune diseases, such as multiple sclerosis, juvenile diabetes and rheumatoid arthritis, T cells attack the body's own cells. The hybrid antibody could be used to help people with these diseases, as well.

For information about National Jewish, call LUNG LINE, (800) 222-LUNG.


Story Source:

The above story is based on materials provided by National Jewish Medical And Research Center. Note: Materials may be edited for content and length.


Cite This Page:

National Jewish Medical And Research Center. "Hybrid Antibody Created At National Jewish Medical And Research Center 'Turns Off' CD4 T Cells Responsible For Organ Transplant Rejection." ScienceDaily. ScienceDaily, 26 February 1998. <www.sciencedaily.com/releases/1998/02/980226001848.htm>.
National Jewish Medical And Research Center. (1998, February 26). Hybrid Antibody Created At National Jewish Medical And Research Center 'Turns Off' CD4 T Cells Responsible For Organ Transplant Rejection. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/1998/02/980226001848.htm
National Jewish Medical And Research Center. "Hybrid Antibody Created At National Jewish Medical And Research Center 'Turns Off' CD4 T Cells Responsible For Organ Transplant Rejection." ScienceDaily. www.sciencedaily.com/releases/1998/02/980226001848.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Ebola Patient Told Hospital He Was from Liberia

Ebola Patient Told Hospital He Was from Liberia

AP (Oct. 1, 2014) The first Ebola patient diagnosed in the U.S. initially went to a Dallas emergency room last week but was sent home, despite telling a nurse that he had been in disease-ravaged West Africa, the hospital acknowledged Wednesday. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins