Featured Research

from universities, journals, and other organizations

Penn Researchers Create Drug To Help Target Attack On Cancerous Tumors

Date:
March 2, 1998
Source:
University Of Pennsylvania Medical Center
Summary:
Researchers at the University of Pennsylvania Cancer Center have developed a drug that will help doctors fine- tune cancer treatments to patients. The drug, EF5, permits doctors to effectively determine the oxygen content of a tumor-- which subsequently dictates the appropriate course of treatment to be followed.

Philadelphia, PA -- Researchers at the University of Pennsylvania Cancer Center have developed a drug that will help doctors fine- tune cancer treatments to patients. The drug, EF5, permits doctors to effectively determine the oxygen content of a tumor-- which subsequently dictates the appropriate course of treatment to be followed.

Related Articles


Cancer clinicians have long known that hypoxic tumors--which thrive in oxygen-starved environments--are much more resistant to radiation and chemotherapy than their non-hypoxic cousins. But until now, physicians have had difficulty assessing hypoxicity

"When we know which tumors are hypoxic, we'll be able to custom-tailor a patient's cancer treatment," says Gillies McKenna, MD, Chair of Radiation Oncology at the University of Pennsylvania Cancer Center. "This may mean prescribing a more aggressive form of therapy, such as modifying the way radiation is delivered, or giving radiation in combination with drugs designed to exploit the hypoxic nature of the tumor," says McKenna.

EF5, developed by Cameron J. Koch, PhD, Professor of Radiation Oncology, was recently approved by the FDA for a Phase I clinical trial at the University of Pennsylvania Medical Center.

Patients with early stage cervix tumors, located at the neck of the uterus, and soft tissue sarcomas, are given EF5 intravenously two days before their tumors are surgically removed or biopsied. During this time, EF5 attaches or "binds" to hypoxic tumor cells, but "washes out" of tumor regions that are oxygen-rich. A small portion of the tumor, removed at surgery, is then exposed to fluorescent monoclonal antibodies.* These antibodies fasten to the hypoxic regions in the tumor and highlight its oxygen content.

Sydney Evans, VMD, Assistant Professor of Veterinary Medicine, has spent the last several years demonstrating the safety and efficacy of EF5 in animal tumor models and says that EF5 has shown no toxicity in animal studies.

In the trial, a second method of measuring hypoxia is also employed where a thin needle electrode is inserted into the tumor to measure the oxygen content. The needle electrode measures the amount of oxygen along the track of the needle. "Using the needle electrode is currently considered the standard method for measuring the tumor's oxygen content. However, by using EF5 with the needle electrode, we will have more precise information as to the amount and location of the oxygen within the entire tumor. Hopefully, it will increase the accuracy of tumor hypoxia diagnosis," Koch explains.

In the future, Penn researchers hope to adapt the EF5 technique for use with the Positron Emission Tomography (PET) imaging, which will allow for a non-invasive procedure of identifying the oxygen content within the patient's tumor. "Applications of this drug are far-reaching," says Evans. "We'll be able to non-invasively examine the binding of EF5 for other diseases in which hypoxia occurs, such as heart attacks and strokes, in addition to the use in cancer."

###*The fluorescent monoclonal antibodies were developed by Dr. Edith M. Lord, of the University of Rochester Cancer Center.


Story Source:

The above story is based on materials provided by University Of Pennsylvania Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Pennsylvania Medical Center. "Penn Researchers Create Drug To Help Target Attack On Cancerous Tumors." ScienceDaily. ScienceDaily, 2 March 1998. <www.sciencedaily.com/releases/1998/03/980302070943.htm>.
University Of Pennsylvania Medical Center. (1998, March 2). Penn Researchers Create Drug To Help Target Attack On Cancerous Tumors. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/1998/03/980302070943.htm
University Of Pennsylvania Medical Center. "Penn Researchers Create Drug To Help Target Attack On Cancerous Tumors." ScienceDaily. www.sciencedaily.com/releases/1998/03/980302070943.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
Dads-To-Be Also Experience Hormone Changes During Pregnancy

Dads-To-Be Also Experience Hormone Changes During Pregnancy

Newsy (Dec. 18, 2014) A study from University of Michigan researchers found that expectant fathers see a decrease in testosterone as the baby's birth draws near. Video provided by Newsy
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins