Featured Research

from universities, journals, and other organizations

University Of Iowa Researchers Propose A Model To Explain The Spread Of An Eye Cancer

Date:
April 9, 1998
Source:
University Of Iowa
Summary:
Cancer that develops in one part of the body often spreads to another site in a process called metastasis. Scientists have not worked out the details to explain how cancer spreads throughout the body or why some forms of the disease distribute to specific organs. However, research conducted at the University of Iowa College of Medicine sheds new light on the mysteries of metastasis.

IOWA CITY, Iowa -- Cancer that develops in one part of the body often spreads to another site in a process called metastasis.

Scientists have not worked out the details to explain how cancer spreads throughout the body or why some forms of the disease distribute to specific organs. However, research conducted at the University of Iowa College of Medicine sheds new light on the mysteries of metastasis.

The work was a collaborative effort between Dr. Mary J.C. Hendrix, professor and head of anatomy and cell biology, and associate director for basic research at the UI Cancer Center, Dr. Robert Folberg, F.C. Blodi Professor of Ophthalmology and Visual Sciences, and professor of pathology, their colleagues in those departments, and the UI Cancer Center.

The investigators studied a cancer of the eye known as uveal melanoma -- a potentially blinding and fatal form of cancer that tends to spread to the liver. Currently, the most common forms of treatment for the cancer are radiation therapy, which may cause blindness or removal of the eye. The UI research may lead to new forms of vision-sparing treatments that prolong the life of the patients. The findings, published in the current issue of the American Journal of Pathology and illustrated on the journal's cover, may also help scientists better understand the metastatic process.

There are proteins located inside normal cells that help maintain the cell's shape. In some forms of cancer, however, abnormal shape-maintaining proteins appear, thus increasing the likelihood that the cancer will spread. This is true for other forms of cancer, not just uveal melanoma.

The researchers found that malignant eye cells containing the abnormal proteins respond to a substance called hepatocyte growth factor/scatter factor, also known as HGF/SF. HGF/SF attracts blood vessels into the tumor and causes the cancer cells to divide, change shape and spread. The liver is a major site of HGF/SF production, and uveal melanoma tends to spread to that organ selectively.

Hendrix believes that this research can help explain how cancer cells begin to invade and distribute throughout the body.

"We hope that this experimental work will provide us and others with data to design new and more effective forms of cancer treatment," Hendrix said.

This work was supported by grants from the National Cancer Institute, the National Eye Institute, the University of Iowa Endowment, and Research to Prevent Blindness, Inc.


Story Source:

The above story is based on materials provided by University Of Iowa. Note: Materials may be edited for content and length.


Cite This Page:

University Of Iowa. "University Of Iowa Researchers Propose A Model To Explain The Spread Of An Eye Cancer." ScienceDaily. ScienceDaily, 9 April 1998. <www.sciencedaily.com/releases/1998/04/980409081130.htm>.
University Of Iowa. (1998, April 9). University Of Iowa Researchers Propose A Model To Explain The Spread Of An Eye Cancer. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/1998/04/980409081130.htm
University Of Iowa. "University Of Iowa Researchers Propose A Model To Explain The Spread Of An Eye Cancer." ScienceDaily. www.sciencedaily.com/releases/1998/04/980409081130.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins