Featured Research

from universities, journals, and other organizations

Transgenic Potato Confers Immunity: Vegetables Or Fruit Could Replace Vaccine And Needles

Date:
April 28, 1998
Source:
University Of Maryland, Baltimore
Summary:
Transgenic potatoes engineered to generate an immune response to E.coli infection have passed their first test in human beings, in a proof-of-principle clinical trial at the University of Maryland School of Medicine Center for Vaccine Development.

Transgenic potatoes engineered to generate an immune response to E.coli infection have passed their first test in human beings.

In the May issue of the journal Nature Medicine, Carol Tacket, MD, professor at the University of Maryland School of Medicine, and colleagues report successful results of their first human clinical trial of the transgenic vegetables developed at the Boyce Thompson Institute for Plant Research, affiliated with Cornell University in Ithaca, NY. Fed to healthy human volunteers at the University of Maryland Center for Vaccine Development, potatoes genetically engineered to contain a gene from the E.coli bacteria produced antibodies in the blood and in the mucosal lining of the intestines. Volunteers who ate garden-variety potatoes in the randomized, double-blind trial showed no immune response.

"It is truly remarkable to think that you could eat a potato that has an extra protein and produce antibodies against a bacterial pathogen," Tacket remarks, "but that is exactly what happened." She calls transgenic plants "a new strategy for development of safe and inexpensive vaccines against diseases such as tetanus, diphtheria and hepatitis B. Oral vaccines in edible plants offer hope of a more practical means of implementing universal vaccination programs for the developing world."

The volunteers consumed three doses of 100 or 50 grams of raw, peeled, cubed potato over 21 days. Blood and stool samples were collected before the first dose, after one, two, three and four weeks, and after 59 days.

Volunteers kept journals, recording any symptoms for three days after each dose. The potatoes were generally well tolerated, the researchers report. The study was conducted as a proof of principle. Tacket’s collaborators had already tested the transgenic potatoes and generated a strong immune response in mice. "We knew that we had an immunogenic protein in a plant that is eaten by human beings," she explains. "We wanted to determine if human beings would develop a serum and/or mucosal response to an antigen delivered in an uncooked food."

Tacket says the next step will be to try an antigen that does not generate an immune response as readily, possibly one from hepatitis. Studies also are needed to determine how long immunity lasts and to develop other transgenic plants that could carry safe and inexpensive vaccines to the populations of countries where they are grown and are part of the normal diet.

The research was supported by the National Institute of Allergy and Infectious Diseases’ Division of Microbiology and Infectious Diseases, National Institutes of Health.


Story Source:

The above story is based on materials provided by University Of Maryland, Baltimore. Note: Materials may be edited for content and length.


Cite This Page:

University Of Maryland, Baltimore. "Transgenic Potato Confers Immunity: Vegetables Or Fruit Could Replace Vaccine And Needles." ScienceDaily. ScienceDaily, 28 April 1998. <www.sciencedaily.com/releases/1998/04/980428080000.htm>.
University Of Maryland, Baltimore. (1998, April 28). Transgenic Potato Confers Immunity: Vegetables Or Fruit Could Replace Vaccine And Needles. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/1998/04/980428080000.htm
University Of Maryland, Baltimore. "Transgenic Potato Confers Immunity: Vegetables Or Fruit Could Replace Vaccine And Needles." ScienceDaily. www.sciencedaily.com/releases/1998/04/980428080000.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins