Featured Research

from universities, journals, and other organizations

Anti-Angiogenesis: A New Weapon In Cancer Therapy

Date:
May 6, 1998
Source:
Noonan/russo Communications
Summary:
As reported this week, Dr. Judah Folkman's promising work in cutting off a tumor's blood supply to treat cancer in mice has excited The National Cancer Institute as well as scientists throughout the industry. A novel concept that Folkman began researching 30 years ago, the inhibition of blood supply to tumors seems critical to the removal of tumors and the prevention of metastases.

As reported this week, Dr. Judah Folkman's promising work in cutting off a tumor's blood supply to treat cancer in mice has excited The National Cancer Institute as well as scientists throughout the industry. A novel concept that Folkman began researching 30 years ago, the inhibition of blood supply to tumors seems critical to the removal of tumors and the prevention of metastases.

To date, Folkman's angiostatin and endostatin proteins have completely eradicated tumors while avoiding side effects in mice. This research suggests that mechanisms that inhibit angiogenesis will have potential as cancer therapeutics.

If you are working on a story regarding the breakthrough of anti-angiogenesis for cancer therapy, you might be interested in related work being done by Ribozyme Pharmaceuticals, Inc. (RPI). Through the use of ribozymes, short RNA molecules that are designed to cleave specific RNA sequences and thereby inhibit the synthesis of disease-causing proteins, RPI is using an anti-VEGF receptor ribozyme to inhibit angiogenesis and thus restrain tumor growth. Preclinical studies have indicated efficacy of the ribozyme as an anti-angiogenic agent in multiple animal models in various cancers and in the eye. Most recently, the anti-VEGF receptor ribozyme has demonstrated the ability to inhibit the development of tumor blood vessels in mice bearing Lewis Lung Carcinoma, resulting in the inhibition of both tumor growth and metastasis.

Note to journalists: If you would like to speak with Dr. Ralph Christoffersen of RPI or would like additional information on RPI's anti-angiogenesis program, please call Neil Cohen, ext. 205 or Lara Kaplan, ext, 246, both of Noonan/Russo Communications, 212-696-4455.


Story Source:

The above story is based on materials provided by Noonan/russo Communications. Note: Materials may be edited for content and length.


Cite This Page:

Noonan/russo Communications. "Anti-Angiogenesis: A New Weapon In Cancer Therapy." ScienceDaily. ScienceDaily, 6 May 1998. <www.sciencedaily.com/releases/1998/05/980506075420.htm>.
Noonan/russo Communications. (1998, May 6). Anti-Angiogenesis: A New Weapon In Cancer Therapy. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/1998/05/980506075420.htm
Noonan/russo Communications. "Anti-Angiogenesis: A New Weapon In Cancer Therapy." ScienceDaily. www.sciencedaily.com/releases/1998/05/980506075420.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins