Featured Research

from universities, journals, and other organizations

System Combines Capillary Electrophoresis And NMR Spectroscopy

Date:
July 10, 1998
Source:
University Of Illinois At Urbana-Champaign
Summary:
By using micro-electromechanical systems (MEMS) technology, researchers at the University of Illinois have developed a chip-based analytical system that combines capillary electrophoresis and nuclear magnetic resonance (NMR) spectroscopy.

CHAMPAIGN, Ill. -- By using micro-electromechanical systems (MEMS) technology, researchers at the University of Illinois have developed a chip-based analytical system that combines capillary electrophoresis and nuclear magnetic resonance (NMR) spectroscopy. Integrated microfluidic-NMR systems could have important applications in a wide variety of combinatorial chemistry areas -- such as drug discovery -- and might facilitate the development of desktop NMR spectrometers.

"Capillary electrophoresis and NMR spectroscopy have competing design goals, but by integrating them with MEMS technology we can maximize the performance of both systems," said David Beebe, a professor of electrical and computer engineering and a researcher at the university's Beckman Institute for Advanced Science and Technology. "By using very small channels and samples, we can do high-performance capillary electrophoresis separations. And by performing those separations multiple times, we can collect a large enough sample to do NMR spectroscopy."

Beebe and U. of I. colleagues Richard Magin, Jonathan Trumbull and Ian Glasgow fabricated and tested two microfluidic-NMR devices. In the first device, designed as a proof of concept, the microfluidic channels were built from layered polyimide. In the second device, the channels -- or capillaries -- were etched into glass wafers. In both devices, the single-turn, planar NMR coils were formed from evaporated layers of chromium and copper.

"Although planar coils are less sensitive than solenoidal coils, they are easily integrated into batch-fabricated analytical devices," Beebe said. "The use of MEMS fabrication techniques allows precise control over the geometric parameters and materials that are so important to the performance of NMR microcoil detection. This allows one to more easily optimize the performance."

In order to optimize the weak signal received from small sample volumes, it is very important that the NMR coil does not disrupt the uniformity of the static magnetic field. By tuning the thickness of the evaporated metal layers, Beebe and his colleagues can make the coil transparent to the magnetic field, thus preventing any perturbations in the field.

"By shrinking the sample size to the nanoliter range, the volume over which the magnetic field must be uniform is also significantly reduced," Beebe said. "This should allow either a smaller -- and less expensive magnet -- to be used, or multiple spectrums to be taken in parallel in a conventional magnet, thereby multiplying throughput. With the large initial expenditure for a high-field superconducting magnet and the associated cost of ownership, these benefits are significant with small samples."

The researchers described their microfluidic-NMR system and presented preliminary results at the Solid-State Sensor and Actuator Workshop, held June 7-11 at Hilton Head Island, S.C.


Story Source:

The above story is based on materials provided by University Of Illinois At Urbana-Champaign. Note: Materials may be edited for content and length.


Cite This Page:

University Of Illinois At Urbana-Champaign. "System Combines Capillary Electrophoresis And NMR Spectroscopy." ScienceDaily. ScienceDaily, 10 July 1998. <www.sciencedaily.com/releases/1998/07/980710080840.htm>.
University Of Illinois At Urbana-Champaign. (1998, July 10). System Combines Capillary Electrophoresis And NMR Spectroscopy. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/1998/07/980710080840.htm
University Of Illinois At Urbana-Champaign. "System Combines Capillary Electrophoresis And NMR Spectroscopy." ScienceDaily. www.sciencedaily.com/releases/1998/07/980710080840.htm (accessed October 2, 2014).

Share This



More Matter & Energy News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Japan Looks To Faster Future As Bullet Train Turns 50

Japan Looks To Faster Future As Bullet Train Turns 50

Newsy (Oct. 1, 2014) Japan's bullet train turns 50 Wednesday. Here's a look at how it's changed over half a century — and the changes it's inspired globally. Video provided by Newsy
Powered by NewsLook.com
US Police Put Body Cameras to the Test

US Police Put Body Cameras to the Test

AFP (Oct. 1, 2014) Police body cameras are gradually being rolled out across the US, with interest surging after the fatal police shooting in August of an unarmed black teenager. Duration: 02:18 Video provided by AFP
Powered by NewsLook.com
Raw: Japan Celebrates 'bullet Train' Anniversary

Raw: Japan Celebrates 'bullet Train' Anniversary

AP (Oct. 1, 2014) A ceremony marking 50 years since Japan launched its Shinkansen bullet train was held on Wednesday in Tokyo. The latest model can travel from Tokyo to Osaka, a distance of 319 miles, in two hours and 25 minutes. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins