Featured Research

from universities, journals, and other organizations

University Of Kentucky Neuroscientist Develops Unique Device For Treatment Of Brain Tumors

Date:
August 14, 1998
Source:
University Of Kentucky Medical Center
Summary:
A device patented by a University of Kentucky Chandler Medical Center neuroscientist has shown promising early results in patient survival times in treatment of malignant gliomas, the most common type of brain tumor in adults.

LEXINGTON, Ky., Aug. 3, 1998 -- A device patented by a University of Kentucky Chandler Medical Center neuroscientist has shown promising early results in patient survival times in treatment of malignant gliomas, the most common type of brain tumor in adults.

The device, called Serodur, delivers chemotherapy to a non-operable brain tumor through a small plastic tube that runs directly into the center of the tumor. The tube is connected to a small plastic bubble, called an Ommaya reservoir, that is implanted under the patient's scalp. A cellophane-like permeable membrane in the bubble regulates the flow of the cancer-fighting drug into the tumor.

"By using Serodur, we're able to give small total doses that produce large concentrations of anticancer drugs in the brain without exposing the patient's body to the systemic effects of the medicine," said Roy Patchell, M.D., University of Kentucky Chandler Medical Center neuroscientist and inventor of the device. "Our studies are preliminary, but we've seen some long-term survivors, which is unusual for this kind of cancer."

More than half of the patients who contract a malignant glioma live less than one year, despite aggressive treatment with surgery, radiation therapy and intravenous chemotherapy, Patchell said. Intravenous chemotherapy often causes severe toxicity, so patients cannot be given enough of the drug to have effective results. In addition, many anticancer drugs cannot cross the blood-brain barrier in concentrations high enough to kill the tumor. When drugs do get into the brain, they only remain active for a few hours -- not enough time to destroy the tumor.

By running the tube directly into patients' tumors, Patchell has been able to eliminate side effects normally associated with chemotherapy, such as nausea, hair loss and fatigue. The survival rates of patients who have tried Serodur is even more impressive.

"Most patients with recurrent gliomas live two or three months," Patchell said. "We've had some patients live three years."

Two drugs currently are being studied for their effectiveness against the cancer. One drug, Bleomycin, is administered to patients with newly diagnosed malignant gliomas that have been treated with surgery and radiation, but not chemotherapy. The second study is an early phase trial of the drug Adriamycin in the treatment of recurrent high grade gliomas. Patients in this trial already have had radiation therapy, and may have received other treatments, including chemotherapy.

The early results are promising, but Patchell stressed that the studies are preliminary.

"The next step is to try Serodur on a large sample of patients to validate our preliminary results," Patchell said. "I can't really say it's an effective treatment yet, but we have shown that we can shrink a patient's tumor and give them prolonged, quality life."


Story Source:

The above story is based on materials provided by University Of Kentucky Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Kentucky Medical Center. "University Of Kentucky Neuroscientist Develops Unique Device For Treatment Of Brain Tumors." ScienceDaily. ScienceDaily, 14 August 1998. <www.sciencedaily.com/releases/1998/08/980814063930.htm>.
University Of Kentucky Medical Center. (1998, August 14). University Of Kentucky Neuroscientist Develops Unique Device For Treatment Of Brain Tumors. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/1998/08/980814063930.htm
University Of Kentucky Medical Center. "University Of Kentucky Neuroscientist Develops Unique Device For Treatment Of Brain Tumors." ScienceDaily. www.sciencedaily.com/releases/1998/08/980814063930.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins