Featured Research

from universities, journals, and other organizations

Diabetes Drug And Accutane Block Breast Cancer Cell Growth, Cedars-Sinai Researchers Find

Date:
August 14, 1998
Source:
Cedars-Sinai Medical Center
Summary:
Breast cancer cells exposed to a diabetes drug and the Vitamin A compound Accutane stopped multiplying and died on cue in laboratory and animal studies conducted at Cedars-Sinai Medical Center, researchers reported in the journal Proceedings of the National Academy of Science.

LOS ANGELES (July 21, 1998) -- Breast cancer cells exposed to a diabetes drug and the Vitamin A compound Accutane stopped multiplying and died on cue in laboratory and animal studies conducted at Cedars-Sinai Medical Center, researchers reported today in the journal Proceedings of the National Academy of Science.

Related Articles


Troglitazone, an antidiabetes drug, and Accutane, a Vitamin A compound used to treat severe acne, appear to work synergistically in permanently inhibiting cell growth and inducing apoptosis (programmed cell death) in breast cancer cells.

"Troglitazone alone has a mild effect on breast cancer cells. Accutane alone has a mild effect on breast cancer cells. Together, they have a dramatic effect," said Dr. H. Phillip Koeffler, Director of Hematology/Oncology at Cedars-Sinai Medical Center and Professor of Medicine at the University of California, Los Angeles.

Breast cancer cells stay young and vigorous, proliferating wildly while normal cells around them perform their functions, then mature and die as other cells replace them, Dr. Koeffler explained. The highly selective approach he and his team used not only deprives breast cancer cells of the protein energy source that makes them grow, but also programs them to age and die on schedule.

Importantly, the drug combination appears to have no adverse effect on healthy cells, either in laboratory studies or in immunodeficient mice injected with human breast cells that form tumors.

The way in which the drugs work is not fully understood, although their success is probably due to their targeting of distinct receptors on breast cancer cells that give them an edge over other cells, Dr. Koeffler said.

Troglitazone binds two receptors found in tumor cells: a steroid receptor called peroxisome proliferator-activated receptor gamma (PPARg), and a retinoid (Vitamin A) receptor. Accutane may then bind to this combined receptor. The activated receptor complex causes a protected gene within the cancer cell to be modulated.

That gene, bcl-2, is associated with programmed cell death. At high levels, it prevents cell death. At low levels, it induces cell death. "When exposed to the two-drug combination, cancer cells express almost undetectable levels of bcl-2," Dr. Koeffler said.

Since results of the in vitro (laboratory) and animal experiments were successful, preliminary research has begun to determine whether the drug combination is successful in humans. The first patient with prostate cancer has been enrolled in a study of troglitazone, and a small trial involving women with metastatic breast cancer will soon be underway.

New cancer drugs are often first tested on patients with advanced disease, explained Dr. Koeffler, since proved therapies exist for those with more treatable, early-stage cancer. If the results are promising in the most-difficult-to-treat patients, research begins on patients with less advanced disease, he said.


Story Source:

The above story is based on materials provided by Cedars-Sinai Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Cedars-Sinai Medical Center. "Diabetes Drug And Accutane Block Breast Cancer Cell Growth, Cedars-Sinai Researchers Find." ScienceDaily. ScienceDaily, 14 August 1998. <www.sciencedaily.com/releases/1998/08/980814064207.htm>.
Cedars-Sinai Medical Center. (1998, August 14). Diabetes Drug And Accutane Block Breast Cancer Cell Growth, Cedars-Sinai Researchers Find. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/1998/08/980814064207.htm
Cedars-Sinai Medical Center. "Diabetes Drug And Accutane Block Breast Cancer Cell Growth, Cedars-Sinai Researchers Find." ScienceDaily. www.sciencedaily.com/releases/1998/08/980814064207.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins