Featured Research

from universities, journals, and other organizations

Blood-Flow Study Helps UT Southwestern Researchers Shed New Light On Childhood Muscular Dystrophy

Date:
December 14, 1998
Source:
University Of Texas Southwestern Medical Center At Dallas
Summary:
Researchers at UT Southwestern Medical Center at Dallas have made a critical discovery about blood-flow regulation during exercise and, in the process, have uncovered a clue about a culprit behind Duchenne dystrophy, also known as childhood muscular dystrophy.

DALLAS - December 7, 1998 - Researchers at UT Southwestern Medical Center at Dallas have made a critical discovery about blood-flow regulation during exercise and, in the process, have uncovered a clue about a culprit behind Duchenne dystrophy, also known as childhood muscular dystrophy.

Related Articles


In a study published in the Dec. 8 issue of Proceedings of the National Academy of Sciences, UT Southwestern researchers detail findings indicating that nitric oxide, one of the substances responsible for increasing blood flow to skeletal muscle during exercise, may derive from a different type of cell than previously thought.

Scientists have believed that the source of nitric oxide was a protein called endothelial nitric oxide synthase, a substance abundant in cells lining blood-vessel walls. But a UT Southwestern team led by Dr. Ronald G. Victor, chief of hypertension, and Dr. Gail Thomas, hypertension researcher, has found another form of the protein, which is widespread in skeletal-muscle fibers, appears to play a major role in the regulation of blood flow to contracting muscles.

Using genetically altered mice with a disease resembling human muscular dystrophy, the team, for the first time, isolated a primary function of nitric oxide in skeletal muscle and pinpointed consequences of a reduction in the protein. In the mice whose levels of skeletal muscle nitric oxide synthase were greatly reduced, the ability to counter normal blood-vessel constriction during muscle contraction was seriously impaired. This impairment may help explain the primary symptom of Duchenne dystrophy, a progressive weakness that occurs as the disease spreads through muscle.

"We're excited about the implications of this latest study and are optimistic that this might help pave the way for further research on possible treatments for muscular dystrophy - a terrible disease that still has no cure," said Thomas, an instructor in internal medicine. "It's always exciting when you can solve even a small piece of the puzzle, and we hope that this latest finding will shed light on specific mechanisms contributing to the disease."

Other investigators involved in the project include UT Southwestern researchers Dr. Mikael Sander, hypertension fellow; Dr. Kim Lau, assistant professor of physiology; Dr. James T. Stull, professor and chairman of physiology; and Dr. Paul L. Huang of Massachusetts General Hospital and Harvard Medical School.

The American Heart Association's Texas affiliate, the National Institutes of Health, the Muscular Dystrophy Association, the Michaelson Foundation and the Danish Heart Foundation funded the research.


Story Source:

The above story is based on materials provided by University Of Texas Southwestern Medical Center At Dallas. Note: Materials may be edited for content and length.


Cite This Page:

University Of Texas Southwestern Medical Center At Dallas. "Blood-Flow Study Helps UT Southwestern Researchers Shed New Light On Childhood Muscular Dystrophy." ScienceDaily. ScienceDaily, 14 December 1998. <www.sciencedaily.com/releases/1998/12/981214075114.htm>.
University Of Texas Southwestern Medical Center At Dallas. (1998, December 14). Blood-Flow Study Helps UT Southwestern Researchers Shed New Light On Childhood Muscular Dystrophy. ScienceDaily. Retrieved November 1, 2014 from www.sciencedaily.com/releases/1998/12/981214075114.htm
University Of Texas Southwestern Medical Center At Dallas. "Blood-Flow Study Helps UT Southwestern Researchers Shed New Light On Childhood Muscular Dystrophy." ScienceDaily. www.sciencedaily.com/releases/1998/12/981214075114.htm (accessed November 1, 2014).

Share This



More Health & Medicine News

Saturday, November 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Melafind: Spotting Melanoma Without a Biopsy

Melafind: Spotting Melanoma Without a Biopsy

Ivanhoe (Oct. 31, 2014) The MelaFind device is a pain-free way to check suspicious moles for melanoma, without the need for a biopsy. Video provided by Ivanhoe
Powered by NewsLook.com
Battling Multiple Myeloma

Battling Multiple Myeloma

Ivanhoe (Oct. 31, 2014) The answer isn’t always found in new drugs – repurposing an ‘old’ drug that could mean better multiple myeloma treatment, and hope. Video provided by Ivanhoe
Powered by NewsLook.com
Chronic Inflammation and Prostate Cancer

Chronic Inflammation and Prostate Cancer

Ivanhoe (Oct. 31, 2014) New information that is linking chronic inflammation in the prostate and prostate cancer, which may help doctors and patients prevent cancer in the future. Video provided by Ivanhoe
Powered by NewsLook.com
Sickle Cell: Stopping Kids’ Silent Strokes

Sickle Cell: Stopping Kids’ Silent Strokes

Ivanhoe (Oct. 31, 2014) Blood transfusions are proving crucial to young sickle cell patients by helping prevent strokes, even when there is no outward sign of brain injury. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins