Featured Research

from universities, journals, and other organizations

Discovery May Boost Effectiveness Of Chemotherapy

Date:
December 22, 1998
Source:
University Of Maryland Medical Center
Summary:
Researchers at the University of Maryland Greenebaum Cancer Center have made a discovery that may explain why some cases of breast cancer and other forms of cancer are resistant to chemotherapy. Their findings, published in the December 22, 1998, issue of Proceedings of the National Academy of Sciences, may lead to better ways to target chemotherapy to individual patients and may open the door to new strategies to reverse resistance to cancer-fighting drugs.

Researchers at the University of Maryland Greenebaum Cancer Center have made a discovery that may explain why some cases of breast cancer and other forms of cancer are resistant to chemotherapy. Their findings, published in the December 22, 1998, issue of Proceedings of the National Academy of Sciences, may lead to better ways to target chemotherapy to individual patients and may open the door to new strategies to reverse resistance to cancer-fighting drugs.

"We have found a cancer resistance protein that rapidly pumps out chemotherapy from a certain line of breast cancer cells," says L. Austin Doyle, M.D., associate professor of medicine at the University of Maryland School of Medicine who is the lead author of the article.

The researchers call the newly-discovered pump Breast Cancer Resistance Protein (BCRP). They found that this protein pumped three common anti-cancer drugs out of cells rapidly, before the drugs could get to the nucleus of the cancer cells and destroy them.

"This is only the fourth molecular drug resistance pump of anti-cancer drugs to be identified, and it is half the size of the other pumps," says Douglas D. Ross, M.D., Ph.D, professor of medicine at the University of Maryland School of Medicine. "We had been looking for years for a way to explain resistance among this group of resistant cancer cells, so this is an important step," adds Dr. Ross, who is a co-author of the article.

The researchers, along with Lynne Abrusso, M.D., Ph.D, assistant professor of pathology at the University of Maryland School of Medicine, studied resistant and non-resistant cancer cells to find genes that were different among the two groups. They used molecular biology techniques to isolate the unique BCRP gene from drug-resistant cancer cells. Then, they tested their theory by changing non-resistant cells into resistant ones by inserting the BCRP gene into them.

"Drug resistance is a big problem for many patients with cancer," says Dr. Doyle. "We are trying to determine which cancers have this type of resistance. In the future, we may be able to help our patients by adding compounds to their chemotherapy that will block the protein products of genes that cause resistance."

One of the drugs these resistant cancer cells are able to pump away is mitoxantrone, a common first-line chemotherapy which is less toxic than many other anti-cancer drugs. It is often prescribed for breast cancer, leukemia, colon cancer and myeloma. "With these findings, we may be able to make this good drug even better," says Dr. Ross.

Mitoxantrone-resistant cell lines from breast, stomach and colon cancers as well as multiple myeloma all were found to have increased levels of the new cancer resistance protein.

The researchers are working on ways to overcome this newly-discovered form of resistance and improve the effectiveness of chemotherapy. Recently, they have tested a new compound that turns off the newly-discovered resistance protein and restores the ability of mitoxantrone and other chemotherapy drugs to kill cancer cells successfully.

Researchers at the University of Maryland Greenebaum Cancer Center are involved in a wide variety of basic and clinical research. The center provides a complete range of specialized services for all aspects of cancer care, and patients have access to promising new therapies before they are widely available.


Story Source:

The above story is based on materials provided by University Of Maryland Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Maryland Medical Center. "Discovery May Boost Effectiveness Of Chemotherapy." ScienceDaily. ScienceDaily, 22 December 1998. <www.sciencedaily.com/releases/1998/12/981222081321.htm>.
University Of Maryland Medical Center. (1998, December 22). Discovery May Boost Effectiveness Of Chemotherapy. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/1998/12/981222081321.htm
University Of Maryland Medical Center. "Discovery May Boost Effectiveness Of Chemotherapy." ScienceDaily. www.sciencedaily.com/releases/1998/12/981222081321.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins