Featured Research

from universities, journals, and other organizations

Discovery May Boost Effectiveness Of Chemotherapy

Date:
December 22, 1998
Source:
University Of Maryland Medical Center
Summary:
Researchers at the University of Maryland Greenebaum Cancer Center have made a discovery that may explain why some cases of breast cancer and other forms of cancer are resistant to chemotherapy. Their findings, published in the December 22, 1998, issue of Proceedings of the National Academy of Sciences, may lead to better ways to target chemotherapy to individual patients and may open the door to new strategies to reverse resistance to cancer-fighting drugs.

Researchers at the University of Maryland Greenebaum Cancer Center have made a discovery that may explain why some cases of breast cancer and other forms of cancer are resistant to chemotherapy. Their findings, published in the December 22, 1998, issue of Proceedings of the National Academy of Sciences, may lead to better ways to target chemotherapy to individual patients and may open the door to new strategies to reverse resistance to cancer-fighting drugs.

"We have found a cancer resistance protein that rapidly pumps out chemotherapy from a certain line of breast cancer cells," says L. Austin Doyle, M.D., associate professor of medicine at the University of Maryland School of Medicine who is the lead author of the article.

The researchers call the newly-discovered pump Breast Cancer Resistance Protein (BCRP). They found that this protein pumped three common anti-cancer drugs out of cells rapidly, before the drugs could get to the nucleus of the cancer cells and destroy them.

"This is only the fourth molecular drug resistance pump of anti-cancer drugs to be identified, and it is half the size of the other pumps," says Douglas D. Ross, M.D., Ph.D, professor of medicine at the University of Maryland School of Medicine. "We had been looking for years for a way to explain resistance among this group of resistant cancer cells, so this is an important step," adds Dr. Ross, who is a co-author of the article.

The researchers, along with Lynne Abrusso, M.D., Ph.D, assistant professor of pathology at the University of Maryland School of Medicine, studied resistant and non-resistant cancer cells to find genes that were different among the two groups. They used molecular biology techniques to isolate the unique BCRP gene from drug-resistant cancer cells. Then, they tested their theory by changing non-resistant cells into resistant ones by inserting the BCRP gene into them.

"Drug resistance is a big problem for many patients with cancer," says Dr. Doyle. "We are trying to determine which cancers have this type of resistance. In the future, we may be able to help our patients by adding compounds to their chemotherapy that will block the protein products of genes that cause resistance."

One of the drugs these resistant cancer cells are able to pump away is mitoxantrone, a common first-line chemotherapy which is less toxic than many other anti-cancer drugs. It is often prescribed for breast cancer, leukemia, colon cancer and myeloma. "With these findings, we may be able to make this good drug even better," says Dr. Ross.

Mitoxantrone-resistant cell lines from breast, stomach and colon cancers as well as multiple myeloma all were found to have increased levels of the new cancer resistance protein.

The researchers are working on ways to overcome this newly-discovered form of resistance and improve the effectiveness of chemotherapy. Recently, they have tested a new compound that turns off the newly-discovered resistance protein and restores the ability of mitoxantrone and other chemotherapy drugs to kill cancer cells successfully.

Researchers at the University of Maryland Greenebaum Cancer Center are involved in a wide variety of basic and clinical research. The center provides a complete range of specialized services for all aspects of cancer care, and patients have access to promising new therapies before they are widely available.


Story Source:

The above story is based on materials provided by University Of Maryland Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Maryland Medical Center. "Discovery May Boost Effectiveness Of Chemotherapy." ScienceDaily. ScienceDaily, 22 December 1998. <www.sciencedaily.com/releases/1998/12/981222081321.htm>.
University Of Maryland Medical Center. (1998, December 22). Discovery May Boost Effectiveness Of Chemotherapy. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/1998/12/981222081321.htm
University Of Maryland Medical Center. "Discovery May Boost Effectiveness Of Chemotherapy." ScienceDaily. www.sciencedaily.com/releases/1998/12/981222081321.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins