Featured Research

from universities, journals, and other organizations

Discovery May Boost Effectiveness Of Chemotherapy

Date:
December 22, 1998
Source:
University Of Maryland Medical Center
Summary:
Researchers at the University of Maryland Greenebaum Cancer Center have made a discovery that may explain why some cases of breast cancer and other forms of cancer are resistant to chemotherapy. Their findings, published in the December 22, 1998, issue of Proceedings of the National Academy of Sciences, may lead to better ways to target chemotherapy to individual patients and may open the door to new strategies to reverse resistance to cancer-fighting drugs.

Researchers at the University of Maryland Greenebaum Cancer Center have made a discovery that may explain why some cases of breast cancer and other forms of cancer are resistant to chemotherapy. Their findings, published in the December 22, 1998, issue of Proceedings of the National Academy of Sciences, may lead to better ways to target chemotherapy to individual patients and may open the door to new strategies to reverse resistance to cancer-fighting drugs.

"We have found a cancer resistance protein that rapidly pumps out chemotherapy from a certain line of breast cancer cells," says L. Austin Doyle, M.D., associate professor of medicine at the University of Maryland School of Medicine who is the lead author of the article.

The researchers call the newly-discovered pump Breast Cancer Resistance Protein (BCRP). They found that this protein pumped three common anti-cancer drugs out of cells rapidly, before the drugs could get to the nucleus of the cancer cells and destroy them.

"This is only the fourth molecular drug resistance pump of anti-cancer drugs to be identified, and it is half the size of the other pumps," says Douglas D. Ross, M.D., Ph.D, professor of medicine at the University of Maryland School of Medicine. "We had been looking for years for a way to explain resistance among this group of resistant cancer cells, so this is an important step," adds Dr. Ross, who is a co-author of the article.

The researchers, along with Lynne Abrusso, M.D., Ph.D, assistant professor of pathology at the University of Maryland School of Medicine, studied resistant and non-resistant cancer cells to find genes that were different among the two groups. They used molecular biology techniques to isolate the unique BCRP gene from drug-resistant cancer cells. Then, they tested their theory by changing non-resistant cells into resistant ones by inserting the BCRP gene into them.

"Drug resistance is a big problem for many patients with cancer," says Dr. Doyle. "We are trying to determine which cancers have this type of resistance. In the future, we may be able to help our patients by adding compounds to their chemotherapy that will block the protein products of genes that cause resistance."

One of the drugs these resistant cancer cells are able to pump away is mitoxantrone, a common first-line chemotherapy which is less toxic than many other anti-cancer drugs. It is often prescribed for breast cancer, leukemia, colon cancer and myeloma. "With these findings, we may be able to make this good drug even better," says Dr. Ross.

Mitoxantrone-resistant cell lines from breast, stomach and colon cancers as well as multiple myeloma all were found to have increased levels of the new cancer resistance protein.

The researchers are working on ways to overcome this newly-discovered form of resistance and improve the effectiveness of chemotherapy. Recently, they have tested a new compound that turns off the newly-discovered resistance protein and restores the ability of mitoxantrone and other chemotherapy drugs to kill cancer cells successfully.

Researchers at the University of Maryland Greenebaum Cancer Center are involved in a wide variety of basic and clinical research. The center provides a complete range of specialized services for all aspects of cancer care, and patients have access to promising new therapies before they are widely available.


Story Source:

The above story is based on materials provided by University Of Maryland Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Maryland Medical Center. "Discovery May Boost Effectiveness Of Chemotherapy." ScienceDaily. ScienceDaily, 22 December 1998. <www.sciencedaily.com/releases/1998/12/981222081321.htm>.
University Of Maryland Medical Center. (1998, December 22). Discovery May Boost Effectiveness Of Chemotherapy. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/1998/12/981222081321.htm
University Of Maryland Medical Center. "Discovery May Boost Effectiveness Of Chemotherapy." ScienceDaily. www.sciencedaily.com/releases/1998/12/981222081321.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins