Featured Research

from universities, journals, and other organizations

National Jewish Researchers Show Intravenous Immunoglobulin Reduces Steroid Insensitivity, Hospitalizations Of People With Severe Asthma

Date:
March 19, 1999
Source:
National Jewish Medical And Research Center
Summary:
People with severe asthma who are "insensitive" to steroids need less of the medication, fewer "bursts" of it in emergencies and spend less time in the hospital when using intravenous immunoglobulin (IVIG) in conjunction with steroids, according to research published today in the Journal of Allergy and Clinical Immunology.

DENVER-People with severe asthma who are "insensitive" to steroids need less of the medication, fewer "bursts" of it in emergencies and spend less time in the hospital when using intravenous immunoglobulin (IVIG) in conjunction with steroids, according to research published today in the Journal of Allergy and Clinical Immunology.

Researchers found that during the 6-month study, patients had fewer hospitalizations for asthma attacks than in the 6 months prior to the study, even though they used less glucocorticoids, known generally as steroids.

IVIG also was as effective in people whose asthma can be treated with glucocorticoids, as it was in people whose asthma usually doesn't respond to glucocorticoids, or who are "steroid-insensitive." Researchers believe IVIG increases steroid sensitivity of the lungs to steroids, in part, by reducing lung inflammation. "We saw patients whose asthma does very poorly and who needed high doses of steroids to control the disease," said Erwin Gelfand, M.D., a pediatric immunology and asthma specialist and chair of the Department of Pediatrics at National Jewish Medical and Research Center.

While steroid-insensitive patients must take higher doses to achieve minimal control of their disease, they also may become dependent on the medication to breathe normally. Researchers found that by taking IVIG in conjunction with glucocorticoids, patients could use less glucocorticoids more efficiently.

Long-term use of glucocorticoids can stunt growth in children or cause osteoporosis, while IVIG has few side effects. "Compared to steroids, IVIG is not toxic at all," Dr. Gelfand said. "In addition, lowering the amount of steroids a patient takes reduces side effects and the patient's quality of life improves dramatically."

IVIG treatments cost several thousand dollars each month for people with severe asthma, but many health insurance companies cover the cost because, as this study shows, IVIG lowers emergency room and hospital use by patients with severe asthma. Glucocorticoids reduce inflammation in the lungs. IVIG is an antibody that is removed from the plasma portion of blood and is concentrated for use as a medication. IVIG can regulate the immune/inflammatory system and has been shown to reduce inflammation in the lungs.

National Jewish Medical and Research Center is ranked as the best hospital in the United States for respiratory diseases by U.S. News & World Report, 1998-1999.


Story Source:

The above story is based on materials provided by National Jewish Medical And Research Center. Note: Materials may be edited for content and length.


Cite This Page:

National Jewish Medical And Research Center. "National Jewish Researchers Show Intravenous Immunoglobulin Reduces Steroid Insensitivity, Hospitalizations Of People With Severe Asthma." ScienceDaily. ScienceDaily, 19 March 1999. <www.sciencedaily.com/releases/1999/03/990316130947.htm>.
National Jewish Medical And Research Center. (1999, March 19). National Jewish Researchers Show Intravenous Immunoglobulin Reduces Steroid Insensitivity, Hospitalizations Of People With Severe Asthma. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/1999/03/990316130947.htm
National Jewish Medical And Research Center. "National Jewish Researchers Show Intravenous Immunoglobulin Reduces Steroid Insensitivity, Hospitalizations Of People With Severe Asthma." ScienceDaily. www.sciencedaily.com/releases/1999/03/990316130947.htm (accessed August 28, 2014).

Share This




More Health & Medicine News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mini Pacemaker Has No Wires

Mini Pacemaker Has No Wires

Ivanhoe (Aug. 27, 2014) Cardiac experts are testing a new experimental device designed to eliminate major surgery and still keep the heart on track. Video provided by Ivanhoe
Powered by NewsLook.com
After Cancer: Rebuilding Breasts With Fat

After Cancer: Rebuilding Breasts With Fat

Ivanhoe (Aug. 27, 2014) More than 269 million women are diagnosed with breast cancer each year. Many of them will need surgery and radiation, but there’s a new simple way to reconstruct tissue using a patient’s own fat. Video provided by Ivanhoe
Powered by NewsLook.com
Blood Clots in Kids

Blood Clots in Kids

Ivanhoe (Aug. 27, 2014) Every year, up to 200,000 Americans die from a blood clot that travels to their lungs. You’ve heard about clots in adults, but new research shows kids can get them too. Video provided by Ivanhoe
Powered by NewsLook.com
Radio Waves Knock out Knee Pain

Radio Waves Knock out Knee Pain

Ivanhoe (Aug. 27, 2014) Doctors have used radio frequency ablation or RFA to reduce neck and back pain for years. But now, that same technique is providing longer-term relief for patients with severe knee pain. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins