Featured Research

from universities, journals, and other organizations

Compound Protects Against Noise-Induced Hearing Loss In Animal Model, UB Researchers Show

Date:
April 12, 1999
Source:
University At Buffalo
Summary:
Researchers in the University at Buffalo Center for Hearing and Deafness have shown for the first time that a compound called leupeptin may help protect against the noise-induced hearing loss caused by living in noisy industrialized societies.

BUFFALO, N.Y. -- Researchers in the University at Buffalo Center for Hearing and Deafness have shown for the first time that a compound called leupeptin may help protect against the noise-induced hearing loss caused by living in noisy industrialized societies.

Using an animal model, researchers found that treating the inner ear with leupeptin before exposure to high-level noise, comparable to a jet engine, reduced the loss of sensory hair cells by 60 percent. Hair cells convert sound waves into electrical impulses that are sent to the brain.

Leupeptin, however, did not protect against the damaging effects of the anti-cancer drug carboplatin that can cause deafness in treated patients.

Results of the study, lead by Richard J. Salvi, Ph.D., professor of communicative disorders and sciences in UB's College of Arts and Sciences and co-director of the center, appear in the current issue (Vol. 10, No. 4) of NeuroReport.

"The results are very exciting for two reasons," Salvi said. "First, they provide clues to the cellular events that lead to sensory-cell death in the inner ear. Second, they suggest a potential drug-therapy approach to protecting the ear against sound damage."

Salvi and his colleagues at UB and his collaborators, Alfred Stracher, Ph.D., and Abraham Shulman, Ph.D., both at the SUNY Health Science Center at Brooklyn, have been investigating ways to protect the auditory system from damage via noise and ototoxic drugs, common causes of deafness in Western societies.

This study was based on the knowledge that, in many cases, degeneration of nerve function is caused by a cascade of events, beginning with a trauma that induces an increase of calcium in nerve cells. Excess calcium, in turn, increases the level of enzymes called calpains, which promote the breakdown of proteins and other factors critical to nerve functioning.

"Drugs that inhibit the action of calpains -- leupeptin is one -- have been shown to decrease or prevent destruction of nerve functioning that results in neuromuscular atrophy in cases of trauma or genetic disorders," Stracher noted.

Salvi and colleagues set out to determine if leupeptin also could protect the sensory hair cells in the ear from noise and ototoxic drugs such as carboplatin -- knowing that such insults cause an increase in calpains -- and thus prevent hearing loss.

The researchers treated the right cochlea of chinchillas with leupeptin for 14 days. On the fifth day, some of the animals were exposed to noise, at 100 decibels or 105 decibels. The left ears of all animals served as controls. Results from the noise exposure study showed massive loss of hair cells in the ears not treated with leupeptin, while only a few hair cells were missing in the treated ear.

A similar study, designed to determine if leupeptin would protect against hair-cell loss caused by carboplatin, showed leupeptin offered no protection, Salvi said.

Additional researchers on the study were Jain Wang and Dalian Ding, research scientists in the UB Center for Hearing and Deafness.

The research was supported in part by the Martha Entenmann Tinnitus Research Foundation.


Story Source:

The above story is based on materials provided by University At Buffalo. Note: Materials may be edited for content and length.


Cite This Page:

University At Buffalo. "Compound Protects Against Noise-Induced Hearing Loss In Animal Model, UB Researchers Show." ScienceDaily. ScienceDaily, 12 April 1999. <www.sciencedaily.com/releases/1999/04/990412074800.htm>.
University At Buffalo. (1999, April 12). Compound Protects Against Noise-Induced Hearing Loss In Animal Model, UB Researchers Show. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/1999/04/990412074800.htm
University At Buffalo. "Compound Protects Against Noise-Induced Hearing Loss In Animal Model, UB Researchers Show." ScienceDaily. www.sciencedaily.com/releases/1999/04/990412074800.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins