Featured Research

from universities, journals, and other organizations

Advance Reported In Search For Skin Cancer Treatment

Date:
June 9, 1999
Source:
University Of Notre Dame
Summary:
In a search for skin cancer treatments, chemists at the University of Notre Dame have constructed a computer model of the chemical structure of an enzyme that many organisms use to repair DNA damaged by ultraviolet light.

In a search for skin cancer treatments, chemists at the University of Notre Dame have constructed a computer model of the chemical structure of an enzyme that many organisms use to repair DNA damaged by ultraviolet light. Their findings are reported in the June 9 issue of the Journal of the American Chemical Society and are now on the journal's website at http://pubs.acs.org/journals/jacsat/index.html.

Related Articles


According to Olaf Wiest, assistant professor of chemistry and biochemistry and principal investigator, the ultimate goal of the research is to produce an artificial enzyme for human use that could repair DNA damaged by ultraviolet light in humans. Such damage leads to certain types of skin cancer, which have reached almost endemic proportions. Skin cancer is now the most common form of cancer in the United States, with an estimated 1.4 million cases diagnosed annually. According to Wiest, the number of skin cancer patients has risen steadily over the past 20 years.

The computer model provides atomic details of the binding interactions of damaged DNA and DNA photolyase, the repair enzyme of the bacterium Escherichia coli. According to Wiest, the model provides new insights into which parts of the enzyme are important for electron transfer that repairs the damage.

DNA photolyase and other mechanisms are used by many organisms, suc h as yeast and algae -- but not humans -- to protect against damage by ultraviolet light. By understanding how the protection mechanisms in these organisms work, scientists may be able to develop ways to protect humans from these types of skin cancer, Wiest says.

"To the best of our knowledge, our model is the first to explain all the pertinent experimental data -- binding and alkylation studies, spectroscopic data, rate constants and mutagenesis results -- in a consistent fashion," Wiest says. "It is of course still a model, but in the absence of an x-ray structure of the enzyme-substrate complex, it provides the framework to think about the mode of action of the enzyme, make predictions, and develop experiments to test these predictions. Such a framework was not previously available."

This research is funded by the National Institutes of Health.

###

Computer simulated pictures (not under by JACS copyright) are available at http://www.nd.edu/~owiest/photolyase/pics.html.


Story Source:

The above story is based on materials provided by University Of Notre Dame. Note: Materials may be edited for content and length.


Cite This Page:

University Of Notre Dame. "Advance Reported In Search For Skin Cancer Treatment." ScienceDaily. ScienceDaily, 9 June 1999. <www.sciencedaily.com/releases/1999/06/990609073012.htm>.
University Of Notre Dame. (1999, June 9). Advance Reported In Search For Skin Cancer Treatment. ScienceDaily. Retrieved November 22, 2014 from www.sciencedaily.com/releases/1999/06/990609073012.htm
University Of Notre Dame. "Advance Reported In Search For Skin Cancer Treatment." ScienceDaily. www.sciencedaily.com/releases/1999/06/990609073012.htm (accessed November 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, November 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com
Ebola: Life Without School in Guinea

Ebola: Life Without School in Guinea

AFP (Nov. 21, 2014) Following the closure of schools and universities in Guinea because of the Ebola virus, students look for temporary work or gather in makeshift classrooms to catch up on their syllabus. Duration: 02:14 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins