Featured Research

from universities, journals, and other organizations

National Jewish Researchers First To Identify Component In Thymus Positively Selects T Cells

Date:
July 22, 1999
Source:
National Jewish Medical And Research Center
Summary:
Researchers at National Jewish Medical and Research Center have identified what T cells “see” in a normal thymus that controls the development of functional or immune-system aggressive T cells, according to today’s issue of the journal Immunity.

DENVER-Researchers at National Jewish Medical and Research Center have identified what T cells “see” in a normal thymus that controls the development of functional or immune-system aggressive T cells, according to today’s issue of the journal Immunity.

“This is the first time anybody has described what T cells really ‘see’ when they are positively selected in the thymus,” said Uwe Staerz, M.D., Ph.D., a National Jewish researcher who studies the immune system.

This research helps expand the understanding of how the immune system develops. In the future, this research may help people who have cancer, because those with cancer don’t have fully functional immune systems. Understanding T cell development is necessary to comprehend the development of autoimmune diseases like cancer.

In the thymus, the major histocompatability complex molecule (MHC) acts as a “filter” for new T cells. Although scientists have long known that the thymus was the screening location for T cells, Dr. Staerz and a team of researchers were able to identify the specific peptide located on the MHC that positively selects T cells. A peptide called ND1, located on MHC in the thymus, was found to positively select T cells that later fight disease in the body. It’s this peptide that the T cell “sees” in the thymus.

The thymus, a small organ located in the lower neck, helps facilitate the normal development of the immune system early in life. The thymus acts as a “filter” that selects T cells with working receptors, which later sample peptides on the surface of cells. Most of the T cells that don’t have the correct receptors and can potentially attack the immune system are screened by the thymus and then destroy themselves. However, some T cells, which later may cause an autoimmune disease, pass throught the thymus because not all antigens that can be seen by T cells are present in this organ.

A positively selected T cell is allowed to pass through the thymus because it contains receptors that can identify peptides and mount an immune system response, if appropriate. T cells that attack foreign entities in the immune system roam the body looking for these peptides.

Peptides contain information about cell health and are often the first notice the immune system receives about a disease attacking the body. Peptides are brought to the surface of the cell by MHC molecules that continually sample a cell for disease.

National Jewish Medical and Research Center is the number one hospital in the United States for respiratory disease treatment, U.S. News & World Report, 1998-2000.


Story Source:

The above story is based on materials provided by National Jewish Medical And Research Center. Note: Materials may be edited for content and length.


Cite This Page:

National Jewish Medical And Research Center. "National Jewish Researchers First To Identify Component In Thymus Positively Selects T Cells." ScienceDaily. ScienceDaily, 22 July 1999. <www.sciencedaily.com/releases/1999/07/990720102228.htm>.
National Jewish Medical And Research Center. (1999, July 22). National Jewish Researchers First To Identify Component In Thymus Positively Selects T Cells. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/1999/07/990720102228.htm
National Jewish Medical And Research Center. "National Jewish Researchers First To Identify Component In Thymus Positively Selects T Cells." ScienceDaily. www.sciencedaily.com/releases/1999/07/990720102228.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins