Featured Research

from universities, journals, and other organizations

Alzheimer Protein Found Critical To Brain Development

Date:
November 2, 1999
Source:
University Of Toronto
Summary:
Researchers from Mount Sinai Hospital's Samuel Lunenfeld Research Institute and the University of Toronto have discovered that some of the proteins responsible for familial Alzheimer's disease are also critical to mammalian development. The study is published in the November 1st edition of the journal Genes and Development.

Researchers from Mount Sinai Hospital's Samuel Lunenfeld Research Institute and the University of Toronto have discovered that some of the proteins responsible for familial Alzheimer's disease are also critical to mammalian development. The study is published in the November 1st edition of the journal Genes and Development.

Related Articles


Previous work in Toronto by Dr. Peter St. George Hyslop and others has shown that the human genes Presenilin 1 (PS1) and Presenilin 2 (PS2) are responsible for certain hereditary forms of Alzheimer's. To investigate how these proteins normally function, the Lunenfeld scientists developed mice lacking PS1 and PS2. These mutant mice do not survive past the early embryonic stage of development due to multiple defects, including brain development.

"The study shows that the same proteins that malfunction late in life have a key role in the beginning of life," said study author Dr. Alan Bernstein, director of the Samuel Lunenfeld Research Institute of Toronto's Mount Sinai Hospital and professor of medical genetics at the University of Toronto.

Post-doctoral researcher Dr. Dorit Donoviel, also of the Lunenfeld, said mice were used in the study because they are genetically and biochemically similar to humans. "These observations raise the intriguing possibility that early decisions in human development can have serious effects late in life," Dr. Donoviel says. "These mice will provide a valuable biological tool with which to understand the function of the molecules implicated in Alzheimer's Disease."

According to the Alzheimer Society of Canada there is no known cure for the disease that destroys vital nerve cells in the brain. Alzheimer Disease is the most common form of dementia, which affects 316,500 Canadians. The number is expected to grow to 750,000 Canadians affected by the year 2031.

The other study authors are: Anna-Katerina Hadjantonakis, Samuel Lunenfeld Research Institute of Mount Sinai Hospital; Masaki Ikeda, Centre for Research in Neurodegenerative Diseases and department of medicine, division of neurology, University of Toronto; Hui Zheng, Merck Research Laboratories, Rahway, New Jersey; Peter St. George Hyslop, Centre for Research in Neurodegenerative Diseases and department of medicine, division of neurology, University of Toronto and Toronto Western Hospital.

CONTACT:
Steven de Sousa
U of T Public Affairs
(416) 978-5949
steven.desousa@utoronto.ca

Rob Andrusevich
Mount Sinai Hospital
(416) 586-3161
randrusevich@mtsinai.on.ca


Story Source:

The above story is based on materials provided by University Of Toronto. Note: Materials may be edited for content and length.


Cite This Page:

University Of Toronto. "Alzheimer Protein Found Critical To Brain Development." ScienceDaily. ScienceDaily, 2 November 1999. <www.sciencedaily.com/releases/1999/11/991101100458.htm>.
University Of Toronto. (1999, November 2). Alzheimer Protein Found Critical To Brain Development. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/1999/11/991101100458.htm
University Of Toronto. "Alzheimer Protein Found Critical To Brain Development." ScienceDaily. www.sciencedaily.com/releases/1999/11/991101100458.htm (accessed October 30, 2014).

Share This



More Mind & Brain News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Studying Effects of Music on Dementia Patients

Studying Effects of Music on Dementia Patients

AP (Oct. 30, 2014) The University of Wisconsin-Milwaukee is studying the popular Music and Memory program to see if music, which helps improve the mood of Alzheimer's patients, can also reduce the use of prescription drugs for those suffering from dementia. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Techy Tots Are Forefront of London's Baby Show

Techy Tots Are Forefront of London's Baby Show

AP (Oct. 28, 2014) Moms and Dads get a more hands-on approach to parenting with tech-centric products for raising their little ones. (Oct. 28) Video provided by AP
Powered by NewsLook.com
Cocoa Could Be As Good For Memory As It Is For A Sweet Tooth

Cocoa Could Be As Good For Memory As It Is For A Sweet Tooth

Newsy (Oct. 27, 2014) Researchers have come up with another reason why dark chocolate is good for your health. A substance in the treat can reportedly help with memory. Video provided by Newsy
Powered by NewsLook.com
Five-Year-Olds Learn Coding as Britain Eyes Digital Future

Five-Year-Olds Learn Coding as Britain Eyes Digital Future

AFP (Oct. 27, 2014) Coding has become compulsory for children as young as five in schools across the UK. Making it the first major world economy to overhaul its IT teaching and put programming at its core. Duration: 02:19 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins