Featured Research

from universities, journals, and other organizations

"Untangling" Tau: New Mouse Model Shows Key Feature Of Alzheimer's Disease

Date:
November 25, 1999
Source:
NIH-National Institute On Aging
Summary:
Scientists have succeeded in producing a hallmark of Alzheimer's disease in a laboratory animal model. The much-anticipated transgenic mouse model is genetically-engineered with the human gene coding for a form of the brain protein tau. The new mouse strain will enable investigators to study tau-containing lesions in a number of brain disorders, including the insoluble tau-containing tangles that build up and form one of the key pathological features of Alzheimer's disease (AD).

Scientists have succeeded in producing a hallmark of Alzheimer's disease in a laboratory animal model. The much-anticipated transgenic mouse model is genetically-engineered with the human gene coding for a form of the brain protein tau. The new mouse strain will enable investigators to study tau-containing lesions in a number of brain disorders, including the insoluble tau-containing tangles that build up and form one of the key pathological features of Alzheimer's disease (AD). It joins several other partial models of Alzheimer's disease and may help to hasten the development of potential treatments for AD. The National Institute on Aging (NIA) funded the study, which appears in this month's issue of the journal Neuron.*

In the study, scientists inserted human tau genes into mice which later developed masses of abnormal tau filaments in nerve cells within the spinal cord, cortex and brainstem, three critical regions of the central nervous system. As the mice aged, insoluble masses of tau filaments grew in number. The animals also showed evidence of nerve cell degeneration and impaired movement, unlike their littermates lacking the inserted tau gene. The strain was created under the direction of Virginia M-Y. Lee, Ph.D., M.B.A., and John Q. Trojanowski, M.D., Ph.D. at the University of Pennsylvania's Center for Neurodegenerative Disease Research in Philadelphia.

The mice do not completely model AD, but they more closely resemble other human brain diseases that accumulate AD-like tau deposits in regions deep within the central nervous system, Dr. Lee is careful to point out.

"We know that tau-containing tangles are an important feature of Alzheimer's disease, but we're not sure about how it fits into the development and progression of the disease, so the tau mouse model is very important," says Dr. D. Stephen Snyder, who directs studies of the Etiology of Alzheimer's Disease at NIA's Neuroscience and Neuropsychology of Aging Program. "It should help us look at normal and abnormal tau function, for example, to study and measure the accumulation of tau and to determine how the known mutations lead to the death of neurons. Less clear is whether tau will eventually prove to be a useful diagnostic marker for the tauopathies and, importantly, for AD."

The two neuropathlogical hallmarks of Alzheimer's disease are senile plaques, which are made of a protein fragment called beta amyloid, and neurofibrillary tangles, which are made of abnormal twisted strands of the protein, tau. Tau formation is related to the severity of disease; the more advanced the stage of disease, the more tau deposits in the brain. Animal models already exist for other features of Alzheimer's disease, including strains bred with mutated forms of the human amyloid precursor protein, which causes amyloid to form, and mice bred with the presenilin and apoE4 genes, also implicated in Alzheimer's disease.

Dementia refers to a loss of memory and reasoning and specifically to a progressive deterioration that is severe enough to prevent normal functioning. AD is the most common cause of dementia among people age 65 and older. AD affects as many as 4 million Americans in the United States. The prevalence of AD doubles every 5 years beyond age 65. Some studies indicate that nearly half of all people age 85 and older have symptoms of AD.

Researchers use the term "tauopathy" to describe a grouping of dementing diseases in which tau is implicated, such as a unique form of dementia which involves several mutations in the tau gene affecting over twenty distinct families. They also include Pick's disease and progressive supranuclear palsy (PSP), which are not caused by tau genetic mutations. Tauopathies differ from AD in a number of important ways. Clinical signs associated with tauopathies vary widely and range from schizophrenia and Parkinsonian-like tremors to language and behavioral disturbances. In addition, people with tauopathies may have abundant AD-like deposits of tau filaments, but they may not have deposits of beta amyloid. Masses of tau filaments accumulate in different brain regions from those affected by AD and the tau filaments themselves often have a slightly different structure from those in AD. And because memory loss in some tauopathies is similar to that experienced by patients with AD, the prevalence of tauopathies - distinct from AD - remains uncertain.

Scientists do not yet know how tau and amyloid deposits form, or how they cause cells to die in AD. The two may form independently of one another, or one before the other. Scientists are also working to understand how the two produce disease in the brain, and to understand why and how tau deposits accumulate. But they know that the protein is critical to cell survival and helps maintain the cell's internal support structure or cytoskeleton.

The NIA is the lead federal agency supporting and conducting Alzheimer's disease research, including studies of the basic, clinical, and epidemiological aspects of this and other related dementias of aging. The NIA's Alzheimer's Disease Education and Referral (ADEAR) Center can provide more information on Alzheimer's disease by calling 1-800-438-4380 or visiting the ADEAR Web site at http://www.alzheimers.org.


Story Source:

The above story is based on materials provided by NIH-National Institute On Aging. Note: Materials may be edited for content and length.


Cite This Page:

NIH-National Institute On Aging. ""Untangling" Tau: New Mouse Model Shows Key Feature Of Alzheimer's Disease." ScienceDaily. ScienceDaily, 25 November 1999. <www.sciencedaily.com/releases/1999/11/991125090907.htm>.
NIH-National Institute On Aging. (1999, November 25). "Untangling" Tau: New Mouse Model Shows Key Feature Of Alzheimer's Disease. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/1999/11/991125090907.htm
NIH-National Institute On Aging. ""Untangling" Tau: New Mouse Model Shows Key Feature Of Alzheimer's Disease." ScienceDaily. www.sciencedaily.com/releases/1999/11/991125090907.htm (accessed July 25, 2014).

Share This




More Mind & Brain News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins