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"Untangling" Tau: New Mouse Model Shows Key Feature Of Alzheimer's Disease

Date:
November 25, 1999
Source:
NIH-National Institute On Aging
Summary:
Scientists have succeeded in producing a hallmark of Alzheimer's disease in a laboratory animal model. The much-anticipated transgenic mouse model is genetically-engineered with the human gene coding for a form of the brain protein tau. The new mouse strain will enable investigators to study tau-containing lesions in a number of brain disorders, including the insoluble tau-containing tangles that build up and form one of the key pathological features of Alzheimer's disease (AD).

Scientists have succeeded in producing a hallmark of Alzheimer's disease in a laboratory animal model. The much-anticipated transgenic mouse model is genetically-engineered with the human gene coding for a form of the brain protein tau. The new mouse strain will enable investigators to study tau-containing lesions in a number of brain disorders, including the insoluble tau-containing tangles that build up and form one of the key pathological features of Alzheimer's disease (AD). It joins several other partial models of Alzheimer's disease and may help to hasten the development of potential treatments for AD. The National Institute on Aging (NIA) funded the study, which appears in this month's issue of the journal Neuron.*


Story Source:

The above story is based on materials provided by NIH-National Institute On Aging. Note: Materials may be edited for content and length.


Cite This Page:

NIH-National Institute On Aging. ""Untangling" Tau: New Mouse Model Shows Key Feature Of Alzheimer's Disease." ScienceDaily. ScienceDaily, 25 November 1999. <www.sciencedaily.com/releases/1999/11/991125090907.htm>.
NIH-National Institute On Aging. (1999, November 25). "Untangling" Tau: New Mouse Model Shows Key Feature Of Alzheimer's Disease. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/1999/11/991125090907.htm
NIH-National Institute On Aging. ""Untangling" Tau: New Mouse Model Shows Key Feature Of Alzheimer's Disease." ScienceDaily. www.sciencedaily.com/releases/1999/11/991125090907.htm (accessed April 24, 2014).

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