Featured Research

from universities, journals, and other organizations

Scientists Use Salmonella To Fight Cancer In First Human Trials

Date:
December 13, 1999
Source:
Yale University
Summary:
A genetically engineered strain of the bacteria Salmonella has been administered to the first cancer patients enrolled in a Phase I intratumoral clinical trial. The concept, developed by Yale Cancer Center researchers and licensed to Vion Pharmaceuticals in New Haven, Conn., involves the use of engineered strains of the common Salmonella bacterium, the same bacterium that, in its unaltered or wild type form, can cause food poisoning and septic shock.

(NEW HAVEN) -- A genetically engineered strain of the bacteria Salmonella has been administered to the first cancer patients enrolled in a Phase I intratumoral clinical trial. The patients were initially monitored in the hospital and subsequently discharged.

The concept, developed by Yale Cancer Center researchers and licensed to Vion Pharmaceuticals in New Haven, Conn., involves the use of engineered strains of the common Salmonella bacterium, the same bacterium that, in its unaltered or wild type form, can cause food poisoning and septic shock. The altered Salmonella, stripped of its pathogenicity, has been shown to target solid tumors and inhibit their growth in laboratory animals.

The key is that the safe versions are still able to target solid tumors in laboratory animals, much like the wild type parent, while at the same time have little or no adverse effects. "We have shown that we can significantly prolong the life of mice with melanoma by injecting them with our attenuated bacteria," said John M. Pawelek, Ph.D., senior research scientist in dermatology and a lecturer in pharmacology at the Yale University School of Medicine. "These preliminary results with animals are encouraging. We would now like to see the same outcome in people."

Collaborating with Pawelek on this novel approach to fighting cancer are K. Brooks Low, Ph.D., a bacterial geneticist and professor of research in therapeutic radiology at Yale, and former Yale colleague David Bermudes, Ph.D., now a senior scientist working on the Salmonella project at Vion.

Potential safety and efficacy will continue to be monitored according to the protocol. The study is designed to evaluate the safety, potential efficacy and optimum biological dose of the bacterial vector for patients with either cutaneous or subcutaneous solid tumors. Patient accrual for the trial is continuing.

###

The Yale Cancer Center is one of a select network of comprehensive cancer centers in the country designated by the National Cancer Institute and the only one in Southern New England. Bringing together the resources of Yale-New Haven Hospital and the Yale University School of Medicine, its mission encompasses patient care, research, cancer prevention and control, community outreach and education.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Scientists Use Salmonella To Fight Cancer In First Human Trials." ScienceDaily. ScienceDaily, 13 December 1999. <www.sciencedaily.com/releases/1999/12/991213051204.htm>.
Yale University. (1999, December 13). Scientists Use Salmonella To Fight Cancer In First Human Trials. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/1999/12/991213051204.htm
Yale University. "Scientists Use Salmonella To Fight Cancer In First Human Trials." ScienceDaily. www.sciencedaily.com/releases/1999/12/991213051204.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins