Featured Research

from universities, journals, and other organizations

Researchers Discover New Vein Of Cancer-Fighting Agents

Date:
January 10, 2000
Source:
Beth Israel Deaconess Medical Center
Summary:
Researchers at Beth Israel Deaconess Medical Center have discovered a potent new substance that thwarts tumor growth by blocking the formation and growth of new blood vessels. The naturally occurring protein is named "canstatin" for its potential cancer-halting abilities.

Canstatin inhibits new blood vessel growth, suppresses renal, prostate tumor growth in mice

BOSTON -- Researchers at Beth Israel Deaconess Medical Center have discovered a potent new substance that thwarts tumor growth by blocking the formation and growth of new blood vessels. The naturally occurring protein is named "canstatin" for its potential cancer-halting abilities.

In a mouse model of human prostate cancer, canstatin was as effective at less than half the dose as the well-known angiogenic inhibitor endostatin in halting the growth of tumors. In mice models of renal cancer, canstatin stopped the growth or slightly shrank tumors to as much as one-fourth the size of tumors in mice treated with a placebo. The paper is published in the Jan. 14 issue of the Journal of Biological Chemistry (published online Jan. 7 at www.jbc.org).

This is the first in a series of new angiogenic inhibitors discovered in the blood vessel wall by BIDMC researcher Raghu Kalluri and his colleagues. In addition to its preliminary promise as a cancer-fighting agent, canstatin is also relatively easy to produce in quantities that will be necessary for human clinical trials, which may begin in one or two years after further preclinical testing.

"Tumors are highly dependent on new blood vessels for their growth, and canstatin appears to stop the division of endothelial cells as they begin multiplying to form new blood vessels," says Kalluri, who is also an assistant professor of medicine at Harvard Medical School. "The agent stops them from multiplying by inducing programmed cell death only in the dividing cells, not in the non-dividing endothelial cells in established blood vessels. The tumor stops growing because it doesn't get any new blood supply or nutrients."

During the process of angiogenesis, endothelial cells that line inside of the blood vessel divide, move through the surrounding vessel walls, and form tubes that will become new capillaries. Other experiments by Kalluri and his colleagues show that canstatin can also inhibit the migration and tube formation of endothelial cells. The results suggest that the inhibitor may work at more than one step in the angiogenesis process.

"I do not believe any angiogenic inhibitor will be used as a single agent to fight cancer," Kalluri says. "They're potentially powerful drugs for controlling tumor growth, but for complete control of cancer angiogenic inhibitors probably will have to be used in combination with existing therapies, such as radiation and chemotherapy."

Other authors on the paper include postdoctoral fellow George Kamphaus, Ph.D., postdoctoral fellow Pablo Colorado, Ph.D., postdoctoral fellow David Panka, Ph.D., postdoctoral fellow Helmut Hopfer, Ph.D., postdoctoral fellow Ramani Ramchandran, Ph.D., technician Adriana Torre, postdoctoral fellow Yohei Maeshima, M.D., Ph.D., associate professor James Mier M.D., and BIDMC renal division chief and professor Vikas Sukhatme, M.D., Ph.D..

In July 1999, Beth Israel Deaconess Medical Center licensed its intellectual property rights in canstatin and four other angiogenic inhibitors derived from vascular basement membrane to ILEX Oncology, a publicly traded drug development company in San Antonio. Kalluri, Sukhatme and BIDMC all own equity in ILEX, which is developing canstatin and other compounds as cancer treatments to be used in combination with radiation and chemotherapy.

The research was funded in part by National Institutes of Health, Hershey Prostate Cancer Research award, American Society of Nephrology, National Kidney Foundation, and Beth Israel Deaconess Medical Center.


Story Source:

The above story is based on materials provided by Beth Israel Deaconess Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Beth Israel Deaconess Medical Center. "Researchers Discover New Vein Of Cancer-Fighting Agents." ScienceDaily. ScienceDaily, 10 January 2000. <www.sciencedaily.com/releases/2000/01/000110071354.htm>.
Beth Israel Deaconess Medical Center. (2000, January 10). Researchers Discover New Vein Of Cancer-Fighting Agents. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2000/01/000110071354.htm
Beth Israel Deaconess Medical Center. "Researchers Discover New Vein Of Cancer-Fighting Agents." ScienceDaily. www.sciencedaily.com/releases/2000/01/000110071354.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins