Featured Research

from universities, journals, and other organizations

Water: The Unexpected Blood Pressure Drug

Date:
February 8, 2000
Source:
Vanderbilt University Medical Center
Summary:
Patients who suffer from autonomic nervous system failure can turn to a new treatment for their blood pressure abnormalities: a large glass of water. Investigators at Vanderbilt's Autonomic Dysfunction Center report in the February 8th issue of the journal Circulation that water has a powerful blood pressure raising effect in these patients.

Patients who suffer from autonomic nervous system failure can turn to a new treatment for their blood pressure abnormalities: a large glass of water. Investigators at Vanderbilt's Autonomic Dysfunction Center report in the February 8th issue of the journal Circulation that water has a powerful blood pressure raising effect in these patients.

Water also raises blood pressure in older normal subjects, but not in young normal subjects. The studies suggest that water is an important unrecognized factor in clinical studies of blood pressure medications.

"Water is not just a neutral substance, and it cannot be considered a 'placebo' with regards to blood pressure," said Dr. John R. Shannon, instructor of Medicine and Pharmacology. "As physicians, we may ask our hypertensive patients if they just drank a cup of coffee or smoked a cigarette when we measure their blood pressure, but we would never think to ask if they had anything to drink in the last hour. Perhaps we should. It might make the difference in whether or not we adjust their medications."

On the average, 16 ounces of tap water raised blood pressure about 40 millimeters of mercury in patients with autonomic failure. Blood pressure started increasing within two or three minutes after the water was ingested, increased rapidly over the next 15 minutes, and then began to decrease after about 60 minutes. Drinking more water at 60 minutes caused the blood pressure effect to be sustained for another hour.

In older normal subjects, the average increase in blood pressure was 11 millimeters of mercury.

There is something about the water itself that causes the increase in blood pressure; intravenous infusion of 16 ounces of sugar solution did not elicit the effect. In addition, the effect is "dose-dependent" -- the higher the water intake, the larger the increase in blood pressure.

"We do not know how water raises blood pressure, but it is the solute-free water itself, whether warm, room temperature, or cold that elicits the effect," said Dr. Jens Jordan, a former postdoctoral fellow in Clinical Pharmacology and lead author of the study.

"Water might be increasing blood pressure by interacting with osmoreceptors (which sense salt concentrations) or stretch receptors in the stomach or liver," added Jordan, who is currently director of the Clinical Research Center at the Franz Volhard Klinik of Humboldt University in Berlin, Germany.

The studies suggest a new and more effective treatment for the blood pressure abnormalities suffered by patients with autonomic failure. By raising blood pressure, water ingestion during the day can enhance a patient's functional abilities. At Vanderbilt, the careful administration and withholding of water at various times during the day has proven successful as the only form of blood pressure treatment for some patients with autonomic failure.

Although further work is required to understand why water raises blood pressure in older normal subjects, the studies suggest that physicians need to be aware of water as a variable to consider in assessing blood pressure levels. In addition, water intake is a variable that needs to be controlled in short-term pharmacological studies of drugs that increase and decrease blood pressure.


Story Source:

The above story is based on materials provided by Vanderbilt University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Vanderbilt University Medical Center. "Water: The Unexpected Blood Pressure Drug." ScienceDaily. ScienceDaily, 8 February 2000. <www.sciencedaily.com/releases/2000/02/000208075311.htm>.
Vanderbilt University Medical Center. (2000, February 8). Water: The Unexpected Blood Pressure Drug. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2000/02/000208075311.htm
Vanderbilt University Medical Center. "Water: The Unexpected Blood Pressure Drug." ScienceDaily. www.sciencedaily.com/releases/2000/02/000208075311.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins