Amyotrophic Lateral Sclerosis News
July 7, 2015

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updated 6:26pm EDT

More Amyotrophic Lateral Sclerosis News
July 7, 2015

May 22, 2015 — A novel mouse has been developed that exhibits the symptoms and neurodegeneration associated with the most common genetic forms of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis ... read more

Newer Method of Oxygen Delivery for Patients at Risk of Respiratory Failure After Surgery

May 17, 2015 — A relatively new, easier to implement, and better-tolerated method to provide supplemental oxygen to patients at risk of respiratory failure after surgery did not result in a worse rate of treatment ... read more

Mar. 23, 2015 — Where ALS comes from and how it progresses are mysteries that continue to vex medical science. But recent research has found three proteins that could shed some light on the mechanisms behind this ... read more

Why Upper Motor Neurons Degenerate in ALS

Jan. 28, 2015 — Scientists have revealed a mechanism underlying the cellular degeneration of the upper motor neurons that die in ALS, and developed a model system that will allow further research on the ... read more

Drug for Lou Gehrig’s Disease Boosts Radiation Effectiveness in Melanoma Laboratory Models With Brain Metastasis

Jan. 12, 2015 — A drug used to treat Lou Gehrig's disease (ALS) helps radiation be more effective when it was administered to laboratory models with melanoma that had metastasized to the brain, researchers have ... read more

Dec. 22, 2014 — Forgetfulness, it turns out, is all in the head. Scientists have shown that fading memory and clouding judgment, the type that comes with advancing age, show up as lost and altered connections ... read more

Unpacking Brain Damage in ALS

Dec. 17, 2014 — Researchers gain new insight into how motor neurons in the brain die during ALS. About 5 percent of ALS patients carry an altered version of a gene called C9orf72, which in ALS patients contains ... read more

More Patients With Lou Gehrig's Disease Have Genetic Origin Than Previously Thought

Dec. 5, 2014 — Genetics may play a larger role in causing Lou Gehrig’s disease than previously believed, potentially accounting for more than one-third of all cases, according to one of the most comprehensive ... read more

Calcium-Induced Conformational Changes of the Regulatory Domain of Human Mitochondrial Aspartate/glutamate Carriers

Nov. 25, 2014 — Structures of human mitochondrial aspartate/glutamate carrier regulatory domains reveal the nature of calcium-dependent conformational ... read more

New Approach for Treating ALS: Re-Evaluation of Older Drugs?

Nov. 20, 2014 — Blocking molecules involved in ALS-drug resistance may improve how well ALS therapeutics work, suggesting that re-evaluation of drugs that appeared to have failed might be ... read more

Genotype Found in 30 Percent of Als Patients Speeds Up Disease Progression

Nov. 13, 2014 — Mice bred to carry a gene variant found in a third of ALS patients have a faster disease progression and die sooner than mice with the standard genetic model of the disease, according to researchers. ... read more

Study of Lou Gehrig's Disease Shifts 'Origin' Focus to Brain's Motor Neurons

Nov. 11, 2014 — Lou Gehrig’s disease, also known as amyotrophic lateral sclerosis, or ALS, might damage muscle-controlling nerve cells in the brain earlier in the disease process than previously known, according ... read more

ACE-Inhibitors Associated With Lower Risk for ALS Above Certain Dose Over Time

Nov. 10, 2014 — ALS is a progressive neurodegenerative disease and most patients die within three to five years after symptoms appear. Studies have suggested antihypertensive medications angiotensin-converting ... read more

Lou Gehrig's Disease Study: Renewing Brain's Aging Support Cells May Help Neurons Survive

Oct. 30, 2014 — Lou Gehrig’s disease, also known as amyotrophic lateral sclerosis, or ALS, attacks muscle-controlling nerve cells – motor neurons – in the brain, brainstem and spinal cord. Patients typically ... read more

Oct. 26, 2014 — Digoxin, a medication used in the treatment of heart failure, may be adaptable for the treatment of amyotrophic lateral sclerosis, a progressive, paralyzing disease, suggests new ... read more

ALS Is a Protein Aggregation Disease, Research Shows

Oct. 23, 2014 — Using a technique that illuminates subtle changes in individual proteins, chemistry researchers have uncovered new insight into the underlying causes of Amyotrophic Lateral Sclerosis ... read more

New ALS Associated Gene Identified Using Innovative Strategy

Oct. 22, 2014 — Using an innovative exome sequencing strategy, a team of international scientists has shown that TUBA4A, the gene encoding the Tubulin Alpha 4A protein, is associated with familial amyotrophic ... read more

Oct. 14, 2014 — A potential cause of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, has been suggested by researchers who focused on the effects of mutations to a gene coding for a ... read more

Sep. 24, 2014 — The first animal model for ALS dementia, a form of ALS that also damages the brain, has been developed by scientists. The advance will allow researchers to directly see the brains of living mice, ... read more

Mitochondria's Role in Neurodegenerative Diseases Clearer Thanks to Mouse Study

Sep. 19, 2014 — A new study sheds light on a longstanding question about the role of mitochondria in debilitating and fatal motor neuron diseases and resulted in a new mouse model to study such illnesses. ... read more

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