Featured Research

from universities, journals, and other organizations

Memory Loss May Be Reversed With New Treatment Developed At Yale

Date:
March 17, 2000
Source:
Yale University
Summary:
Working memory loss can be reversed using a short-term drug regimen that produces long-lasting effects, a Yale study has found. Results from this study led by Stacy Castner at Yale School of Medicine may ultimately lead to new treatment strategies for those who have lost working or short-term memory.

Study Offers Hope for Patients With Age-Related Memory Loss and Disorders Such as Parkinson's and Schizophrenia

Related Articles


New Haven, Conn. -- Working memory loss can be reversed using a short-term drug regimen that produces long-lasting effects, a Yale study has found.

Results from this study led by Stacy Castner at Yale School of Medicine may ultimately lead to new treatment strategies for those who have lost working or short-term memory. The team's past studies suggest that long-term treatment with antipsychotic medications for diseases such as schizophrenia, decrease the number of D1 receptors in cortical neurons. D1 receptors are one of five known dopamine receptors, which control memory function.

Published in the March 17 issue of Science, results from this new study show that long-term treatment with antipsychotic drugs produces memory impairments when the treatment lasts over several months.

"We also found that the memory deficits produced by anti-psychotic drugs can be reversed by stimulating D1 receptors with a D1 agonist-a drug that stimulates mainly D1 receptors," said Castner, associate research scientist at Yale School of Medicine.

The D1 agonist used in the study was ABT-431, an experimental and not yet available drug which effectively reversed memory loss in six primates. The improvements have been sustained for more than a year.

The return of short-term memory, which is often lost due to age and diseases such as schizophrenia and Parkinson's, is critical because short-term memory allows individuals to briefly hold information in mind while the knowledge is processed to determine an appropriate action.

It only took a relatively short treatment regimen of 25 days to get a positive effect, and it could be even shorter with the same effect, said Castner. The improvement in memory persisted for months and years after the last treatment, suggesting that the state of the circuitry involved in memory processing had been permanently or semi-permanently restored to a different level of sensitivity.

Castner's team included Patricia Goldman-Rakic and Graham V. Williams in the section of neurobiology at Yale School of Medicine. The research was supported by Hoechst Marion Rousell (now Aventis Pharmaceuticals); the National Institute of Mental Health; and the National Institute on Drug Abuse.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Memory Loss May Be Reversed With New Treatment Developed At Yale." ScienceDaily. ScienceDaily, 17 March 2000. <www.sciencedaily.com/releases/2000/03/000317052438.htm>.
Yale University. (2000, March 17). Memory Loss May Be Reversed With New Treatment Developed At Yale. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2000/03/000317052438.htm
Yale University. "Memory Loss May Be Reversed With New Treatment Developed At Yale." ScienceDaily. www.sciencedaily.com/releases/2000/03/000317052438.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Technology Is Ruining Snow Days For Students

How Technology Is Ruining Snow Days For Students

Newsy (Jan. 25, 2015) More schools are using online classes to keep from losing time to snow days, but it only works if students have Internet access at home. Video provided by Newsy
Powered by NewsLook.com
Weird Things Couples Do When They Lose Their Phone

Weird Things Couples Do When They Lose Their Phone

BuzzFeed (Jan. 24, 2015) Did you back it up? Do you even know how to do that? Video provided by BuzzFeed
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com
Amazing Technology Allows Blind Mother to See Her Newborn Son

Amazing Technology Allows Blind Mother to See Her Newborn Son

RightThisMinute (Jan. 23, 2015) Not only is Kathy seeing her newborn son for the first time, but this is actually the first time she has ever seen a baby. Kathy and her sister, Yvonne, have been legally blind since childhood, but thanks to an amazing new technology, eSight glasses, which gives those who are legally blind the ability to see, she got the chance to see the birth of her son. It&apos;s an incredible moment and an even better story. Video provided by RightThisMinute
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins