Featured Research

from universities, journals, and other organizations

Blocking Growth Factor Halts Tumor Advance, Spread In Mice

Date:
May 22, 2000
Source:
Columbia University College Of Physicians And Surgeons
Summary:
Researchers at Columbia have found that blocking the interaction of two naturally occurring molecules in tumor cells restricts the growth and spread of neoplasms in mice. The finding, published in the May 18 issue of the journal Nature, suggests a similar approach may be helpful in treating human cancers.

Researchers at Columbia have found that blocking the interaction of two naturally occurring molecules in tumor cells restricts the growth and spread of neoplasms in mice. The finding, published in the May 18 issue of the journal Nature, suggests a similar approach may be helpful in treating human cancers.

Drs. Ann Marie Schmidt and David Stern, from the Department of Surgery, and their colleagues at the College of Physicians and Surgeons along with researchers from the Osaka University School of Medicine and the Kanazawa University School of Medicine, are investigating the receptor for advanced glycation endproducts (RAGE). This receptor, found on the surface of many types of cells, interacts with several different molecules (termed ligands) that play a role in both health and disease. Some of these molecules are involved in development, maintenance of normal cellular functions, and inflammation, while others have been implicated in diabetes and Alzheimer's disease.

Drs. Schmidt and Stern and their colleagues investigated one ligand in particular, amphoterin. Normally, when RAGE and amphoterin interact they trigger intracellular processes likely to be involved in normal development. But sustained RAGE-amphoterin interaction in the context of tumors is shown to promote rapid proliferation, cell migration and invasion. The researchers studied whether blocking RAGE and amphoterin from interaction would have any effect on tumor behavior.

They employed several different strategies for blocking this interaction using tumor models in laboratory mice. The first model used local injection of glioma cells, derived from a tumor of the nervous system, to develop tumors on the backs of mice. Blockade of RAGE-amphoterin interaction by several methods strikingly decreased tumor size. The second model was one of distant tumor spread, or metastasis. In this model, blocking RAGE strongly suppressed lung metastasis. The third model used genetically manipulated mice prone to the development of skin tumors called papillomas. Preventing access of ligands to RAGE in these mice decreased the number and size of the papillomas.

Inhibition of RAGE-amphoterin interaction appeared to exert its effect on the tumor cells by decreasing tumor cell growth, migration and invasion. This inhibition did not kill tumor cells, nor did it affect the growth of blood vessels into the tumor, which is known as angiogenesis. Thus, Drs. Schmidt and Stern suspect that combining RAGE blockade with cell-destroying and anti-angiogenic therapies might provide even more potent anti-tumor therapy. However, the authors point out that it is essential to interpret their data cautiously in the broader context of tumor behavior in humans, since the studies to date have only been performed in selected mouse models.


Story Source:

The above story is based on materials provided by Columbia University College Of Physicians And Surgeons. Note: Materials may be edited for content and length.


Cite This Page:

Columbia University College Of Physicians And Surgeons. "Blocking Growth Factor Halts Tumor Advance, Spread In Mice." ScienceDaily. ScienceDaily, 22 May 2000. <www.sciencedaily.com/releases/2000/05/000519064607.htm>.
Columbia University College Of Physicians And Surgeons. (2000, May 22). Blocking Growth Factor Halts Tumor Advance, Spread In Mice. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2000/05/000519064607.htm
Columbia University College Of Physicians And Surgeons. "Blocking Growth Factor Halts Tumor Advance, Spread In Mice." ScienceDaily. www.sciencedaily.com/releases/2000/05/000519064607.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins