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Anti-Angiogenic Drug Much More Effective When Immune System Primed Against Cancer

Date:
June 13, 2000
Source:
University Of Pittsburgh Medical Center
Summary:
Agents that starve tumors by cutting off their blood supply have come to the forefront in experimental cancer therapies within recent years. Promising though they are, these anti-angiogenic drugs are no magic bullet. When treatment with them is discontinued in experimental models, tumors rebound because small pockets of viable cancer cells remain. Now, University of Pittsburgh scientists have shown that triggering an anti-tumor immune response significantly potentiates the effects of the anti-angiogenic drug endostatin in animal models, leading to permanent and complete regression in half of treated animals.

PITTSBURGH, June 9 - Agents that starve tumors by cutting off their blood supply have come to the forefront in experimental cancer therapies within recent years. Promising though they are, these anti-angiogenic drugs are no magic bullet. When treatment with them is discontinued in experimental models, tumors rebound because small pockets of viable cancer cells remain. Now, University of Pittsburgh scientists have shown that triggering an anti-tumor immune response significantly potentiates the effects of the anti-angiogenic drug endostatin in animal models, leading to permanent and complete regression in half of treated animals. These results are being presented Sunday, June 11, at the Era of Hope/Department of Defense breast cancer meeting in Atlanta.


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The above story is based on materials provided by University Of Pittsburgh Medical Center. Note: Materials may be edited for content and length.


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University Of Pittsburgh Medical Center. "Anti-Angiogenic Drug Much More Effective When Immune System Primed Against Cancer." ScienceDaily. ScienceDaily, 13 June 2000. <www.sciencedaily.com/releases/2000/06/000612084128.htm>.
University Of Pittsburgh Medical Center. (2000, June 13). Anti-Angiogenic Drug Much More Effective When Immune System Primed Against Cancer. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2000/06/000612084128.htm
University Of Pittsburgh Medical Center. "Anti-Angiogenic Drug Much More Effective When Immune System Primed Against Cancer." ScienceDaily. www.sciencedaily.com/releases/2000/06/000612084128.htm (accessed April 20, 2014).

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