Featured Research

from universities, journals, and other organizations

Combinaton Of Radiation And Hormone Suppression Therapy Shown To Effectively Treat Early-Stage Prostate Cancer

Date:
September 25, 2000
Source:
Dana-Farber Cancer Institute
Summary:
In the first study of its kind, researchers at Brigham and Women's Hospital (BWH) and Dana-Farber Cancer Institute (DFCI) have found that combined radiation therapy (RT) and androgen suppression therapy (AST) is a more effective treatment for localized, early-stage prostate cancer compared to treatment using radiation therapy alone.

Results similar to success in treating advanced-stage cancers

BOSTON -- In the first study of its kind, researchers at Brigham and Women's Hospital (BWH) and Dana-Farber Cancer Institute (DFCI) have found that combined radiation therapy (RT) and androgen suppression therapy (AST) is a more effective treatment for localized, early-stage prostate cancer compared to treatment using radiation therapy alone. The findings are published in the September 13th issue of JAMA (Journal of the American Medical Association).

"Previous studies have shown a benefit to treating advanced-stage prostate cancer with radiation and hormone therapy," said Anthony V. D'Amico, MD, PhD, of BWH and DFCI. "This is the first study to show that the combination treatment may also benefit people with early-stage cancer."

Prostate cancer is the second leading cause of cancer death among men in this country. The American Cancer Society estimates that about 184,500 American men will be diagnosed with the disease this year and 39,200 will die.

In the study, researchers compared the relative risk of prostate specific antigen (PSA) failure during a five-year period in men who underwent RT and AST as treatment for diagnosed early-stage prostate cancer compared with men who received RT.

Although no significant difference between treatment groups was found in patients in the low-risk category, men who were classified in the intermediate-risk group and received both therapies for their cancer were five times less likely to have PSA failure than men who received RT alone. For men in the high-risk group who received both RT and AST, the effectiveness of combination therapy was more profound; they were two and one-half times less likely to have PSA failure than men who had received RT. "While further research is needed, it appears that the one-two punch of RT and AST may be a more effective treatment in the battle against both advanced-stage and early-stage prostate cancer," added Dr. D'Amico.

The 1,586 study participants were categorized using a combination of their PSA levels, biopsy Gleason score, and stage of tumor into three groups. All patients in the study had cancer that was localized to the prostate by rectal exam. The more aggressive the participant's tumor, the higher the risk category in which he was placed. The men's cancers were treated using a three-dimensional conformal RT with or without AST.

AST is a type of hormonal therapy that is often used in all phases of prostate cancer treatment to help block production or action of the male hormones that have been shown to fuel prostate cancer.


Story Source:

The above story is based on materials provided by Dana-Farber Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Dana-Farber Cancer Institute. "Combinaton Of Radiation And Hormone Suppression Therapy Shown To Effectively Treat Early-Stage Prostate Cancer." ScienceDaily. ScienceDaily, 25 September 2000. <www.sciencedaily.com/releases/2000/09/000921071625.htm>.
Dana-Farber Cancer Institute. (2000, September 25). Combinaton Of Radiation And Hormone Suppression Therapy Shown To Effectively Treat Early-Stage Prostate Cancer. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2000/09/000921071625.htm
Dana-Farber Cancer Institute. "Combinaton Of Radiation And Hormone Suppression Therapy Shown To Effectively Treat Early-Stage Prostate Cancer." ScienceDaily. www.sciencedaily.com/releases/2000/09/000921071625.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins