Featured Research

from universities, journals, and other organizations

Combinaton Of Radiation And Hormone Suppression Therapy Shown To Effectively Treat Early-Stage Prostate Cancer

Date:
September 25, 2000
Source:
Dana-Farber Cancer Institute
Summary:
In the first study of its kind, researchers at Brigham and Women's Hospital (BWH) and Dana-Farber Cancer Institute (DFCI) have found that combined radiation therapy (RT) and androgen suppression therapy (AST) is a more effective treatment for localized, early-stage prostate cancer compared to treatment using radiation therapy alone.

Results similar to success in treating advanced-stage cancers

Related Articles


BOSTON -- In the first study of its kind, researchers at Brigham and Women's Hospital (BWH) and Dana-Farber Cancer Institute (DFCI) have found that combined radiation therapy (RT) and androgen suppression therapy (AST) is a more effective treatment for localized, early-stage prostate cancer compared to treatment using radiation therapy alone. The findings are published in the September 13th issue of JAMA (Journal of the American Medical Association).

"Previous studies have shown a benefit to treating advanced-stage prostate cancer with radiation and hormone therapy," said Anthony V. D'Amico, MD, PhD, of BWH and DFCI. "This is the first study to show that the combination treatment may also benefit people with early-stage cancer."

Prostate cancer is the second leading cause of cancer death among men in this country. The American Cancer Society estimates that about 184,500 American men will be diagnosed with the disease this year and 39,200 will die.

In the study, researchers compared the relative risk of prostate specific antigen (PSA) failure during a five-year period in men who underwent RT and AST as treatment for diagnosed early-stage prostate cancer compared with men who received RT.

Although no significant difference between treatment groups was found in patients in the low-risk category, men who were classified in the intermediate-risk group and received both therapies for their cancer were five times less likely to have PSA failure than men who received RT alone. For men in the high-risk group who received both RT and AST, the effectiveness of combination therapy was more profound; they were two and one-half times less likely to have PSA failure than men who had received RT. "While further research is needed, it appears that the one-two punch of RT and AST may be a more effective treatment in the battle against both advanced-stage and early-stage prostate cancer," added Dr. D'Amico.

The 1,586 study participants were categorized using a combination of their PSA levels, biopsy Gleason score, and stage of tumor into three groups. All patients in the study had cancer that was localized to the prostate by rectal exam. The more aggressive the participant's tumor, the higher the risk category in which he was placed. The men's cancers were treated using a three-dimensional conformal RT with or without AST.

AST is a type of hormonal therapy that is often used in all phases of prostate cancer treatment to help block production or action of the male hormones that have been shown to fuel prostate cancer.


Story Source:

The above story is based on materials provided by Dana-Farber Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Dana-Farber Cancer Institute. "Combinaton Of Radiation And Hormone Suppression Therapy Shown To Effectively Treat Early-Stage Prostate Cancer." ScienceDaily. ScienceDaily, 25 September 2000. <www.sciencedaily.com/releases/2000/09/000921071625.htm>.
Dana-Farber Cancer Institute. (2000, September 25). Combinaton Of Radiation And Hormone Suppression Therapy Shown To Effectively Treat Early-Stage Prostate Cancer. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2000/09/000921071625.htm
Dana-Farber Cancer Institute. "Combinaton Of Radiation And Hormone Suppression Therapy Shown To Effectively Treat Early-Stage Prostate Cancer." ScienceDaily. www.sciencedaily.com/releases/2000/09/000921071625.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins