Featured Research

from universities, journals, and other organizations

Major Review Reveals That Osteoarthritis Is A Complex Disease With New Solutions

Date:
January 8, 2001
Source:
National Institute Of Arthritis And Musculoskeletal And Skin Diseases
Summary:
A multidisciplinary group of scientists has declared that osteoarthritis (OA), the most common form of arthritis, is "surprisingly complex," but has outlined a number of new approaches to its understanding, prevention and treatment.

A multidisciplinary group of scientists has declared that osteoarthritis (OA), the most common form of arthritis, is "surprisingly complex," but has outlined a number of new approaches to its understanding, prevention and treatment. Their report, a review by 28 researchers at 17 academic and government institutions, cites over 250 published articles and is presented in two parts in the Annals of Internal Medicine. The effort was led by David T. Felson, M.D., M.P.H., of Boston University, and Reva C. Lawrence, M.P.H., of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), a part of the National Institutes of Health (NIH).

The disease, says the review, can result from an inherited predisposition to OA combined with a joint injury. Regular runners have almost no additional risk of OA, but football and soccer players and baseball pitchers are at increased risk. A healthy lifestyle helps — exercise can lessen disability if OA has developed. Strengthening the thigh muscles reduces risk of OA of the knee, as can losing weight. For people who have the disease, a combination of treatment approaches, including new medications and patient education, is effective.

"I am delighted that we have been able to publish this comprehensive, two-part review arising from our 1999 conference 'Stepping Away from OA,' " says Stephen I. Katz, M.D., Ph.D., director of the NIAMS. "OA is a major public health problem, affecting some 20 million people in this country."

The review points out that in the United States about 6 percent of adults over 30 have OA of the knee and about 3 percent have OA of the hip. The disease is responsible for more trouble walking and stair climbing than any other disease, and it is the most common indication for total joint replacement of the hip and knee. Before age 50 the prevalence of OA in most joints is higher in men than women. After this age, more women are affected by OA of the hand, foot and knee. The occurrence of the disease increases with age, rising 2- to 10-fold in people from 30 to 65 years of age.

In osteoarthritis, there is focused, progressive loss of cartilage, the slippery material that cushions the ends of bones, along with changes in the bone below the cartilage leading to bony overgrowth. The tissue lining of the joint can become inflamed, the ligaments looser, and associated muscles weak, with resulting pain when the joint is used.

The review covers risk factors, such as being overweight and joint injury from specific sports, and treatments ranging from established and new medications, exercise, and patient education to surgery when other treatments do not work. It also discusses new areas of research, such as easily measured disease indicators known as biomarkers, as well as engineering of new cartilage. Specific findings are given on the attached backgrounder.

"This review shows that arthritis research is a vibrant area, yielding new means of preventing the disease and slowing its progression, as well as new and effective combinations of drug and behavioral treatments," says Dr. Katz, NIAMS director. "People with osteoarthritis and those at risk for the disease should be encouraged that there is much that they and their doctors can do about it."


Story Source:

The above story is based on materials provided by National Institute Of Arthritis And Musculoskeletal And Skin Diseases. Note: Materials may be edited for content and length.


Cite This Page:

National Institute Of Arthritis And Musculoskeletal And Skin Diseases. "Major Review Reveals That Osteoarthritis Is A Complex Disease With New Solutions." ScienceDaily. ScienceDaily, 8 January 2001. <www.sciencedaily.com/releases/2001/01/010108072611.htm>.
National Institute Of Arthritis And Musculoskeletal And Skin Diseases. (2001, January 8). Major Review Reveals That Osteoarthritis Is A Complex Disease With New Solutions. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2001/01/010108072611.htm
National Institute Of Arthritis And Musculoskeletal And Skin Diseases. "Major Review Reveals That Osteoarthritis Is A Complex Disease With New Solutions." ScienceDaily. www.sciencedaily.com/releases/2001/01/010108072611.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins