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New Clue To Diagnosis And Treatment Of Malignant Melanoma

Date:
January 15, 2001
Source:
Cold Spring Harbor Laboratory
Summary:
Malignant melanoma is an aggressive, deadly cancer that does not respond to conventional chemotherapy. Other aggressive, chemoresistant cancers — and approximately half of all cancers — are characterized by mutations in the p53 tumor suppressor gene. Malignant melanomas, however, do not typically display mutations in the p53 gene. To explore alternative explanations for the origins and properties of malignant melanoma, and to identify potential targets and strategies for therapy, Scott Lowe and his colleagues at Cold Spring Harbor Laboratory have examined the status of other genes known to function downstream of p53 in a pathway leading to "apoptosis" or "programmed cell death."

Cold Spring Harbor, NY -- Malignant melanoma is an aggressive, deadly cancer that does not respond to conventional chemotherapy. Other aggressive, chemoresistant cancers — and approximately half of all cancers — are characterized by mutations in the p53 tumor suppressor gene. Malignant melanomas, however, do not typically display mutations in the p53 gene.


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The above story is based on materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.


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Cold Spring Harbor Laboratory. "New Clue To Diagnosis And Treatment Of Malignant Melanoma." ScienceDaily. ScienceDaily, 15 January 2001. <www.sciencedaily.com/releases/2001/01/010111075020.htm>.
Cold Spring Harbor Laboratory. (2001, January 15). New Clue To Diagnosis And Treatment Of Malignant Melanoma. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2001/01/010111075020.htm
Cold Spring Harbor Laboratory. "New Clue To Diagnosis And Treatment Of Malignant Melanoma." ScienceDaily. www.sciencedaily.com/releases/2001/01/010111075020.htm (accessed April 24, 2014).

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