Featured Research

from universities, journals, and other organizations

Georgetown University Researchers Discover New Paradigm In Cellular Communication

Date:
March 5, 2001
Source:
Georgetown University Medical Center
Summary:
New discoveries about the way in which cellular receptors communicate with each other have helped scientists gain deeper insights into how new blood vessels develop—which could, down the road, lead to new ways of treating cancer and heart disease, researchers at Georgetown University Medical Center said.

New discoveries about the way in which cellular receptors communicate with each other have helped scientists gain deeper insights into how new blood vessels develop—which could, down the road, lead to new ways of treating cancer and heart disease, researchers at Georgetown University Medical Center said. Their findings are published in the March 2 issue of the journal Science.

Related Articles


The Georgetown researchers collaborated with colleagues at Howard Hughes Medical Institute Laboratories, Duke University Medical Center, and the National Institute of Mental Health on a study of the ability of cells to move toward a stimulus that is important in blood vessel development.

The researchers discovered that the cellular receptor of the important mediator sphingosine-1-phosphate, known as EDG-1, controls the ability of blood vessel supporting cells to move toward a signaling growth factor important for proper blood vessel development. They also found that the enzyme responsible for production of sphingosine-1-phosphate, called sphingosine kinase—which was first cloned and characterized in the lead author’s laboratory at Georgetown—plays a critical role in this process.

“Our work has revealed a completely new paradigm for communication between two different cellular receptors that is critical for cell motility,” said Sarah Spiegel, PhD, the lead investigator for this study and professor of biochemistry and molecular biology at Georgetown. “It has profound implications for normal maturation of blood vessels during development and for the formation of new blood vessels.”

Georgetown University Medical Center is one of the nation’s preeminent institutions of medical research and education. It includes a biomedical research enterprise, and the nationally ranked School of Medicine and School of Nursing and Health Studies.


Story Source:

The above story is based on materials provided by Georgetown University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Georgetown University Medical Center. "Georgetown University Researchers Discover New Paradigm In Cellular Communication." ScienceDaily. ScienceDaily, 5 March 2001. <www.sciencedaily.com/releases/2001/03/010305071801.htm>.
Georgetown University Medical Center. (2001, March 5). Georgetown University Researchers Discover New Paradigm In Cellular Communication. ScienceDaily. Retrieved January 28, 2015 from www.sciencedaily.com/releases/2001/03/010305071801.htm
Georgetown University Medical Center. "Georgetown University Researchers Discover New Paradigm In Cellular Communication." ScienceDaily. www.sciencedaily.com/releases/2001/03/010305071801.htm (accessed January 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, January 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Poultry Culled in Taiwan to Thwart Bird Flu

Poultry Culled in Taiwan to Thwart Bird Flu

Reuters - News Video Online (Jan. 28, 2015) Taiwan culls over a million poultry in efforts to halt various strains of avian flu. Julie Noce reports. Video provided by Reuters
Powered by NewsLook.com
Media Criticizing Parents For Not Vaccinating Children

Media Criticizing Parents For Not Vaccinating Children

Newsy (Jan. 28, 2015) As the Disneyland measles outbreak continues to spread, the media says parents who choose not to vaccinate their children are part of the cause. Video provided by Newsy
Powered by NewsLook.com
Shark Bite Victim Making Amazing Recovery

Shark Bite Victim Making Amazing Recovery

AP (Jan. 27, 2015) A Texas woman who lost more than five pounds of flesh to a shark in the Bahamas earlier this month could be released from a Florida hospital soon. Experts believe she was bitten by a bull shark while snorkeling. (Jan. 27) Video provided by AP
Powered by NewsLook.com
Shoveling Snow: How to Prevent Back Injuries

Shoveling Snow: How to Prevent Back Injuries

Washington Post (Jan. 26, 2015) What&apos;s the proper technique for shoveling snow? A physical therapist offers specific tips for protecting your back while you dig out this winter. Video provided by Washington Post
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins