Featured Research

from universities, journals, and other organizations

Georgetown University Researchers Discover New Paradigm In Cellular Communication

Date:
March 5, 2001
Source:
Georgetown University Medical Center
Summary:
New discoveries about the way in which cellular receptors communicate with each other have helped scientists gain deeper insights into how new blood vessels develop—which could, down the road, lead to new ways of treating cancer and heart disease, researchers at Georgetown University Medical Center said.

New discoveries about the way in which cellular receptors communicate with each other have helped scientists gain deeper insights into how new blood vessels develop—which could, down the road, lead to new ways of treating cancer and heart disease, researchers at Georgetown University Medical Center said. Their findings are published in the March 2 issue of the journal Science.

The Georgetown researchers collaborated with colleagues at Howard Hughes Medical Institute Laboratories, Duke University Medical Center, and the National Institute of Mental Health on a study of the ability of cells to move toward a stimulus that is important in blood vessel development.

The researchers discovered that the cellular receptor of the important mediator sphingosine-1-phosphate, known as EDG-1, controls the ability of blood vessel supporting cells to move toward a signaling growth factor important for proper blood vessel development. They also found that the enzyme responsible for production of sphingosine-1-phosphate, called sphingosine kinase—which was first cloned and characterized in the lead author’s laboratory at Georgetown—plays a critical role in this process.

“Our work has revealed a completely new paradigm for communication between two different cellular receptors that is critical for cell motility,” said Sarah Spiegel, PhD, the lead investigator for this study and professor of biochemistry and molecular biology at Georgetown. “It has profound implications for normal maturation of blood vessels during development and for the formation of new blood vessels.”

Georgetown University Medical Center is one of the nation’s preeminent institutions of medical research and education. It includes a biomedical research enterprise, and the nationally ranked School of Medicine and School of Nursing and Health Studies.


Story Source:

The above story is based on materials provided by Georgetown University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Georgetown University Medical Center. "Georgetown University Researchers Discover New Paradigm In Cellular Communication." ScienceDaily. ScienceDaily, 5 March 2001. <www.sciencedaily.com/releases/2001/03/010305071801.htm>.
Georgetown University Medical Center. (2001, March 5). Georgetown University Researchers Discover New Paradigm In Cellular Communication. ScienceDaily. Retrieved August 23, 2014 from www.sciencedaily.com/releases/2001/03/010305071801.htm
Georgetown University Medical Center. "Georgetown University Researchers Discover New Paradigm In Cellular Communication." ScienceDaily. www.sciencedaily.com/releases/2001/03/010305071801.htm (accessed August 23, 2014).

Share This




More Health & Medicine News

Saturday, August 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins