Featured Research

from universities, journals, and other organizations

DDT, PCBs Not Linked To Higher Rates Of Breast Cancer, An Analysis Of Five Northeast Studies Concludes

Date:
May 21, 2001
Source:
NIH/National Institute Of Environmental Health Sciences
Summary:
Scientists who combined data from five large breast cancer studies have found no link to the pesticide DDT or to PCBs, a widespread industrial chemical. Both were suspect because they are chemicals in the environment with similarities to estrogen, the so-called female hormone associated with a risk of breast cancer.

Scientists who combined data from five large breast cancer studies have found no link to the pesticide DDT or to PCBs, a widespread industrial chemical.

Both were suspect because they are chemicals in the environment with similarities to estrogen, the so-called female hormone associated with a risk of breast cancer.

The five studies were funded in 1993 by the National Cancer Institute and the National Institute of Environmental Health Sciences among women in the northeastern United States. None had shown a link between either DDT or PCBs and the Northeast's elevated rates of breast cancer. But some scientists thought the studies might simply have been too small and that their combined data might reveal such associations, at least for some subgroups of women.

Today that explanation was dashed as scientists analyzing the combined data also concluded that neither exposure explains the high rates of breast cancer in the U.S. Northeast. Their results appear in the May 16 issue of the Journal of the National Cancer Institute.

The women in the five studies totaled 1,400 breast cancer patients and 1,642 controls. Two of the studies were conducted among women in New York state, one was in Connecticut, and one was in Maryland. Half the women in the fifth study, the nationwide Nurses Health Study, live in the northeastern states, including Maryland.

In each of the studies, blood was drawn from patients and controls alike and tested for DDE, the major break-down product of DDT, and for PCBs. DDT and PCBs were widely used in the United States until the 1970s and accumulate in the body's fatty tissues and thus can be found in human blood and breast milk many years after exposures.

The principal author of the analysis, Francine Laden, Sc.D of Brigham and Women's Hospital, Boston, said, "We found that the combined results from these five studies do not support an association between plasma or serum concentrations of DDE and PCBs and an increased risk of breast cancer."

The second author, Gwen Collman, Ph.D., of the National Institute of Environmental Health Sciences, said, "The investigators used a standardized approach to data analysis across all five studies and we did not find a consistent association in the various subgroups we looked at: Caucasian women, African-American women, women of various body mass and lactation histories."

Brigham and Women's Hospital is a 716-bed affiliate of Harvard Medical School. The National Institute of Environmental Health Sciences, while headquartered in Research Triangle Park, N.C., is a part of the National Institutes of Health, as is the National Cancer Institute. NIH and NCI have their headquarters in Bethesda, Md.


Story Source:

The above story is based on materials provided by NIH/National Institute Of Environmental Health Sciences. Note: Materials may be edited for content and length.


Cite This Page:

NIH/National Institute Of Environmental Health Sciences. "DDT, PCBs Not Linked To Higher Rates Of Breast Cancer, An Analysis Of Five Northeast Studies Concludes." ScienceDaily. ScienceDaily, 21 May 2001. <www.sciencedaily.com/releases/2001/05/010521071722.htm>.
NIH/National Institute Of Environmental Health Sciences. (2001, May 21). DDT, PCBs Not Linked To Higher Rates Of Breast Cancer, An Analysis Of Five Northeast Studies Concludes. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2001/05/010521071722.htm
NIH/National Institute Of Environmental Health Sciences. "DDT, PCBs Not Linked To Higher Rates Of Breast Cancer, An Analysis Of Five Northeast Studies Concludes." ScienceDaily. www.sciencedaily.com/releases/2001/05/010521071722.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins