Featured Research

from universities, journals, and other organizations

Stem Cells Help Regenerate Tissue Damaged From Heart Attack

Date:
June 1, 2001
Source:
Baylor College Of Medicine
Summary:
Stem cells from bone marrow might one day mend damaged hearts, according to research conducted at Baylor College of Medicine.

HOUSTON--(May 29, 2001) -- Stem cells from bone marrow might one day mend damaged hearts, according to research conducted at Baylor College of Medicine.

The work, led by Drs. Margaret Goodell and Karen Hirschi, is the latest in the fast-moving field of stem cell research, which focuses on the ever-versatile cells that can transform themselves into various tissues. Study results are published in the June 1 issue of The Journal of Clinical Investigation.

Goodell, Hirschi and their research team found that stem cells taken from the bone marrow of an adult mouse and transplanted into the bone marrow of another adult mouse had the capability to transform into blood vessels and cardiac muscle, contributing to the restoration of tissue that had been damaged from a heart attack.

"The body's natural response to injury is to repair itself," Goodell said. "By letting the cells move into the blood stream, we've shown that the transformation of the bone marrow stem cells into blood vessels and heart tissue is part of a naturally occurring process."

The natural repair process, however, is overwhelmed after severe injuries, like those caused by a heart attack, and is not sufficient to completely restore the heart tissue. The scientists are working to enhance that process.

For the research, Goodell and Hirschi, assistant professors in the Center for Cell and Gene Therapy and the department of pediatrics at Baylor, and their team extracted stem cells from the bone marrow of the mouse. The cells were "purified," using a cell sorter, and a technique designed by Goodell to isolate certain types of stem cells one by one.

Those cells were tagged with a blue marker so they could be easily identified and transplanted into the bone marrow of another mouse.

To induce a non-fatal heart attack, Dr. Mark Entman, a professor of medicine at Baylor and scientific director of The DeBakey Heart Center at Baylor and The Methodist Hospital, created a blockage by temporarily tying off the coronary artery of the mouse with the new stem cells.

The researchers then waited two weeks for the tissue to repair. Upon examining the heart, they found marked stem cells in both the blood vessels and cardiac muscle. Marked stem cells were not found in the hearts of healthy mice with normal hearts, even though they had been injected with the marked stem cells as well.

""We believe that the cells can contribute to the regeneration of tissue, but are not sufficient to fully repair a heart at this point. If we can improve upon this process, it could be a promising addition to current therapy," Goodell said.

This approach distinguishes these findings from similar studies. Use of the blood stream eliminates the risks of open-heart surgery, which is necessary to inject stem cells directly into the heart, and infections.

More than a million Americans suffer heart attacks each year. Although medications can minimize damage, they don't repair the dead tissue and prevent complications that often arise such as scarring that can cripple the heart.

"Ultimately, we want to develop targeted therapy, taking the patient's own stem cells to repair damaged tissue, preventing rejection. But first, we need to understand the mechanism –- how stem cells turn into heart or vessel cells -- and improve on that to make it more efficient. We want to direct that development," Goodell said.

Study co-authors were Kathyjo A. Jackson, Susan M. Majka, Hongyu Wang, Jennifer Pocius, Craig J. Hartley, Mark W. Majesky, Mark L. Entman, and Lloyd H. Michael.


Story Source:

The above story is based on materials provided by Baylor College Of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Baylor College Of Medicine. "Stem Cells Help Regenerate Tissue Damaged From Heart Attack." ScienceDaily. ScienceDaily, 1 June 2001. <www.sciencedaily.com/releases/2001/06/010601082914.htm>.
Baylor College Of Medicine. (2001, June 1). Stem Cells Help Regenerate Tissue Damaged From Heart Attack. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2001/06/010601082914.htm
Baylor College Of Medicine. "Stem Cells Help Regenerate Tissue Damaged From Heart Attack." ScienceDaily. www.sciencedaily.com/releases/2001/06/010601082914.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Cases Keep Coming for Monrovia's Island Hospital

Ebola Cases Keep Coming for Monrovia's Island Hospital

AFP (Oct. 1, 2014) A look inside Monrovia's Island Hospital, a key treatment centre in the fight against Ebola in Liberia's capital city. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Ebola Puts Stress on Liberian Health Workers

Ebola Puts Stress on Liberian Health Workers

AP (Oct. 1, 2014) The Ebola outbreak is putting stress on first responders in Liberia. Ambulance drivers say they are struggling with chronic shortages of safety equipment and patients who don't want to go to the hospital. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Newsy (Sep. 30, 2014) After the announcement that the first U.S. patient had been diagnosed with Ebola, doctors were quick to say a U.S. outbreak is highly unlikely. Video provided by Newsy
Powered by NewsLook.com
TX Hospital Confirms Patient Admitted With Ebola

TX Hospital Confirms Patient Admitted With Ebola

AP (Sep. 30, 2014) Medical officials from Texas Health Presbyterian Hospital confirm they are treating a patient with the Ebola virus, the first case found in the US. (Sept. 30 Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins