Featured Research

from universities, journals, and other organizations

University Of Pittsburgh Researchers Use Stem Cells To Treat Incontinence In Animal Models

Date:
June 11, 2001
Source:
University Of Pittsburgh Medical Center
Summary:
University of Pittsburgh researchers have successfully used stem cell tissue engineering to restore deficient urethral sphincter muscles in animal models, according to a study presented today at the 96th Annual Meeting of the American Urological Association (AUA). Researchers successfully regenerated viable muscle using muscle derived stem cells (MDSC).

ANAHEIM, Calif., June 5 – University of Pittsburgh researchers have successfully used stem cell tissue engineering to restore deficient urethral sphincter muscles in animal models, according to a study presented today at the 96th Annual Meeting of the American Urological Association (AUA). Researchers successfully regenerated viable muscle using muscle derived stem cells (MDSC). Results are published in abstract 1033 in the AUA proceedings.

Related Articles


“These findings are exciting on many levels. First, this is the first time that stem cell tissue engineering has been used to regenerate and restore function in deficient sphincter muscles. Secondly, it lays the foundation for further investigation into methods of using stem cells to treat stress urinary incontinence,” said Michael Chancellor, M.D., professor of urology and gynecology at the University of Pittsburgh School of Medicine.

In the study, researchers isolated MDSC from normal rats, transduced them with a reporter gene and injected the stem cells into allogenic denervated proximal urethral sphincters. After two weeks, they compared urethral muscle strips from normal, denervated and denervated-MDSC injected rats. Fast twitch muscle contractions were recorded after electrical field stimulation. The amplitude of fast twitch muscle contractions decreased in denervated sphincter muscles and improved in denervated sphincters injected with MDSC by approximately 88 percent.

In addition, histological evaluation revealed the formation of new skeletal muscle fiber at the urethral sphincter injection sites in the MDSC rats. “These results give us hope that we can find a permanent solution to stress urinary incontinence, a problem affecting a large number of Americans, ” says Steven Chung, M.D., University of Pittsburgh Medical Center, department of urology, who will present the results today.

Given the proper stimulus, stem cells have the ability to divide for indefinite periods and differentiate into a variety of different cells, including muscle. Researchers have been using this information to investigate the theory that it is possible to regenerate injured tissue through the injection of stem cells.

Urinary incontinence affects 13 million Americans. Those with stress urinary incontinence involuntarily lose urine while doing activities that put stress on the abdomen, such as laughing, sneezing, coughing, lifting or walking. A result of damage to the urethral sphincter, stress incontinence is most often caused by childbirth, menopause or pelvic surgery.


Story Source:

The above story is based on materials provided by University Of Pittsburgh Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Pittsburgh Medical Center. "University Of Pittsburgh Researchers Use Stem Cells To Treat Incontinence In Animal Models." ScienceDaily. ScienceDaily, 11 June 2001. <www.sciencedaily.com/releases/2001/06/010606073057.htm>.
University Of Pittsburgh Medical Center. (2001, June 11). University Of Pittsburgh Researchers Use Stem Cells To Treat Incontinence In Animal Models. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2001/06/010606073057.htm
University Of Pittsburgh Medical Center. "University Of Pittsburgh Researchers Use Stem Cells To Treat Incontinence In Animal Models." ScienceDaily. www.sciencedaily.com/releases/2001/06/010606073057.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
What's Different About This Latest Ebola Vaccine

What's Different About This Latest Ebola Vaccine

Newsy (Mar. 26, 2015) — A whole virus Ebola vaccine has been shown to protect monkeys exposed to the virus. Here&apos;s what&apos;s different about this vaccine. Video provided by Newsy
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) — Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins