Featured Research

from universities, journals, and other organizations

Wake Forest University Baptist Medical Center Participates In Largest-Ever Prostate Cancer Prevention Trial

Date:
July 24, 2001
Source:
Wake Forest University Baptist Medical Center
Summary:
Wake Forest University Baptist Medical Center has begun enrolling healthy men age 55 and older in the largest-ever prostate cancer prevention study, to determine if selenium and vitamin E prevent prostate cancer.

WINSTON-SALEM, N.C. (July 23, 2001) -- Wake Forest University Baptist Medical Center today begins enrolling healthy men age 55 and older in the largest-ever prostate cancer prevention study, to determine if selenium and vitamin E prevent prostate cancer.

Launched by the National Cancer Institute (NCI) and a network of researchers known as the Southwest Oncology Group, the Selenium and Vitamin E Cancer Prevention Trial (SELECT) will determine if these two dietary supplements can protect against prostate cancer, the second most common form of cancer in men.

SELECT is the first study to look specifically at the effects of vitamin E and selenium, both separately and together, in preventing prostate cancer. The study, involving 400 sites in the United States, Puerto Rico and Canada, will include a total of 32,400 men and will take up to 12 years to complete. Study investigators hope to recruit all study participants during the first five years of the trial, so that each man can be followed for at least seven years.

"This is an extremely important study," said Electra Paskett, Ph.D., program director of Cancer Control Research at the Comprehensive Cancer Center of Wake Forest University. "Previous research with vitamin E and selenium - in studies focused on other types of cancer - suggested that these nutrients might prevent prostate cancer. SELECT is focused on prostate cancer and, when the study is finished, we will know for sure whether these supplements can prevent the disease," she said.

"It is crucial that men of all races and ethnic backgrounds participate in SELECT," said Paskett. "And since African-American men have the highest incidence of prostate cancer in the world, we especially encourage them to consider joining this trial."

The disease also strikes black men at a younger age, so they will be eligible to enroll in the SELECT study at age 50, versus age 55 for other racial and ethnic groups. There is no upper age limit for participation in SELECT.

Selenium and vitamin E, both naturally occurring nutrients, are antioxidants. They are capable of neutralizing toxins known as "free radicals" that might otherwise damage the genetic material of cells and possibly lead to cancer. These nutrients were chosen for study because of the unexpected byproducts of two other large cancer prevention trials.

In a 1996 study of selenium to prevent nonmelanoma skin cancer, investigators found that while the supplement did not reduce skin cancer, it did decrease the incidence of prostate cancer in men by more than 60 percent.

Another trial, published in 1998, in which beta carotene and vitamin E were tested to prevent lung cancer, those who took vitamin E had 32 percent less prostate cancer. Neither beta carotene nor vitamin E was shown to prevent lung cancer.

Men in the SELECT study will visit their study site once every six months. Upon enrollment, they will be randomly assigned to one of four groups. One group will take 200 micrograms of selenium daily plus an inactive capsule, or placebo, that looks likes vitamin E. Another group will take 400 milligrams of vitamin E daily along with a placebo that looks like selenium. A third group will take both selenium and vitamin E. And a final group will be given two placebos.

Men may be able to participate in SELECT if they are age 55 or older (50 or older for African-American men); have never had prostate cancer and have not had any other cancer, except nonmelanoma skin cancer, in the last five years; and are generally in good health.

For more information on the SELECT study at Wake Forest University Baptist Medical Center, call Irma Richardson, study coordinator, at 336-716-7589 or 1-877-298-0110 option 4.


Story Source:

The above story is based on materials provided by Wake Forest University Baptist Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Wake Forest University Baptist Medical Center. "Wake Forest University Baptist Medical Center Participates In Largest-Ever Prostate Cancer Prevention Trial." ScienceDaily. ScienceDaily, 24 July 2001. <www.sciencedaily.com/releases/2001/07/010724081702.htm>.
Wake Forest University Baptist Medical Center. (2001, July 24). Wake Forest University Baptist Medical Center Participates In Largest-Ever Prostate Cancer Prevention Trial. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2001/07/010724081702.htm
Wake Forest University Baptist Medical Center. "Wake Forest University Baptist Medical Center Participates In Largest-Ever Prostate Cancer Prevention Trial." ScienceDaily. www.sciencedaily.com/releases/2001/07/010724081702.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Cases Keep Coming for Monrovia's Island Hospital

Ebola Cases Keep Coming for Monrovia's Island Hospital

AFP (Oct. 1, 2014) A look inside Monrovia's Island Hospital, a key treatment centre in the fight against Ebola in Liberia's capital city. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Ebola Puts Stress on Liberian Health Workers

Ebola Puts Stress on Liberian Health Workers

AP (Oct. 1, 2014) The Ebola outbreak is putting stress on first responders in Liberia. Ambulance drivers say they are struggling with chronic shortages of safety equipment and patients who don't want to go to the hospital. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Newsy (Sep. 30, 2014) After the announcement that the first U.S. patient had been diagnosed with Ebola, doctors were quick to say a U.S. outbreak is highly unlikely. Video provided by Newsy
Powered by NewsLook.com
TX Hospital Confirms Patient Admitted With Ebola

TX Hospital Confirms Patient Admitted With Ebola

AP (Sep. 30, 2014) Medical officials from Texas Health Presbyterian Hospital confirm they are treating a patient with the Ebola virus, the first case found in the US. (Sept. 30 Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins