Featured Research

from universities, journals, and other organizations

Estrogen, Soy Boost Recovery In Hearts After Surgery, Studies Show

Date:
August 3, 2001
Source:
University Of Illinois At Urbana-Champaign
Summary:
Extensive damage to cells, reduced nitric oxide production and too much calcium buildup. These negative consequences followed open-heart surgery in mice and rats in the absence of estrogen. With estrogen or a soy-based equivalent, post-operative damage is much less.

CHAMPAIGN, Ill. — Extensive damage to cells, reduced nitric oxide production and too much calcium buildup. These negative consequences followed open-heart surgery in mice and rats in the absence of estrogen. With estrogen or a soy-based equivalent, post-operative damage is much less.

Ongoing experiments at the University of Illinois on female and male rodents are shedding light on the role of estrogen during heart surgery. Specifically, researchers are examining the impacts of estrogen during ischemia, when arterial blood flow is stopped, and reperfusion, when the flow resumes.

The latest findings, to appear in the American Journal of Physiology: Heart and Circulatory Physiology, document how the estrogen-like components of soy provide the same protection as estrogen in female rats. In two studies published last year, estrogen’s role was shown in males and females. "Under controlled, well-defined circumstances, we’ve shown that without question estrogen, whether it is natural or from soy phytoestrogens, is offering protection," said David R. Gross, a professor of physiology and head of veterinary biosciences in the UI College of Veterinary Medicine. Regardless of the repairs made to the heart, reperfusion carries risks. The level of damage that naturally occurs can dictate how well a heart restarts and recovers, Gross said.

The research is part of a departmentwide effort to understand the molecular mechanisms of estrogen in different systems of the body. "If we are able to dissect the mechanisms of estrogen’s actions on the testes, for example, those same mechanisms will probably be functional in the heart," Gross said.

"Once we find the specific proteins that are involved in the hormone’s activities, then we can develop designer drugs," he said. "We’d like to able to block undesirable actions, such as those involved in breast cancer, or stimulate activity that may help the heart function better or heal faster."

Researchers examining the heart are using mice and rats that lack estrogen. In the new study, 10 estrogen-lacking female rats ate a diet of soy rich in the isoflavones genistein, daidzein and glycitein, which bind to estrogen receptors, for three months.

The animals then went to surgery. Blood flow and hearts were stopped for 30 minutes followed by reperfusion with a standard blood substitute (oxygenated Krebs-Henseleit bicarbonate buffer). The hearts were restarted and allowed to function for two hours. The non-soy animals suffered severe damage like that in the animals not given estrogen in the earlier studies. Soy-fed rats had healthier levels of coronary blood flow, less edema, near normal nitric oxide production and no abnormal calcium accumulations.

Co-authors with Gross were doctoral student Peiyong Zhai, now at Johns Hopkins Medical Center in Baltimore; and UI colleagues Elizabeth H. Jeffery, food science and human nutrition; Janice M. Bahr, animal sciences; and Thomas E. Eurell and Robert P. Cotthaus, veterinary biosciences. The Illinois Council for Food and Agricultural Research supported the soy-related work.


Story Source:

The above story is based on materials provided by University Of Illinois At Urbana-Champaign. Note: Materials may be edited for content and length.


Cite This Page:

University Of Illinois At Urbana-Champaign. "Estrogen, Soy Boost Recovery In Hearts After Surgery, Studies Show." ScienceDaily. ScienceDaily, 3 August 2001. <www.sciencedaily.com/releases/2001/08/010802080709.htm>.
University Of Illinois At Urbana-Champaign. (2001, August 3). Estrogen, Soy Boost Recovery In Hearts After Surgery, Studies Show. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2001/08/010802080709.htm
University Of Illinois At Urbana-Champaign. "Estrogen, Soy Boost Recovery In Hearts After Surgery, Studies Show." ScienceDaily. www.sciencedaily.com/releases/2001/08/010802080709.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins