Featured Research

from universities, journals, and other organizations

Structure Of Key Protein Involved In Cancer, Osteoporosis And Foot-And-Mouth Disease Finally Solved

Date:
September 10, 2001
Source:
Massachusetts General Hospital
Summary:
Researchers at Massachusetts General Hospital (MGH) have solved the structure of an integrin receptor, a key protein involved in diseases and processes ranging from tumor angiogenesis and breast cancer metastasis to osteoporosis, vascular restenosis and foot-and-mouth disease.

Researchers at Massachusetts General Hospital (MGH) have solved the structure of an integrin receptor, a key protein involved in diseases and processes ranging from tumor angiogenesis and breast cancer metastasis to osteoporosis, vascular restenosis and foot-and-mouth disease. The finding, which will appear in Science magazine, was published Sept. 6 on the Science Express website http://www.sciencexpress.org.

"Knowing the shape of this receptor will help us all develop strategies to target many of these diseases," says M. Amin Arnaout, MD, Director of the Structural Biology Program at MGH and Chief of the MGH Renal Unit. The other members of the MGH research team are Jian-Ping Xiong, PhD, Thilo Stehle, PhD, and David Scott, MD, PhD. The new information may be useful in designing novel anti-angiogenic, anti-inflammatory, anti-viral, and anti-osteoporosis drugs that target integrins.

The MGH team of researchers has been trying to decipher the three dimensional structure of this particular integrin receptor for several years. "This is the first look anyone has had at the whole structure of this class of receptors," says Arnaout.

Integrin receptors transmit chemical signals from a cell's surface into its interior, which regulate most cellular processes such as attachment, proliferation, differentiation, and survival. Integrin receptors also have a unique ability to undergo shape-shifting as they become activated in response to the specialized needs of cells. "Elucidating the basic shape of these receptors is therefore key to understanding their function," says Arnaout.

An activated integrin receptor is able to bind a molecule called a ligand, in a lock and key fashion. Integrin receptors are very promiscuous, though, and they fit a variety of ligand 'keys,' including viral proteins that hijack these receptors to gain entry into cells.

There are many different types of integrin receptors, all with similar structural motifs. Some of these play important roles in other diseases, such as stroke, heart attack, diabetes, and rheumatoid arthritis. "This work will help researchers who are working on other integrin receptors to develop new therapeutic applications based on this work," says Arnaout.

The MGH team of researchers worked in collaboration with Merck KGaA in Germany and the Argonne National Laboratory in Illinois. The study was supported by research grants from the National Institutes of Health to the MGH team.

The Massachusetts General Hospital, established in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH conducts the largest hospital-based research program in the United States, with an annual research budget of more than $300 million and major research centers in AIDS, the neurosciences, cardiovascular research, cancer, cutaneous biology, photo-medicine, transplantation biology. In 1994, the MGH joined with Brigham and Women's Hospital to form Partners HealthCare System, an integrated health care delivery system comprising the two academic medical centers, specialty and community hospitals, a network of physician groups and non acute and home health services.


Story Source:

The above story is based on materials provided by Massachusetts General Hospital. Note: Materials may be edited for content and length.


Cite This Page:

Massachusetts General Hospital. "Structure Of Key Protein Involved In Cancer, Osteoporosis And Foot-And-Mouth Disease Finally Solved." ScienceDaily. ScienceDaily, 10 September 2001. <www.sciencedaily.com/releases/2001/09/010907081921.htm>.
Massachusetts General Hospital. (2001, September 10). Structure Of Key Protein Involved In Cancer, Osteoporosis And Foot-And-Mouth Disease Finally Solved. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2001/09/010907081921.htm
Massachusetts General Hospital. "Structure Of Key Protein Involved In Cancer, Osteoporosis And Foot-And-Mouth Disease Finally Solved." ScienceDaily. www.sciencedaily.com/releases/2001/09/010907081921.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins