Featured Research

from universities, journals, and other organizations

Alzheimer's And Parkinson's Proteins Create A Destructive Team

Date:
September 26, 2001
Source:
University Of California - San Diego
Summary:
The proteins associated with Alzheimer’s disease and Parkinson’s disease interact to enhance each other’s distinct degenerative effects, indicating that therapies blocking the production or accumulation of either protein may have broader benefits than previously thought, researchers report in the September 25 Proceedings of the National Academy of Sciences.

The proteins associated with Alzheimer’s disease and Parkinson’s disease interact to enhance each other’s distinct degenerative effects, indicating that therapies blocking the production or accumulation of either protein may have broader benefits than previously thought, researchers report in the September 25 Proceedings of the National Academy of Sciences, published electronically.

Alzheimer’s disease and Parkinson’s disease are distinct neurological disorders, but up to one-third of Alzheimer’s patient develop Parkinson’s, and some Parkinson’s patient develop signs of Alzheimer’s.

To explore possible connections between the two diseases, scientists from UCSD’s departments of neurosciences and pathology, and from the Gladstone Institute of Neurological Diseases and the UCSF department of neurology, developed strains of transgenic mice that produce two human proteins, human amyloid precursor protein (hAPP) and human alpha-synuclein (hSYN), which are known to accumulate in Alzheimer’s and Parkinson’s, respectively.

Mice that produced one of the proteins developed the symptoms of the respective disease. But when both proteins were produced in the same mouse, the Alzheimer’s-like symptoms of the hAPP mice—degeneration of particular classes of brain cells, impaired ablity to learn—were exacerbated by the production of hSYN. The Parkinson-like motor deficits of the hSYN mice developed sooner in the mice that also expressed hAPP.

In addition, a metabolic breakdown product of hAPP, called Abeta, enhanced the accumulation of hSYN in brain cells, indicating a possible mechanism for the synergistic effects that were observed. Results of the study also clarify the underlying mechanisms that destroy the cognitive and motor functions of Alzheimer’s patients who also develop Parkinson’s.

Because these proteins interact to accelerate and exacerbate the symptoms of their respective diseases, drugs aimed at preventing the accumulation of hAPP or hSYN could benefit a wider spectrum of neurodegenerative disorders than previously thought, the scientists speculate.

This work was conducted by Eliezer Masliah of UCSD, Lennart Mucke of the Gladstone Institute of Neurological Disease at UCSF, and Edward Rockenstein, Isaac Veinbergs, Yutaka Sagara, Margaret Mallory and Makoto Hashimoto of UCSD. The research was supported by the National Institutes of Health.


Story Source:

The above story is based on materials provided by University Of California - San Diego. Note: Materials may be edited for content and length.


Cite This Page:

University Of California - San Diego. "Alzheimer's And Parkinson's Proteins Create A Destructive Team." ScienceDaily. ScienceDaily, 26 September 2001. <www.sciencedaily.com/releases/2001/09/010926071037.htm>.
University Of California - San Diego. (2001, September 26). Alzheimer's And Parkinson's Proteins Create A Destructive Team. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2001/09/010926071037.htm
University Of California - San Diego. "Alzheimer's And Parkinson's Proteins Create A Destructive Team." ScienceDaily. www.sciencedaily.com/releases/2001/09/010926071037.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins