Featured Research

from universities, journals, and other organizations

Alzheimer's And Parkinson's Proteins Create A Destructive Team

Date:
September 26, 2001
Source:
University Of California - San Diego
Summary:
The proteins associated with Alzheimer’s disease and Parkinson’s disease interact to enhance each other’s distinct degenerative effects, indicating that therapies blocking the production or accumulation of either protein may have broader benefits than previously thought, researchers report in the September 25 Proceedings of the National Academy of Sciences.

The proteins associated with Alzheimer’s disease and Parkinson’s disease interact to enhance each other’s distinct degenerative effects, indicating that therapies blocking the production or accumulation of either protein may have broader benefits than previously thought, researchers report in the September 25 Proceedings of the National Academy of Sciences, published electronically.

Alzheimer’s disease and Parkinson’s disease are distinct neurological disorders, but up to one-third of Alzheimer’s patient develop Parkinson’s, and some Parkinson’s patient develop signs of Alzheimer’s.

To explore possible connections between the two diseases, scientists from UCSD’s departments of neurosciences and pathology, and from the Gladstone Institute of Neurological Diseases and the UCSF department of neurology, developed strains of transgenic mice that produce two human proteins, human amyloid precursor protein (hAPP) and human alpha-synuclein (hSYN), which are known to accumulate in Alzheimer’s and Parkinson’s, respectively.

Mice that produced one of the proteins developed the symptoms of the respective disease. But when both proteins were produced in the same mouse, the Alzheimer’s-like symptoms of the hAPP mice—degeneration of particular classes of brain cells, impaired ablity to learn—were exacerbated by the production of hSYN. The Parkinson-like motor deficits of the hSYN mice developed sooner in the mice that also expressed hAPP.

In addition, a metabolic breakdown product of hAPP, called Abeta, enhanced the accumulation of hSYN in brain cells, indicating a possible mechanism for the synergistic effects that were observed. Results of the study also clarify the underlying mechanisms that destroy the cognitive and motor functions of Alzheimer’s patients who also develop Parkinson’s.

Because these proteins interact to accelerate and exacerbate the symptoms of their respective diseases, drugs aimed at preventing the accumulation of hAPP or hSYN could benefit a wider spectrum of neurodegenerative disorders than previously thought, the scientists speculate.

This work was conducted by Eliezer Masliah of UCSD, Lennart Mucke of the Gladstone Institute of Neurological Disease at UCSF, and Edward Rockenstein, Isaac Veinbergs, Yutaka Sagara, Margaret Mallory and Makoto Hashimoto of UCSD. The research was supported by the National Institutes of Health.


Story Source:

The above story is based on materials provided by University Of California - San Diego. Note: Materials may be edited for content and length.


Cite This Page:

University Of California - San Diego. "Alzheimer's And Parkinson's Proteins Create A Destructive Team." ScienceDaily. ScienceDaily, 26 September 2001. <www.sciencedaily.com/releases/2001/09/010926071037.htm>.
University Of California - San Diego. (2001, September 26). Alzheimer's And Parkinson's Proteins Create A Destructive Team. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2001/09/010926071037.htm
University Of California - San Diego. "Alzheimer's And Parkinson's Proteins Create A Destructive Team." ScienceDaily. www.sciencedaily.com/releases/2001/09/010926071037.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins