Featured Research

from universities, journals, and other organizations

Alzheimer's And Parkinson's Proteins Create A Destructive Team

Date:
September 26, 2001
Source:
University Of California - San Diego
Summary:
The proteins associated with Alzheimer’s disease and Parkinson’s disease interact to enhance each other’s distinct degenerative effects, indicating that therapies blocking the production or accumulation of either protein may have broader benefits than previously thought, researchers report in the September 25 Proceedings of the National Academy of Sciences.

The proteins associated with Alzheimer’s disease and Parkinson’s disease interact to enhance each other’s distinct degenerative effects, indicating that therapies blocking the production or accumulation of either protein may have broader benefits than previously thought, researchers report in the September 25 Proceedings of the National Academy of Sciences, published electronically.

Related Articles


Alzheimer’s disease and Parkinson’s disease are distinct neurological disorders, but up to one-third of Alzheimer’s patient develop Parkinson’s, and some Parkinson’s patient develop signs of Alzheimer’s.

To explore possible connections between the two diseases, scientists from UCSD’s departments of neurosciences and pathology, and from the Gladstone Institute of Neurological Diseases and the UCSF department of neurology, developed strains of transgenic mice that produce two human proteins, human amyloid precursor protein (hAPP) and human alpha-synuclein (hSYN), which are known to accumulate in Alzheimer’s and Parkinson’s, respectively.

Mice that produced one of the proteins developed the symptoms of the respective disease. But when both proteins were produced in the same mouse, the Alzheimer’s-like symptoms of the hAPP mice—degeneration of particular classes of brain cells, impaired ablity to learn—were exacerbated by the production of hSYN. The Parkinson-like motor deficits of the hSYN mice developed sooner in the mice that also expressed hAPP.

In addition, a metabolic breakdown product of hAPP, called Abeta, enhanced the accumulation of hSYN in brain cells, indicating a possible mechanism for the synergistic effects that were observed. Results of the study also clarify the underlying mechanisms that destroy the cognitive and motor functions of Alzheimer’s patients who also develop Parkinson’s.

Because these proteins interact to accelerate and exacerbate the symptoms of their respective diseases, drugs aimed at preventing the accumulation of hAPP or hSYN could benefit a wider spectrum of neurodegenerative disorders than previously thought, the scientists speculate.

This work was conducted by Eliezer Masliah of UCSD, Lennart Mucke of the Gladstone Institute of Neurological Disease at UCSF, and Edward Rockenstein, Isaac Veinbergs, Yutaka Sagara, Margaret Mallory and Makoto Hashimoto of UCSD. The research was supported by the National Institutes of Health.


Story Source:

The above story is based on materials provided by University Of California - San Diego. Note: Materials may be edited for content and length.


Cite This Page:

University Of California - San Diego. "Alzheimer's And Parkinson's Proteins Create A Destructive Team." ScienceDaily. ScienceDaily, 26 September 2001. <www.sciencedaily.com/releases/2001/09/010926071037.htm>.
University Of California - San Diego. (2001, September 26). Alzheimer's And Parkinson's Proteins Create A Destructive Team. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2001/09/010926071037.htm
University Of California - San Diego. "Alzheimer's And Parkinson's Proteins Create A Destructive Team." ScienceDaily. www.sciencedaily.com/releases/2001/09/010926071037.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins