Featured Research

from universities, journals, and other organizations

Columbia Presbyterian Researchers Show Prostate Cancer Drug Significantly Arrests Tumor Growth With Minimal Side Effects

Date:
October 3, 2001
Source:
Columbia University College Of Physicians And Surgeons
Summary:
The results of a clinical study of the effects of Exisulind, a new drug that has been shown to slow tumor growth in men with advanced prostate cancer, are being published in the September issue of The Journal of Urology. The study is the first of its kind to show a significant effect of a new class of drugs that may stabilize progressive, recurrent disease in patients with advanced prostate cancer.

NEW YORK, NY, - The results of a clinical study of the effects of Exisulind, a new drug that has been shown to slow tumor growth in men with advanced prostate cancer, are being published in the September issue of The Journal of Urology. The study is the first of its kind to show a significant effect of a new class of drugs that may stabilize progressive, recurrent disease in patients with advanced prostate cancer.

"These results suggest that Exisulind may delay disease progression in men with recurrent prostate cancer," says Dr. Erik Goluboff, Assistant Professor of Urology at Columbia University College of Physicians & Surgeons, Director of Urology at The Allen Pavilion of NewYork-Presbyterian Hospital, and the principal investigator of the trial. "This will subsequently prolong the time period between post-surgical PSA rise and the need for androgen deprivation therapies."

Exisulind is from a new class of compounds called selective apoptotic anti-neoplastic drugs (SAANDs). SAANDs inhibit cyclic GMP phosphodiesterase and selectively induce apoptosis (programmed cell death) in abnormally growing pre-cancerous and cancerous cells. Because SAANDs do not induce apoptosis in normal cells, they do not produce most of the adverse reactions or serious side effects normally associated with chemotherapeutic agents used to treat cancer.

Other available therapies, such as drugs, hormones, or radiation, try to limit spread of the disease and increase survival time by shrinking or stabilizing tumors but can impair patient recovery with severe side effects. "For instance, hormonal therapy produces high response rates in metastatic prostate cancer, but patients develop resistance over time," says Dr. Goluboff. "The side effects of hormonal treatment can significantly impact the patient's quality of life. New treatment options that might delay the need for such side effect-prone therapies could provide great benefit in the management of prostate cancer."

Previous studies in mice showed that Exisulind inhibits the growth of prostate cancer by 80 percent to 90 percent. In a related study of patients, researchers found that the drug also causes regression in the growth of precancerous colonic polyps, a condition that often leads to colon cancer.

For 12 months, the trial followed 96 prostate cancer patients who already had their prostate glands removed. All had rising prostate-specific antigen (PSA) levels indicating recurrent disease. Half received Exisulind, and half were given a placebo. The researchers measured the drug's ability to slow or halt disease progression by following patients' PSA levels. High levels of PSA are associated with more aggressive disease.

Imaging tests were performed before and after the study. All of the men were classified into risk groups with no statistical difference in age, race, and weight. The study showed a significant decrease in the rate of rise in PSA in patients given Exisulind compared with placebo.

Almost 185,000 new cases of prostate cancer will be diagnosed in the United States this year. More than 39,000 men will die of the disease, making it the second leading cause of cancer death in men. Although prognosis is good when prostate cancer is detected early, advanced disease, while treatable, has no cure.

Dr. Goluboff cautions that more research needs to be conducted to determine long-term effects in these patients and in other groups of patients with prostate cancer.

The study was funded by Cell Pathways Inc., developer of the drug Exisulind. The company first announced the results of the trial in November 1999.


Story Source:

The above story is based on materials provided by Columbia University College Of Physicians And Surgeons. Note: Materials may be edited for content and length.


Cite This Page:

Columbia University College Of Physicians And Surgeons. "Columbia Presbyterian Researchers Show Prostate Cancer Drug Significantly Arrests Tumor Growth With Minimal Side Effects." ScienceDaily. ScienceDaily, 3 October 2001. <www.sciencedaily.com/releases/2001/10/011003064106.htm>.
Columbia University College Of Physicians And Surgeons. (2001, October 3). Columbia Presbyterian Researchers Show Prostate Cancer Drug Significantly Arrests Tumor Growth With Minimal Side Effects. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2001/10/011003064106.htm
Columbia University College Of Physicians And Surgeons. "Columbia Presbyterian Researchers Show Prostate Cancer Drug Significantly Arrests Tumor Growth With Minimal Side Effects." ScienceDaily. www.sciencedaily.com/releases/2001/10/011003064106.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Obama Orders Military Response to Ebola

Obama Orders Military Response to Ebola

AP (Sep. 16, 2014) Calling the Ebola outbreak in West Africa a potential threat to global security, President Barack Obama is ordering 3,000 U.S. military personnel to the stricken region amid worries that the outbreak is spiraling out of control. (Sept. 16) Video provided by AP
Powered by NewsLook.com
UN: 20,000 Could Be Infected With Ebola by Year End

UN: 20,000 Could Be Infected With Ebola by Year End

AFP (Sep. 16, 2014) Nearly $1.0 billion dollars is needed to fight the Ebola outbreak raging in west Africa, the United Nations say, warning that 20,000 could be infected by year end. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com
Obama: Ebola Outbreak Threat to Global Security

Obama: Ebola Outbreak Threat to Global Security

AP (Sep. 16, 2014) President Obama is ordering U.S. military personnel to West Africa to deal with the Ebola outbreak, which is he calls a potential threat to global security. (Sept. 16) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins