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Scientists Identify Cells Necessary For Tumor Angiogenesis

Date:
November 5, 2001
Source:
Memorial Sloan-Kettering Cancer Center
Summary:
The biology of tumor growth has been a mystery. While it has been known that tumors recruit cells to form new blood vessels - a process called angiogenesis - and that growth factors are necessary to promote this, the origin of the cells that form the early, new blood vessels has been poorly understood. Researchers at Memorial Sloan-Kettering Cancer Center and Weill Medical College of Cornell University have discovered that tumor angiogenesis occurs when precursor cells from the bone marrow are mobilized and recruited by VEGF (vascular endothelial growth factor) stem cells to the tumor blood vessels.

NEW YORK, October 31, 2001 - The biology of tumor growth has been a mystery. While it has been known that tumors recruit cells to form new blood vessels - a process called angiogenesis - and that growth factors are necessary to promote this, the origin of the cells that form the early, new blood vessels has been poorly understood. Researchers at Memorial Sloan-Kettering Cancer Center and Weill Medical College of Cornell University have discovered that tumor angiogenesis occurs when precursor cells from the bone marrow are mobilized and recruited by VEGF (vascular endothelial growth factor) stem cells to the tumor blood vessels. Their findings, published in the November issue of Nature Medicine, suggest new targets for cancer therapies and a possible blood test for cancer.


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The above story is based on materials provided by Memorial Sloan-Kettering Cancer Center. Note: Materials may be edited for content and length.


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Memorial Sloan-Kettering Cancer Center. "Scientists Identify Cells Necessary For Tumor Angiogenesis." ScienceDaily. ScienceDaily, 5 November 2001. <www.sciencedaily.com/releases/2001/11/011101061053.htm>.
Memorial Sloan-Kettering Cancer Center. (2001, November 5). Scientists Identify Cells Necessary For Tumor Angiogenesis. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2001/11/011101061053.htm
Memorial Sloan-Kettering Cancer Center. "Scientists Identify Cells Necessary For Tumor Angiogenesis." ScienceDaily. www.sciencedaily.com/releases/2001/11/011101061053.htm (accessed April 16, 2014).

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