Featured Research

from universities, journals, and other organizations

Estrogen Found In Soy Stimulates Human Breast-Cancer Cells In Mice

Date:
November 5, 2001
Source:
University Of Illinois At Urbana-Champaign
Summary:
The increasingly consumed isoflavone genistein – a plant estrogen linked to the health benefits of soy – has been shown in a series of University of Illinois studies to stimulate the growth of estrogen-dependent human breast-cancer cells implanted into laboratory mice.

CHAMPAIGN, Ill. — The increasingly consumed isoflavone genistein – a plant estrogen linked to the health benefits of soy – has been shown in a series of University of Illinois studies to stimulate the growth of estrogen-dependent human breast-cancer cells implanted into laboratory mice.

The findings of three studies, funded by the National Institutes of Health, are detailed in the Journal of Nutrition (November), Carcinogenesis (October) and Cancer Research (July).

The results demonstrate that genistein in various forms stimulates tumor growth. They also suggest that women with estrogen-dependent breast cancer or a predisposition to it may want to reduce their consumption of soy products with a high isoflavone content, said William G. Helferich, a UI professor of food science and human nutrition. Many soy isoflavone-containing products are marketed to women over age 50 for the relief of menopausal symptoms.

“Our pre-clinical laboratory animal data suggest that caution is warranted regarding the use of soy supplements high in isoflavones for women with breast cancer, particularly if they are menopausal,” said Helferich, who was the principal researcher on the papers.

For most people, soy is a healthy food and can be used as part of a healthy diet, he said. Isolated soy protein had been found in previous UI studies to effectively lower cholesterol. Studies elsewhere have shown potential relief of menopausal symptoms and protection against cancer.

In the Journal of Nutrition, Helferich and colleagues show that the estrogen-dependent tumors implanted into experimental mice models grow at a rate in proportion to the levels of genistein consumed. Researchers used athymic mice that lack the ability to reject human cancer cells. After inserting breast cancer cells, researchers were able to closely monitor the dietary estrogen to stimulate tumor growth.

Genistein at or above 250 parts per million, a dosage that produces blood levels similar to what is observed in women consuming soy diets, was enough to stimulate tumor growth.

In the paper in Carcinogenesis, the researchers compared the isoflavone in its two forms, as a glycoside (genistin, as it appears in plants) and aglucone (genistein). They found that both forms produced similar tumor growth rates, and that the conversion of genistin to genistein in the body begins with contact with saliva in the mouth.

In Cancer Research, Helferich compared soy protein isolates containing varying levels of isoflavones. The researchers found that estrogen-dependent tumor growth increased as the isoflavone content increased in the soy-containing diet.


Story Source:

The above story is based on materials provided by University Of Illinois At Urbana-Champaign. Note: Materials may be edited for content and length.


Cite This Page:

University Of Illinois At Urbana-Champaign. "Estrogen Found In Soy Stimulates Human Breast-Cancer Cells In Mice." ScienceDaily. ScienceDaily, 5 November 2001. <www.sciencedaily.com/releases/2001/11/011105073548.htm>.
University Of Illinois At Urbana-Champaign. (2001, November 5). Estrogen Found In Soy Stimulates Human Breast-Cancer Cells In Mice. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2001/11/011105073548.htm
University Of Illinois At Urbana-Champaign. "Estrogen Found In Soy Stimulates Human Breast-Cancer Cells In Mice." ScienceDaily. www.sciencedaily.com/releases/2001/11/011105073548.htm (accessed August 28, 2014).

Share This




More Health & Medicine News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mini Pacemaker Has No Wires

Mini Pacemaker Has No Wires

Ivanhoe (Aug. 27, 2014) Cardiac experts are testing a new experimental device designed to eliminate major surgery and still keep the heart on track. Video provided by Ivanhoe
Powered by NewsLook.com
After Cancer: Rebuilding Breasts With Fat

After Cancer: Rebuilding Breasts With Fat

Ivanhoe (Aug. 27, 2014) More than 269 million women are diagnosed with breast cancer each year. Many of them will need surgery and radiation, but there’s a new simple way to reconstruct tissue using a patient’s own fat. Video provided by Ivanhoe
Powered by NewsLook.com
Blood Clots in Kids

Blood Clots in Kids

Ivanhoe (Aug. 27, 2014) Every year, up to 200,000 Americans die from a blood clot that travels to their lungs. You’ve heard about clots in adults, but new research shows kids can get them too. Video provided by Ivanhoe
Powered by NewsLook.com
Radio Waves Knock out Knee Pain

Radio Waves Knock out Knee Pain

Ivanhoe (Aug. 27, 2014) Doctors have used radio frequency ablation or RFA to reduce neck and back pain for years. But now, that same technique is providing longer-term relief for patients with severe knee pain. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins