Featured Research

from universities, journals, and other organizations

Estrogen Found In Soy Stimulates Human Breast-Cancer Cells In Mice

Date:
November 5, 2001
Source:
University Of Illinois At Urbana-Champaign
Summary:
The increasingly consumed isoflavone genistein – a plant estrogen linked to the health benefits of soy – has been shown in a series of University of Illinois studies to stimulate the growth of estrogen-dependent human breast-cancer cells implanted into laboratory mice.

CHAMPAIGN, Ill. — The increasingly consumed isoflavone genistein – a plant estrogen linked to the health benefits of soy – has been shown in a series of University of Illinois studies to stimulate the growth of estrogen-dependent human breast-cancer cells implanted into laboratory mice.

Related Articles


The findings of three studies, funded by the National Institutes of Health, are detailed in the Journal of Nutrition (November), Carcinogenesis (October) and Cancer Research (July).

The results demonstrate that genistein in various forms stimulates tumor growth. They also suggest that women with estrogen-dependent breast cancer or a predisposition to it may want to reduce their consumption of soy products with a high isoflavone content, said William G. Helferich, a UI professor of food science and human nutrition. Many soy isoflavone-containing products are marketed to women over age 50 for the relief of menopausal symptoms.

“Our pre-clinical laboratory animal data suggest that caution is warranted regarding the use of soy supplements high in isoflavones for women with breast cancer, particularly if they are menopausal,” said Helferich, who was the principal researcher on the papers.

For most people, soy is a healthy food and can be used as part of a healthy diet, he said. Isolated soy protein had been found in previous UI studies to effectively lower cholesterol. Studies elsewhere have shown potential relief of menopausal symptoms and protection against cancer.

In the Journal of Nutrition, Helferich and colleagues show that the estrogen-dependent tumors implanted into experimental mice models grow at a rate in proportion to the levels of genistein consumed. Researchers used athymic mice that lack the ability to reject human cancer cells. After inserting breast cancer cells, researchers were able to closely monitor the dietary estrogen to stimulate tumor growth.

Genistein at or above 250 parts per million, a dosage that produces blood levels similar to what is observed in women consuming soy diets, was enough to stimulate tumor growth.

In the paper in Carcinogenesis, the researchers compared the isoflavone in its two forms, as a glycoside (genistin, as it appears in plants) and aglucone (genistein). They found that both forms produced similar tumor growth rates, and that the conversion of genistin to genistein in the body begins with contact with saliva in the mouth.

In Cancer Research, Helferich compared soy protein isolates containing varying levels of isoflavones. The researchers found that estrogen-dependent tumor growth increased as the isoflavone content increased in the soy-containing diet.


Story Source:

The above story is based on materials provided by University Of Illinois At Urbana-Champaign. Note: Materials may be edited for content and length.


Cite This Page:

University Of Illinois At Urbana-Champaign. "Estrogen Found In Soy Stimulates Human Breast-Cancer Cells In Mice." ScienceDaily. ScienceDaily, 5 November 2001. <www.sciencedaily.com/releases/2001/11/011105073548.htm>.
University Of Illinois At Urbana-Champaign. (2001, November 5). Estrogen Found In Soy Stimulates Human Breast-Cancer Cells In Mice. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2001/11/011105073548.htm
University Of Illinois At Urbana-Champaign. "Estrogen Found In Soy Stimulates Human Breast-Cancer Cells In Mice." ScienceDaily. www.sciencedaily.com/releases/2001/11/011105073548.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins