Featured Research

from universities, journals, and other organizations

Molecular "Nanogenerator" Developed That Can Target Cancer Cells And Destroy Them

Date:
November 16, 2001
Source:
Memorial Sloan-Kettering Cancer Center
Summary:
Researchers at Memorial Sloan-Kettering Cancer Center (MSKCC) have developed a molecular nanogenerator that releases a cascade of atomic fragments known as alpha particles on the inside of cancer cells. These nanogenerators consist of a single radioactive atom contained inside a molecular cage and attached to an antibody that homes in on cancer cells -- carrying the generator to the interior of those cells and destroying them. The results of this work are published in the November 16 issue of Science.

NEW YORK, November 15, 2001 – Researchers at Memorial Sloan-Kettering Cancer Center (MSKCC) have developed a molecular nanogenerator that releases a cascade of atomic fragments known as alpha particles on the inside of cancer cells. These nanogenerators consist of a single radioactive atom contained inside a molecular cage and attached to an antibody that homes in on cancer cells -- carrying the generator to the interior of those cells and destroying them. The results of this work are published in the November 16 issue of Science.

“We have found an effective way of containing and then delivering this highly potent element directly into cancer cells,” said study senior author David A. Scheinberg, M.D., Ph.D., Chief of MSKCC’s Leukemia Service and head of the Laboratory of Hematopoietic Cancer Immunochemistry at the Sloan-Kettering Institute.

The investigators tested the nanogenerators in cell culture in a variety of human cancer cell types: leukemia, lymphoma, breast, ovarian, neuroblastoma, and prostate. They found the nanogenerators could kill all these types of cancer cells at extremely low concentrations.

Dr. Scheinberg and colleagues also tested the treatment in two mouse models, one for prostate cancer and one for disseminated (widespread) lymphoma. Many of the animals had long-term survival, and all of them had their lives extended after a single treatment at a low dose. In addition, many of the mice with prostate cancer had their prostate-specific antigen (PSA) levels decrease to zero and most others had PSA levels that were reduced. PSA levels are a common measure of the presence of prostate cancer in humans.

The atom contained inside the nanogenerator is actinium-225. Actinium decays by giving off short-lived, high-energy alpha particles that blast through cancer cells and destroy their DNA and proteins. When actinium decays, it produces a series of three daughter atoms each of which gives off its own alpha particle. Each particle increases the chance that the cancer cell will be destroyed. “You get four times the punch from one atom,” Dr. Scheinberg said.

Targeting the generator to the inside of the cancer cells also increases the treatment’s effectiveness. “If the atom is sitting on the outside of the cell, the alpha particle can travel in any direction, and it kills the cell only a fraction of the time,” explained Michael McDevitt, Ph.D., the study’s lead author and a senior research scientist in Dr. Scheinberg’s lab. “If the generator is inside the cell, every particle will be effective.” In addition, keeping the generator inside the cell greatly reduces the possibility that the daughter atoms could float off and damage healthy cells.

Numerous developments in technology have made the new nanogenerators possible. “The idea of targeting radioactive metals to tumors was first demonstrated by us in 1981,” Dr. Scheinberg said. “So it’s taken us 20 years to get to this more effective and sophisticated method.” A large part of this advance was the development of antibodies that target various types of tumor cells in humans. In addition, researchers were able to identify an appropriate atom, actinium (which has long enough half-life to allow doctors time to administer the drug after it has been manufactured) and secure a supply of it from the Department of Energy -- because it is a by-product of waste from nuclear power plants and weapons. Finally, the researchers found a molecular cage, such as one developed by the Dow Chemical Company, that would hold the actinium atom.

Dr. Scheinberg and his team plan to file an application with the Food and Drug Administration to begin trials in humans sometime next year. He says leukemia will most likely be the first cancer the nanogenerators are tested on, because his team has the most experience targeting those types of tumors. Although the mice treated with the drug seemed to experience no toxic side effects, the true test of whether this will become an effective therapy will not be known until those human trials begin, Dr. Scheinberg noted.

This research was supported by the Doris Duke Charitable Foundation, the National Institutes of Health, the CaPCure Foundation, the Lymphoma Foundation, the Cure for Lymphoma Foundation, the Gabrielle Rich Foundation, and the Pepsico Foundation.

Memorial Sloan-Kettering Cancer Center is the world's oldest and largest private institution devoted to prevention, patient care, research, and education in cancer. Our scientists and clinicians generate innovative approaches to better understand, diagnose and treat cancer. Our specialists are leaders in biomedical research and in translating the latest research to advance the standard of cancer care worldwide.


Story Source:

The above story is based on materials provided by Memorial Sloan-Kettering Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

Memorial Sloan-Kettering Cancer Center. "Molecular "Nanogenerator" Developed That Can Target Cancer Cells And Destroy Them." ScienceDaily. ScienceDaily, 16 November 2001. <www.sciencedaily.com/releases/2001/11/011116065322.htm>.
Memorial Sloan-Kettering Cancer Center. (2001, November 16). Molecular "Nanogenerator" Developed That Can Target Cancer Cells And Destroy Them. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2001/11/011116065322.htm
Memorial Sloan-Kettering Cancer Center. "Molecular "Nanogenerator" Developed That Can Target Cancer Cells And Destroy Them." ScienceDaily. www.sciencedaily.com/releases/2001/11/011116065322.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins