Featured Research

from universities, journals, and other organizations

Mother's Herpes Virus Infection Associated With Schizophrenia In Her Offspring, Hopkins Researcher Finds

Date:
November 22, 2001
Source:
Johns Hopkins Medical Institutions
Summary:
Scientists at Johns Hopkins Children's Center and six other research centers have found that mothers who have had a herpes simplex virus type 2 (HSV-2) infection at the time of birth are more likely to give birth to children who develop schizophrenia or other psychotic disorders. HSV-2 is a sexually transmitted disease that differs from its common, cold sore-causing cousin, HSV-1.

Scientists at Johns Hopkins Children's Center and six other research centers have found that mothers who have had a herpes simplex virus type 2 (HSV-2) infection at the time of birth are more likely to give birth to children who develop schizophrenia or other psychotic disorders. HSV-2 is a sexually transmitted disease that differs from its common, cold sore-causing cousin, HSV-1.

Related Articles


Based on stored blood samples and medical records dating as far back as the late 1950s, the correlative study in this month's Archives of General Psychiatry is the first to compare direct laboratory evidence of specific maternal infections with the development of psychosis in children.

"The evidence shows some association of maternal herpes simplex 2 virus with schizophrenia later in life," says Children's Center neurovirologist Robert Yolken, M.D., a coauthor of the study. "However, whether the herpes infection is a direct cause or just a factor is still unknown."

Researchers drew their subjects from the Providence, Rhode Island group of the Collaborative Perinatal Project (CPP), a large-scale, nationwide study that monitored 55,000 pregnancies at 12 study sites in the United States between 1959 and 1966. The CPP also evaluated infants for physical and mental development during the first seven years of life and stored blood samples from mothers for later analysis.

Of the 3,804 surviving offspring of 3,078 pregnant women from the Providence group, 27 children were diagnosed with schizophrenia or another psychotic disorder. Fifty-four other mothers and children without psychotic disorders from the Providence group were studied as a control group. The psychological health of children in the study was assessed by medical record analysis and telephone interviews. None of the offspring in the case group had experienced encephalitis or other major neurological abnormalities at birth.

The researchers determined maternal infection by the presence of elevated levels of antibodies to HSV-2. Antibodies to other infectious agents, including Chlamydia trachomatis (chlamydia), Toxoplasma gondii (toxoplasmosis), rubellavirus (rubella), cytomegalovirus (viral pneumonia), the human papilloma virus (genital warts), and HSV-1 (cold sores) were equally low in the mothers of both psychotic and non-psychotic children. Because antibodies to other sexually transmitted diseases were not different between the groups, Yolken says sexual activity of the mother is not, by itself, a predictive factor for the development of psychosis in their offspring.

Of the two major herpes simplex virus types, HSV-1 is extremely pervasive in the human population and does not require sexual contact to be transmitted. HSV-2 is rarer and more dangerous, and is typically transmitted sexually. The replication of both viruses can be countered by antiviral medications.

Stephen Buka, Sc.D., and Ming Tsuang, M.D., Ph.D., of Harvard's School of Public Health and School of Medicine and the Harvard Institute of Psychiatric Epidemiology and Genetics; E. Fuller Torrey, M.D., of the Stanley Research Laboratory; Mark Klebanoff, M.D., of the National Institute of Child Health and Human Development; and David Bernstein, M.D., of the Children's Hospital Medical Center in Cincinnati also contributed to the study. The Stanley Foundation funded the study with additional support from the National Institute of Mental Health.


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "Mother's Herpes Virus Infection Associated With Schizophrenia In Her Offspring, Hopkins Researcher Finds." ScienceDaily. ScienceDaily, 22 November 2001. <www.sciencedaily.com/releases/2001/11/011120060152.htm>.
Johns Hopkins Medical Institutions. (2001, November 22). Mother's Herpes Virus Infection Associated With Schizophrenia In Her Offspring, Hopkins Researcher Finds. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2001/11/011120060152.htm
Johns Hopkins Medical Institutions. "Mother's Herpes Virus Infection Associated With Schizophrenia In Her Offspring, Hopkins Researcher Finds." ScienceDaily. www.sciencedaily.com/releases/2001/11/011120060152.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins