Depression And Anxiety Increase Risk Of Fatal Stroke

But psychological distress did not significantly increase the risk for non-fatal stroke and there was no link between mood disorders and increased risk for transient ischemic attacks, or TIAs – the so-called mini-strokes that are sometimes precursors to major strokes.

The findings are from the latest report of an on-going study of middle-aged men who live in an area of South Wales, says Margaret May, MSc, lead author of the study.

“The study is one of the largest and best-designed studies that link depression to mortality,” says Robert M. Carney, Ph.D., professor of medical psychology at the Washington University School of Medicine in St. Louis. Carney co-authored an editorial that accompanies the Caerphilly Study results.

The Caerphilly Study included men who were registered to vote in Caerphilly. The men were asked to volunteer for the study of cardiovascular disease and related outcomes. The latest report is based on phase II of the study and includes 2,124 men aged 49 to 64 who were recruited between 1979 and 1988.

In a 30-item General Health Questionnaire, used to measure psychological distress, 22 percent of the men had test scores that indicated mood disorders. Detailed medical histories, smoking history, as well as height, weight, and blood pressure data were also collected. Each man underwent heart testing with an electrocardiogram. The men were then followed for 14 years, during which time the researchers collected data on the incidence of stroke.

During follow-up, 137 strokes occurred, including 17 fatal strokes. In general, men who had strokes were older, heavier and had higher blood pressure levels than men who didn’t have strokes. The men who had strokes were also more likely to be current smokers and to have at least one other chronic disease.

When May and her colleagues analyzed psychological profile data, they found that “the men who had strokes also showed a tendency to report more symptoms of anxiety and depression.” Moreover, a history of psychological distress was associated with a 3.36 relative risk for fatal stroke and a 1.25 relative risk for non-fatal stroke. The relative risk for TIA was 0.63. When the findings were adjusted for other risk factors, such as smoking and high blood pressure, the relative risk for fatal stroke declined to 2.56.