Featured Research

from universities, journals, and other organizations

Blood Markers May Reflect Newborns' Potential Of Contracting HIV

Date:
January 21, 2002
Source:
Johns Hopkins Medical Institutions
Summary:
Preventing HIV-infected pregnant women from transmitting the virus to their newborns has long been a major concern for obstetricians. As such, many doctors continue to debate the benefits of elective Caesarian section as a way to protect the infant.

Preventing HIV-infected pregnant women from transmitting the virus to their newborns has long been a major concern for obstetricians. As such, many doctors continue to debate the benefits of elective Caesarian section as a way to protect the infant.

Related Articles


In high-risk pregnancies, where the viral loads can't be suppressed with medication, delivering a baby by C-section directly from the protected, sterile environment of the amniotic sac can limit the risk of HIV transmission. But in lower-risk pregnancies, where antiretroviral medications keep the virus in check, the risk of transmitting HIV to a newborn is only about 1 percent to 2 percent.

A new study by researchers at Johns Hopkins and the National Institutes of Health demonstrates that uncomplicated labor and vaginal delivery does not stimulate the babies' immune systems. Results are scheduled to be presented Jan. 18 at the annual meeting of the Society for Maternal-Fetal Medicine in New Orleans.

A research team led by Hopkins obstetrician Helene Bernstein, M.D., Ph.D., studied lymphocytes from the umbilical cords of 23 babies born by vaginal delivery or elective C-section, as well as cells taken from eight babies born to mothers who had chorioamnionitis (a bacterial infection of the amniotic sac) or preterm labor.

None of the women had HIV. Checking for specific biochemical markers of white blood cell activation, they found the level of cell activity to be similar among babies born by either method. In addition, when HIV was introduced to these cells in the laboratory, there was no difference in their ability to be infected.

However, the babies born to mothers with chorioamnionitis or preterm labor did show activation of their white blood cells. When HIV was introduced to the white blood cells in the laboratory, there were more infections and the virus grew quickly, meaning that these infants could be at higher risk for HIV transmission if born to HIV-infected mothers with these prenatal conditions. In addition, these babies had higher levels of CCR5, a molecule that HIV uses to infect cells.

"These results help us understand why children born to HIV-infected mothers with chorioamnionitis or preterm labor have a higher risk of transmission," says Bernstein, an instructor of gynecology and obstetrics.

"Physicians may want to consider these findings when caring for infants at risk for HIV transmission after these problems. Other potential implications for clinical practice may include more aggressive treatment of HIV-infected mothers with these prenatal conditions."

Other study authors include Audrey Kinter, Tae-Wook Chun, Robert Jackson and Claire Hallahan, all of the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "Blood Markers May Reflect Newborns' Potential Of Contracting HIV." ScienceDaily. ScienceDaily, 21 January 2002. <www.sciencedaily.com/releases/2002/01/020121091108.htm>.
Johns Hopkins Medical Institutions. (2002, January 21). Blood Markers May Reflect Newborns' Potential Of Contracting HIV. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2002/01/020121091108.htm
Johns Hopkins Medical Institutions. "Blood Markers May Reflect Newborns' Potential Of Contracting HIV." ScienceDaily. www.sciencedaily.com/releases/2002/01/020121091108.htm (accessed October 24, 2014).

Share This



More Mind & Brain News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Academic Scandal Shocks UNC

Academic Scandal Shocks UNC

AP (Oct. 23, 2014) A scandal involving bogus classes and inflated grades at the University of North Carolina was bigger than previously reported, a new investigation found. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Working Mother Getaway: Beaches Turks & Caicos

Working Mother Getaway: Beaches Turks & Caicos

Working Mother (Oct. 22, 2014) Feast your eyes on this gorgeous family-friendly resort. Video provided by Working Mother
Powered by NewsLook.com
What Your Favorite Color Says About You

What Your Favorite Color Says About You

Buzz60 (Oct. 22, 2014) We all have one color we love to wear, and believe it or not, your color preference may reveal some of your character traits. In celebration of National Color Day, Krystin Goodwin (@kyrstingoodwin) highlights what your favorite colors may say about you. Video provided by Buzz60
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins