Featured Research

from universities, journals, and other organizations

Therapy Found To Relieve Fatigue Of Multiple Sclerosis Patients

Date:
January 21, 2002
Source:
Ohio State University
Summary:
For the first time, researchers here have found an effective therapy that can alleviate the fatigue often accompanying multiple sclerosis. Many therapies have been developed to treat symptoms of multiple sclerosis, but few have helped, to any degree, the excessive, debilitating fatigue that accompanies other disease symptoms in some patients.

COLUMBUS, Ohio - For the first time, researchers here have found an effective therapy that can alleviate the fatigue often accompanying multiple sclerosis. Many therapies have been developed to treat symptoms of multiple sclerosis, but few have helped, to any degree, the excessive, debilitating fatigue that accompanies other disease symptoms in some patients.

Their study appears today in the Journal of Neurology, Neurosurgery and Psychiatry.

Dr. Kottil W. Rammohan, neurologist at The Ohio State University Medical Center, and his colleagues wondered whether the drug modafinil might be effective in relieving this fatigue. Modafinil is used currently in the treatment of narcolepsy, a disease in which patients experience uncontrolled daytime sleepiness.

"We were very pleased to find that a medication that was effective against narcolepsy was able to treat the fatigue associated with multiple sclerosis."

Two doses of modafinil (200 and 400 mg) were compared against a placebo in 72 patients with multiple sclerosis ranging in age from 18 to 65. It was observed that the 200 mg dose of the drug administered once daily showed highly significant improvement in patients. Three separate instruments of rating fatigue were used, and all three showed concordant response to this drug. No previous drug has been able to show this degree of improvement in treating multiple sclerosis-related fatigue in any previous clinical trial.

"We were very pleased to find that a medication that was effective against narcolepsy was able to treat the fatigue associated with multiple sclerosis," said Rammohan, lead author of the study.

Rammohan's group also looked at the potential side effects associated with this medication and found that they were not greater than those experienced by patients in the study who received a placebo.

"It is always exciting to find an effective therapy that is void of serious side effects," said Rammohan.

Fatigue is one of the most common and disabling symptoms of multiple sclerosis. It affects 75 to 90 percent of patients with the disease. As many as 46 to 66 percent of multiple sclerosis patients experience fatigue on a daily basis.

Rammohan said that more studies are needed to better understand the dosage and length of therapy necessary for patients, but he hopes more neurologists will start using modafinil for the treatment of severe fatigue that often accompanies multiple sclerosis.

Also participating in this study were researchers at Kaiser Permanente in San Diego.

Multiple sclerosis is an unpredictable, progressive disease in which scattered patches of nerve fibers in the brain and spinal cord lose "myelin," their protective covering. Resultant loss of neurological function can manifest with a multitude of symptoms.

In addition to fatigue, patients experience a combination of a number of symptoms that include visual loss, loss of motor function, sensory impairment, imbalance, bowel and bladder dysfunction, and sometimes problems related to cognition, memory and personality. Multiple sclerosis is a common disorder and affects about 350,000 people in the United States, mostly women.


Story Source:

The above story is based on materials provided by Ohio State University. Note: Materials may be edited for content and length.


Cite This Page:

Ohio State University. "Therapy Found To Relieve Fatigue Of Multiple Sclerosis Patients." ScienceDaily. ScienceDaily, 21 January 2002. <www.sciencedaily.com/releases/2002/01/020121091319.htm>.
Ohio State University. (2002, January 21). Therapy Found To Relieve Fatigue Of Multiple Sclerosis Patients. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2002/01/020121091319.htm
Ohio State University. "Therapy Found To Relieve Fatigue Of Multiple Sclerosis Patients." ScienceDaily. www.sciencedaily.com/releases/2002/01/020121091319.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins