Featured Research

from universities, journals, and other organizations

Adult Bone Marrow Stem Cells Can Become Blood Vessels

Date:
January 31, 2002
Source:
University Of Minnesota
Summary:
Researchers at the University of Minnesota Stem Cell Institute (SCI) have demonstrated, for the first time, the ability of adult bone marrow stem cells to expand in vitro as endothelial cells (which line blood- and lymphatic vessels) and then engraft in vivo and contribute to new growth of blood vessels (neoangiogenesis).

MINNEAPOLIS / ST. PAUL -- Researchers at the University of Minnesota Stem Cell Institute (SCI) have demonstrated, for the first time, the ability of adult bone marrow stem cells to expand in vitro as endothelial cells (which line blood- and lymphatic vessels) and then engraft in vivo and contribute to new growth of blood vessels (neoangiogenesis). The findings will be published in the February 1, 2002 issue of the Journal of Clinical Investigation.

"These lab results demonstrate the potential of adult bone marrow stem cells to differentiate beyond mesenchymal cells, into cells of the endothelium," said Catherine Verfaillie, M.D., director of the University of Minnesota Stem Cell Institute and author of the research. "What we have seen is the ability of these cells to feed the blood vessels of tumors and to heal the blood vessels surrounding wounds. The findings suggest that these adult stem cells may be an ideal source of cells for clinical therapy. For example, we can envision the use of these stem cells for therapies against cancer tumors by, for instance, introducing anti-angiogenesis genes. Or, they could be used to heal wounds such as ulcers or diabetic wounds or to treat atherosclerosis."

Verfaillie and her colleagues announced late last year that these cells, called multipotent adult progenitor cells (MAPCs), demonstrate the potential to differentiate beyond mesenchymal cells, into cells of the visceral mesodermal origin, such as endothelium, and may be capable of differentiating into nonmesodermal cell types, such as neurons, astrocytes, oligodendrocytes, and liver.

The paper can be found at http://www.jci.org.

The objective of the Stem Cell Institute is to further our understanding of the potential of stem cells to improve human and animal health. The SCI is a part of the University of Minnesota's Academic Health Center and is an interdisciplinary center with member faculty representing a diverse group of university schools, colleges and centers. For online information about the University of Minnesota's Stem Cell Institute, go to http://www1.umn.edu/stemcell.


Story Source:

The above story is based on materials provided by University Of Minnesota. Note: Materials may be edited for content and length.


Cite This Page:

University Of Minnesota. "Adult Bone Marrow Stem Cells Can Become Blood Vessels." ScienceDaily. ScienceDaily, 31 January 2002. <www.sciencedaily.com/releases/2002/01/020131074645.htm>.
University Of Minnesota. (2002, January 31). Adult Bone Marrow Stem Cells Can Become Blood Vessels. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2002/01/020131074645.htm
University Of Minnesota. "Adult Bone Marrow Stem Cells Can Become Blood Vessels." ScienceDaily. www.sciencedaily.com/releases/2002/01/020131074645.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins