Featured Research

from universities, journals, and other organizations

Hebrew University Research Finds Why Chemotherapy Might Lead To Cancer

Date:
February 27, 2002
Source:
Hebrew University Of Jerusalem
Summary:
A study of chromosomes in cancerous cells conducted at the Hebrew University of Jerusalem found that some chemotherapy drugs actually create the conditions that generate new cancerous growths. Associate Professor of Genetics Batsheva Kerem’s article on this study will be featured in the inaugural edition of Cancer Cell, which will be published on February 26, 2002.

Jerusalem, February 25, 2002 – A study of chromosomes in cancerous cells conducted at the Hebrew University of Jerusalem found that some chemotherapy drugs actually create the conditions that generate new cancerous growths. Associate Professor of Genetics Batsheva Kerem’s article on this study will be featured in the inaugural edition of Cancer Cell, which will be published on February 26, 2002. Prof. Kerem, who is renowned for her work on the genetics of cystic fibrosis, said that her research can lead to the development of more effective and less damaging chemotherapy drugs.

Prof. Kerem and PhD candidate Asaf Hellman explain that in studying the differences between cancerous and healthy cells they found that the chromosomes of cancerous cells break recurrently at specific regions known as "fragile sites."

In a previous study, Prof. Kerem and Asaf Hellman showed that fragile sites are sites where the mechanism responsible for DNA replication is disturbed. This could lead to breakage resulting in multiple rearrangements of the chromosomes, a striking characteristic of cancer cells.

Prof. Kerem explained that there are some 100 fragile sites in the human genome and five of these sites are now being studied.

Prof. Kerem explained that normal cells develop fragile regions when they are exposed to certain conditions. Some of the drugs used in chemotherapy may cause these conditions and thus plant the seeds of a future cancerous growth while they are killing the current one.

Our work creates a better understanding of how drugs used against cancer work, which will lead to the creation of the next generation of drugs, which can halt the growth of cancerous cells without inducing fragile sites, Asaf Hellman said.

Cancer Cell is a new publication of Cell Press, which publishes the journals Cell, Molecular Cell, Developmental Cell, Neuron, and Immunity.


Story Source:

The above story is based on materials provided by Hebrew University Of Jerusalem. Note: Materials may be edited for content and length.


Cite This Page:

Hebrew University Of Jerusalem. "Hebrew University Research Finds Why Chemotherapy Might Lead To Cancer." ScienceDaily. ScienceDaily, 27 February 2002. <www.sciencedaily.com/releases/2002/02/020226074931.htm>.
Hebrew University Of Jerusalem. (2002, February 27). Hebrew University Research Finds Why Chemotherapy Might Lead To Cancer. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2002/02/020226074931.htm
Hebrew University Of Jerusalem. "Hebrew University Research Finds Why Chemotherapy Might Lead To Cancer." ScienceDaily. www.sciencedaily.com/releases/2002/02/020226074931.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins