Featured Research

from universities, journals, and other organizations

Hebrew University Research Finds Why Chemotherapy Might Lead To Cancer

Date:
February 27, 2002
Source:
Hebrew University Of Jerusalem
Summary:
A study of chromosomes in cancerous cells conducted at the Hebrew University of Jerusalem found that some chemotherapy drugs actually create the conditions that generate new cancerous growths. Associate Professor of Genetics Batsheva Kerem’s article on this study will be featured in the inaugural edition of Cancer Cell, which will be published on February 26, 2002.

Jerusalem, February 25, 2002 – A study of chromosomes in cancerous cells conducted at the Hebrew University of Jerusalem found that some chemotherapy drugs actually create the conditions that generate new cancerous growths. Associate Professor of Genetics Batsheva Kerem’s article on this study will be featured in the inaugural edition of Cancer Cell, which will be published on February 26, 2002. Prof. Kerem, who is renowned for her work on the genetics of cystic fibrosis, said that her research can lead to the development of more effective and less damaging chemotherapy drugs.

Prof. Kerem and PhD candidate Asaf Hellman explain that in studying the differences between cancerous and healthy cells they found that the chromosomes of cancerous cells break recurrently at specific regions known as "fragile sites."

In a previous study, Prof. Kerem and Asaf Hellman showed that fragile sites are sites where the mechanism responsible for DNA replication is disturbed. This could lead to breakage resulting in multiple rearrangements of the chromosomes, a striking characteristic of cancer cells.

Prof. Kerem explained that there are some 100 fragile sites in the human genome and five of these sites are now being studied.

Prof. Kerem explained that normal cells develop fragile regions when they are exposed to certain conditions. Some of the drugs used in chemotherapy may cause these conditions and thus plant the seeds of a future cancerous growth while they are killing the current one.

Our work creates a better understanding of how drugs used against cancer work, which will lead to the creation of the next generation of drugs, which can halt the growth of cancerous cells without inducing fragile sites, Asaf Hellman said.

Cancer Cell is a new publication of Cell Press, which publishes the journals Cell, Molecular Cell, Developmental Cell, Neuron, and Immunity.


Story Source:

The above story is based on materials provided by Hebrew University Of Jerusalem. Note: Materials may be edited for content and length.


Cite This Page:

Hebrew University Of Jerusalem. "Hebrew University Research Finds Why Chemotherapy Might Lead To Cancer." ScienceDaily. ScienceDaily, 27 February 2002. <www.sciencedaily.com/releases/2002/02/020226074931.htm>.
Hebrew University Of Jerusalem. (2002, February 27). Hebrew University Research Finds Why Chemotherapy Might Lead To Cancer. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2002/02/020226074931.htm
Hebrew University Of Jerusalem. "Hebrew University Research Finds Why Chemotherapy Might Lead To Cancer." ScienceDaily. www.sciencedaily.com/releases/2002/02/020226074931.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins