Featured Research

from universities, journals, and other organizations

Transplanted Stem Cells Restore Function In Stroke

Date:
March 5, 2002
Source:
University Of Minnesota
Summary:
Researchers at the University of Minnesota department of neurosurgery and Stem Cell Institute (SCI) have demonstrated the ability of transplanted adult stem cells to restore function in laboratory animals with stroke. Stem cells were isolated and expanded from human bone marrow and transplanted into laboratory rats seven days after an ischemic stroke injury to the brain. Before transplantation, rats were unable to properly use forelimbs and hind limbs. Weeks after receiving stem cell transplants, the animals regained proper use of their limbs.

MINNEAPOLIS / ST. PAUL -- Researchers at the University of Minnesota department of neurosurgery and Stem Cell Institute (SCI) have demonstrated the ability of transplanted adult stem cells to restore function in laboratory animals with stroke. Stem cells were isolated and expanded from human bone marrow and transplanted into laboratory rats seven days after an ischemic stroke injury to the brain. Before transplantation, rats were unable to properly use forelimbs and hind limbs. Weeks after receiving stem cell transplants, the animals regained proper use of their limbs. The study is reported in the March 2002 issue of Experimental Neurology.

Walter Low, Ph.D., a professor of neurosurgery, was the principal investigator for the study. Other investigators were Li-Ru Zhao, M.D., a research associate in the department of neurosurgery, Catherine Verfaillie, M.D., director of the Stem Cell Institute, and Morayma Reyes, a medical and doctoral student in the Medical School.

Previous studies from these investigators demonstrated that adult stem cells isolated from human bone marrow could be induced to differentiate into different types of cells when grown in tissue culture. In the present study, the transplanted stem cells were found to develop into cells that exhibited the characteristics of neurons, astrocytes, and oligodendroglia, the major types of cells found within the brain. These findings suggest that stem cells obtained from adult bone marrow may be useful as a source of cells to repair the brain and restore function in patients who have suffered a stroke.

"The ability of bone marrow stem cells to differentiate into cells that are typically found in the brain and restore function in laboratory animals with stroke holds promise for people who have experienced a stroke," said Low. "However, there are many additional studies on these stem cells that need to be conducted before we can consider initiating any clinical trial.

"The next steps in this research will be to determine how long after a stroke stem cell transplant therapy will be effective. Can stem cells be transplanted one, two, six or 12 months after a stroke and still restore function? Another important question that still needs to be addressed for this research is whether bone marrow stem cells maintain a stable neural phenotype over prolonged periods after transplantation."

Verfaillie and her colleagues announced late last year that these cells, called multipotent adult progenitor cells (MAPCs), demonstrate the potential to differentiate beyond mesenchymal cells, into cells of the visceral mesodermal origin, such as endothelium, and may be capable of differentiating into nonmesodermal cell types, such as neurons, astrocytes, oligodendrocytes and liver.

The objective of the Stem Cell Institute is to further our understanding of the potential of stem cells to improve human and animal health. The SCI is a part of the University of Minnesota's Academic Health Center and is an interdisciplinary center with member faculty representing a diverse group of University schools, colleges and centers. For online information about the University of Minnesota's Stem Cell Institute, go to http://www.umn.edu/stemcell.


Story Source:

The above story is based on materials provided by University Of Minnesota. Note: Materials may be edited for content and length.


Cite This Page:

University Of Minnesota. "Transplanted Stem Cells Restore Function In Stroke." ScienceDaily. ScienceDaily, 5 March 2002. <www.sciencedaily.com/releases/2002/03/020305073456.htm>.
University Of Minnesota. (2002, March 5). Transplanted Stem Cells Restore Function In Stroke. ScienceDaily. Retrieved August 23, 2014 from www.sciencedaily.com/releases/2002/03/020305073456.htm
University Of Minnesota. "Transplanted Stem Cells Restore Function In Stroke." ScienceDaily. www.sciencedaily.com/releases/2002/03/020305073456.htm (accessed August 23, 2014).

Share This




More Health & Medicine News

Saturday, August 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins