Featured Research

from universities, journals, and other organizations

In Heart Failure, Beta-Blockers Boost Survival Advantage For Women

Date:
March 18, 2002
Source:
American Heart Association
Summary:
Beta-blockers benefit women as much as men, according to one of the largest studies to examine gender differences in treating heart failure, researchers report in Circulation: Journal of the American Heart Association.

DALLAS, March 12 – Beta-blockers benefit women as much as men, according to one of the largest studies to examine gender differences in treating heart failure, researchers report in today’s rapid access issue of Circulation: Journal of the American Heart Association.

Related Articles


“Women with heart failure should be battling the disease with the same weapons as men,” says Jalal K. Ghali, M.D., director of clinical research at Cardiac Centers of Louisiana in Shreveport, who led the study that looked at the effect of beta-blockers on the combined endpoints of mortality and hospitalization. Women who took the beta-blocker metoprolol CR/XL lived longer and were hospitalized less often than women who were not on the drugs.

Pooled data from the three largest heart failure studies of beta-blockers found increased survival in women taking beta-blockers. “The individual studies may not have had enough subjects to detect a survival benefit, but the combined data show a benefit from these drugs. Based on our results, clinicians should feel very comfortable prescribing beta-blockers to women, and not think twice about gender-related differences in their effects,” Ghali says.

Researchers analyzed the effect of metoprolol CR/XL in women in the Metoprolol CR/XL Randomized Intervention Trial in Heart Failure (MERIT-HF), the largest database of women taking beta-blockers to treat heart failure.

They analyzed the effect of the drug on a subgroup of women with severe heart failure. The researchers also pooled data from two other large studies to analyze overall survival benefits of the three beta-blockers for women: the Cardiac Insufficiency Bisoprolol Study (CIBIS-II), looking at the beta-blocker bisoprolol, and the Carvedilol Prospective Randomized Cumulative Survival Study Group (COPERNICUS), which studied carvedilol. MERIT-HF had a total of 3,991 patients with heart failure and LVEF of less than 40 percent. The trial showed a 34 percent reduction in deaths.

Ghali’s team looked more closely at the 898 women in MERIT-HF, focusing on total death and hospitalization and found a 21 percent overall reduction in death and hospitalization per patient per year in the metoprolol CR/XL group compared to the placebo group. There was a 19 percent reduction in all-cause hospitalization in women, a 29 percent drop in cardiovascular-related hospitalization and 42 percent fewer hospitalizations for heart failure.

Combined data with the CIBIS II and COPERNICUS studies showed that in women, the three beta-blockers – metoprolol CR/XL, bisoprolol and carvedilol – increased total survival similar to that of men.

Co-authors are Ileana L. Piña, M.D.; Stephen S. Gottlieb, M.D.; Prakash C. Deedwania, M.D.; and John C. Wikstrand, M.D, Ph.D.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "In Heart Failure, Beta-Blockers Boost Survival Advantage For Women." ScienceDaily. ScienceDaily, 18 March 2002. <www.sciencedaily.com/releases/2002/03/020313075628.htm>.
American Heart Association. (2002, March 18). In Heart Failure, Beta-Blockers Boost Survival Advantage For Women. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2002/03/020313075628.htm
American Heart Association. "In Heart Failure, Beta-Blockers Boost Survival Advantage For Women." ScienceDaily. www.sciencedaily.com/releases/2002/03/020313075628.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) — It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) — More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) — In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) — A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins