Featured Research

from universities, journals, and other organizations

In Heart Failure, Beta-Blockers Boost Survival Advantage For Women

Date:
March 18, 2002
Source:
American Heart Association
Summary:
Beta-blockers benefit women as much as men, according to one of the largest studies to examine gender differences in treating heart failure, researchers report in Circulation: Journal of the American Heart Association.

DALLAS, March 12 – Beta-blockers benefit women as much as men, according to one of the largest studies to examine gender differences in treating heart failure, researchers report in today’s rapid access issue of Circulation: Journal of the American Heart Association.

“Women with heart failure should be battling the disease with the same weapons as men,” says Jalal K. Ghali, M.D., director of clinical research at Cardiac Centers of Louisiana in Shreveport, who led the study that looked at the effect of beta-blockers on the combined endpoints of mortality and hospitalization. Women who took the beta-blocker metoprolol CR/XL lived longer and were hospitalized less often than women who were not on the drugs.

Pooled data from the three largest heart failure studies of beta-blockers found increased survival in women taking beta-blockers. “The individual studies may not have had enough subjects to detect a survival benefit, but the combined data show a benefit from these drugs. Based on our results, clinicians should feel very comfortable prescribing beta-blockers to women, and not think twice about gender-related differences in their effects,” Ghali says.

Researchers analyzed the effect of metoprolol CR/XL in women in the Metoprolol CR/XL Randomized Intervention Trial in Heart Failure (MERIT-HF), the largest database of women taking beta-blockers to treat heart failure.

They analyzed the effect of the drug on a subgroup of women with severe heart failure. The researchers also pooled data from two other large studies to analyze overall survival benefits of the three beta-blockers for women: the Cardiac Insufficiency Bisoprolol Study (CIBIS-II), looking at the beta-blocker bisoprolol, and the Carvedilol Prospective Randomized Cumulative Survival Study Group (COPERNICUS), which studied carvedilol. MERIT-HF had a total of 3,991 patients with heart failure and LVEF of less than 40 percent. The trial showed a 34 percent reduction in deaths.

Ghali’s team looked more closely at the 898 women in MERIT-HF, focusing on total death and hospitalization and found a 21 percent overall reduction in death and hospitalization per patient per year in the metoprolol CR/XL group compared to the placebo group. There was a 19 percent reduction in all-cause hospitalization in women, a 29 percent drop in cardiovascular-related hospitalization and 42 percent fewer hospitalizations for heart failure.

Combined data with the CIBIS II and COPERNICUS studies showed that in women, the three beta-blockers – metoprolol CR/XL, bisoprolol and carvedilol – increased total survival similar to that of men.

Co-authors are Ileana L. Piña, M.D.; Stephen S. Gottlieb, M.D.; Prakash C. Deedwania, M.D.; and John C. Wikstrand, M.D, Ph.D.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "In Heart Failure, Beta-Blockers Boost Survival Advantage For Women." ScienceDaily. ScienceDaily, 18 March 2002. <www.sciencedaily.com/releases/2002/03/020313075628.htm>.
American Heart Association. (2002, March 18). In Heart Failure, Beta-Blockers Boost Survival Advantage For Women. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2002/03/020313075628.htm
American Heart Association. "In Heart Failure, Beta-Blockers Boost Survival Advantage For Women." ScienceDaily. www.sciencedaily.com/releases/2002/03/020313075628.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) — New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) — Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) — Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) — Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins