
Celecoxib Can Adversely Affect Heart Rhythm, Study Suggests
COX-2 inhibitors like
Celecoxib have come under
scrutiny lately due to
adverse cardiovascular
side-effects stemming from
COX-2 reduction. In both
... > full story

New Understanding of COX-1 and COX-2 Enzymes Could Revise Classification of Pain Meds
COX-1 and COX-2 enzymes may
be blocked by pain
medications such as Advil
and Vioxx in a more complex
manner than was previously
... > full story
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Painkiller Undermines Aspirin's Anti-Clotting Action
December 17, 2009 Millions of Americans take Celebrex for arthritis or other pain. Many, if they are middle-aged or older, also take a low-dose aspirin tablet daily to reduce the risk of heart attack and stroke. Yet ... > full story -
Vioxx Trial Data Shows Early Cardiovascular Risk
November 24, 2009 Evidence of cardiovascular risks associated with taking Vioxx, the popular, nonsteroidal anti-inflammatory drug (rofecoxib), could have been identified nearly four years before its manufacturer, ... > full story -
Potential Lung Disease Biomarkers Yield Clues To COX-2 Inhibitor Side Effects
May 6, 2009 In searching for a simple way to identify individuals with smoking-related lung injury, scientists at have stumbled upon a potential explanation for why the class of pain-relievers known as COX-2 ... > full story -
Popular Arthritis Drug May Disrupt Heart Rhythm, New Research Finds
January 25, 2008 Celebrex, a popular arthritis drug that blocks pain by inhibiting an enzyme known as COX-2, has been shown in laboratory studies to induce arrhythmia, or irregular beating of the heart, via a novel ... > full story -
Vioxx Side-Effects: Possible Explanation
August 29, 2007 Vioxx and related pain medications were taken off the market in 2004 because they caused dangerous heart problems in some people. Scientists may now have figured out how these drugs trigger these ... > full story -
FDA Causes Unnecessary Scare About Common Painkillers, Says Doctor
April 25, 2007 The US Food and Drug Administration has caused an unnecessary scare about some pain relievers by adding a warning to drugs that are safe, says Curt Furberg, M.D., Ph.D., from Wake Forest University ... > full story -
Engineering The 'Super Enzyme' -- A Potential New Weapon Against Heart Disease
November 28, 2006 Efforts to understand the link between the cyclooxygenase-2 (COX-2) inhibitor arthritis drugs and heart disease have had an unanticipated benefit in leading to development of an engineered protein ... > full story -
Celecoxib, Naproxen Safety Results Now Published
November 20, 2006 A paper appearing this week in the Public Library of Science journal PLoS Clinical Trials presents findings from a large National Institutes of Health sponsored trial regarding the cardiovascular and ... > full story -
New Evidence On Risks Associated With Cox-2 Inhibitors And NSAIDs
September 18, 2006 Two new review studies evaluating the safety of the pain-relieving medications selective cyclooxygenase 2 (COX-2) inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs) find increased ... > full story -
New Type Of Pain Reliever May Benefit The Heart
September 13, 2006 Researchers at the University of Pennsylvania School of Medicine have found that deleting an inflammation enzyme in a mouse model of heart disease slowed the development of atherosclerosis. What's ... > full story
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